Expression of ERalpha and ERbeta in prostate cancer
It has been suggested that estrogens and their receptors (ERs) may be involved in the development and progression of prostate cancer. To elucidate the significance of these receptors, expression of both ERalpha and ERbeta was measured in benign and malignant prostate tumors, as well as in cell lines...
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| Veröffentlicht in: | The Prostate 2003-05, Vol.55 (3), p.180-186 |
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| container_title | The Prostate |
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| creator | Linja, Marika J Savinainen, Kimmo J Tammela, Teuvo L J Isola, Jorma J Visakorpi, Tapio |
| description | It has been suggested that estrogens and their receptors (ERs) may be involved in the development and progression of prostate cancer. To elucidate the significance of these receptors, expression of both ERalpha and ERbeta was measured in benign and malignant prostate tumors, as well as in cell lines.
Expression of ERalpha and ERbeta was measured in prostate hyperplasia (BPH, n = 7), androgen-dependent (n = 30) as well as hormone-refractory (n = 12) prostate carcinomas, and in four prostate cancer cell lines (LNCaP, DU145, PC-3, and 22Rv1) using real-time quantitative RT-PCR.
Only low-level expression of ERalpha was found in all tumor types and cell lines. The level of expression was similar to that observed in breast carcinomas found to be negative for ERalpha by immunohistochemistry. All cell lines showed low, but detectable, levels of ERbeta expression. The mean expression of ERbeta in the hormone-refractory carcinomas was about half that seen in BPH or the androgen-dependent carcinomas; however, the difference was not statistically significant.
The data suggest it is unlikely that alterations in the expression of either ER are commonly involved in the progression of prostate cancer. |
| format | Article |
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Expression of ERalpha and ERbeta was measured in prostate hyperplasia (BPH, n = 7), androgen-dependent (n = 30) as well as hormone-refractory (n = 12) prostate carcinomas, and in four prostate cancer cell lines (LNCaP, DU145, PC-3, and 22Rv1) using real-time quantitative RT-PCR.
Only low-level expression of ERalpha was found in all tumor types and cell lines. The level of expression was similar to that observed in breast carcinomas found to be negative for ERalpha by immunohistochemistry. All cell lines showed low, but detectable, levels of ERbeta expression. The mean expression of ERbeta in the hormone-refractory carcinomas was about half that seen in BPH or the androgen-dependent carcinomas; however, the difference was not statistically significant.
The data suggest it is unlikely that alterations in the expression of either ER are commonly involved in the progression of prostate cancer.</description><identifier>ISSN: 0270-4137</identifier><identifier>PMID: 12692783</identifier><language>eng</language><publisher>United States</publisher><subject>Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma - genetics ; Carcinoma - metabolism ; DNA, Neoplasm - genetics ; DNA, Neoplasm - metabolism ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Prostatic Hyperplasia - genetics ; Prostatic Hyperplasia - metabolism ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Receptors, Estrogen - biosynthesis ; Receptors, Estrogen - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Tumor Cells, Cultured</subject><ispartof>The Prostate, 2003-05, Vol.55 (3), p.180-186</ispartof><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12692783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linja, Marika J</creatorcontrib><creatorcontrib>Savinainen, Kimmo J</creatorcontrib><creatorcontrib>Tammela, Teuvo L J</creatorcontrib><creatorcontrib>Isola, Jorma J</creatorcontrib><creatorcontrib>Visakorpi, Tapio</creatorcontrib><title>Expression of ERalpha and ERbeta in prostate cancer</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>It has been suggested that estrogens and their receptors (ERs) may be involved in the development and progression of prostate cancer. To elucidate the significance of these receptors, expression of both ERalpha and ERbeta was measured in benign and malignant prostate tumors, as well as in cell lines.
Expression of ERalpha and ERbeta was measured in prostate hyperplasia (BPH, n = 7), androgen-dependent (n = 30) as well as hormone-refractory (n = 12) prostate carcinomas, and in four prostate cancer cell lines (LNCaP, DU145, PC-3, and 22Rv1) using real-time quantitative RT-PCR.
Only low-level expression of ERalpha was found in all tumor types and cell lines. The level of expression was similar to that observed in breast carcinomas found to be negative for ERalpha by immunohistochemistry. All cell lines showed low, but detectable, levels of ERbeta expression. The mean expression of ERbeta in the hormone-refractory carcinomas was about half that seen in BPH or the androgen-dependent carcinomas; however, the difference was not statistically significant.
The data suggest it is unlikely that alterations in the expression of either ER are commonly involved in the progression of prostate cancer.</description><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Estrogen Receptor alpha</subject><subject>Estrogen Receptor beta</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Prostatic Hyperplasia - genetics</subject><subject>Prostatic Hyperplasia - metabolism</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Receptors, Estrogen - biosynthesis</subject><subject>Receptors, Estrogen - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Tumor Cells, Cultured</subject><issn>0270-4137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LxDAURbNQnHH0L0hW7gpJXtIkSxnqBwwIMvvymr5ipU1j04L-e0ccV_cuDudyL9hWKCsKLcFu2HXOH0JIIYS6YhupSq-sgy2D6ivNlHM_RT51vHrDIb0jx9ieekML8j7yNE95wYV4wBhovmGXHQ6Zbs-5Y8fH6rh_Lg6vTy_7h0ORjIYCUJOROjSqM5JCacAo3aHwrVNkSkFONoaCa4KxTgeA0pL3SpfOt0DBw47d_2lP858r5aUe-xxoGDDStObagvRG-V_w7gyuzUhtneZ-xPm7_n8JP7IlS0s</recordid><startdate>20030515</startdate><enddate>20030515</enddate><creator>Linja, Marika J</creator><creator>Savinainen, Kimmo J</creator><creator>Tammela, Teuvo L J</creator><creator>Isola, Jorma J</creator><creator>Visakorpi, Tapio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20030515</creationdate><title>Expression of ERalpha and ERbeta in prostate cancer</title><author>Linja, Marika J ; Savinainen, Kimmo J ; Tammela, Teuvo L J ; Isola, Jorma J ; Visakorpi, Tapio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p543-3a4e514cb2f51ec653524fa09d82e560e81b5ec8bc5784c3367e9924689d3ec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Estrogen Receptor alpha</topic><topic>Estrogen Receptor beta</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Prostatic Hyperplasia - genetics</topic><topic>Prostatic Hyperplasia - metabolism</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Receptors, Estrogen - biosynthesis</topic><topic>Receptors, Estrogen - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linja, Marika J</creatorcontrib><creatorcontrib>Savinainen, Kimmo J</creatorcontrib><creatorcontrib>Tammela, Teuvo L J</creatorcontrib><creatorcontrib>Isola, Jorma J</creatorcontrib><creatorcontrib>Visakorpi, Tapio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linja, Marika J</au><au>Savinainen, Kimmo J</au><au>Tammela, Teuvo L J</au><au>Isola, Jorma J</au><au>Visakorpi, Tapio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of ERalpha and ERbeta in prostate cancer</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2003-05-15</date><risdate>2003</risdate><volume>55</volume><issue>3</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0270-4137</issn><abstract>It has been suggested that estrogens and their receptors (ERs) may be involved in the development and progression of prostate cancer. To elucidate the significance of these receptors, expression of both ERalpha and ERbeta was measured in benign and malignant prostate tumors, as well as in cell lines.
Expression of ERalpha and ERbeta was measured in prostate hyperplasia (BPH, n = 7), androgen-dependent (n = 30) as well as hormone-refractory (n = 12) prostate carcinomas, and in four prostate cancer cell lines (LNCaP, DU145, PC-3, and 22Rv1) using real-time quantitative RT-PCR.
Only low-level expression of ERalpha was found in all tumor types and cell lines. The level of expression was similar to that observed in breast carcinomas found to be negative for ERalpha by immunohistochemistry. All cell lines showed low, but detectable, levels of ERbeta expression. The mean expression of ERbeta in the hormone-refractory carcinomas was about half that seen in BPH or the androgen-dependent carcinomas; however, the difference was not statistically significant.
The data suggest it is unlikely that alterations in the expression of either ER are commonly involved in the progression of prostate cancer.</abstract><cop>United States</cop><pmid>12692783</pmid><tpages>7</tpages></addata></record> |
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| subjects | Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma - genetics Carcinoma - metabolism DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Estrogen Receptor alpha Estrogen Receptor beta Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Receptors, Estrogen - biosynthesis Receptors, Estrogen - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumor Cells, Cultured |
| title | Expression of ERalpha and ERbeta in prostate cancer |
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