Distinct pathways for β-adrenoceptor-induced up-regulation of muscarinic acetylcholine receptors and inhibitory G-protein α-subunits in chicken cardiomyocytes

Exposure of cardiomyocytes from chicken embryos for 3 days to the beta-adrenoceptor agonist, isoproterenol, lead to a down-regulation of beta-adrenoceptors by about 70% and to a decrease in isoproterenol-stimulated adenylyl cyclase activity by about 40% (homologous desensitization). In addition, the...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1992-05, Vol.345 (5), p.530-540
Hauptverfasser:	REITHMANN, C, PANZNER, B, WERDAN, K
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Adenylyl Cyclases - metabolism Adrenergic beta-Agonists - pharmacology Animals beta -adrenergic Biological and medical sciences cardiac muscle Cells, Cultured Chick Embryo chickens Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - metabolism guanine nucleotide-binding proteins Heart induction muscarinic Myocardium - cytology Myocardium - metabolism myocytes pathways receptors Receptors, Muscarinic - drug effects Up-Regulation Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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