Malaria drug-sensitivity testing: new assays, new perspectives
Over the past five decades, the drug resistance of Plasmodium falciparum has become an issue of utmost concern. At the same time, in vitro assays for assessing antimalarial drug sensitivity have become indispensable tools for the surveillance of drug resistance and the planning of therapeutic guidel...
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| Veröffentlicht in: | Trends in parasitology 2003-04, Vol.19 (4), p.175-181 |
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| container_title | Trends in parasitology |
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| creator | Noedl, Harald Wongsrichanalai, Chansuda Wernsdorfer, Walther H. |
| description | Over the past five decades, the drug resistance of
Plasmodium falciparum has become an issue of utmost concern. At the same time,
in vitro assays for assessing antimalarial drug sensitivity have become indispensable tools for the surveillance of drug resistance and the planning of therapeutic guidelines. Several new
in vitro assays have been introduced, designed to be easier to handle than previous tests and allow a faster identification of drug-resistant parasites, as well as for simple evaluation of new drugs. This review examines the various new approaches to the
in vitro assessment of malaria drug sensitivity and their limitations. |
| doi_str_mv | 10.1016/S1471-4922(03)00028-X |
| format | Article |
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in vitro assays for assessing antimalarial drug sensitivity have become indispensable tools for the surveillance of drug resistance and the planning of therapeutic guidelines. Several new
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| fulltext | fulltext |
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| ispartof | Trends in parasitology, 2003-04, Vol.19 (4), p.175-181 |
| issn | 1471-4922 1471-5007 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Biological Assay - classification Biological Assay - methods Cells, Cultured Drug Resistance - genetics Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - metabolism Medical sciences Parasitic Sensitivity Tests - methods Pharmacology. Drug treatments Plasmodium falciparum - drug effects Polymerase Chain Reaction - methods |
| title | Malaria drug-sensitivity testing: new assays, new perspectives |
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