Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model
To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery. Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA. Corneal flaps with a nasal or a temporal hinge were created in 19...
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| Veröffentlicht in: | Journal of cataract and refractive surgery 2003-04, Vol.29 (4), p.795-802 |
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| container_title | Journal of cataract and refractive surgery |
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| creator | Holzer, Mike P Vargas, Luis G Sandoval, Helga P Vroman, David T Kasper, Terrance J Brown, Sandra J Apple, David J Solomon, Kerry D |
| description | To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery.
Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.
Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper
® microkeratome (Bausch & Lomb Surgical). Diffuse lamellar keratitis (DLK) was induced by inoculating the corneal interfaces with 1 of 7 substances. Postoperatively, the eyes were examined with a slitlamp. Special emphasis was placed on corneal flap complications and the relationship between slipped flaps and hinge position and/or inoculation agent.
A good corneal flap was achieved in 174 eyes (92%). The eyes with a nasal hinge had a lower incidence of slipped flaps (14%) than eyes with a temporal hinge (37%) (
P = .02).
With the animal model described, corneal flaps were created in a precise and reproducible way in more than 90% of eyes. Nasal hinged flaps showed less postoperative displacements than temporal hinged flaps and are adequate for further study. |
| doi_str_mv | 10.1016/S0886-3350(03)00096-8 |
| format | Article |
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Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.
Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper
® microkeratome (Bausch & Lomb Surgical). Diffuse lamellar keratitis (DLK) was induced by inoculating the corneal interfaces with 1 of 7 substances. Postoperatively, the eyes were examined with a slitlamp. Special emphasis was placed on corneal flap complications and the relationship between slipped flaps and hinge position and/or inoculation agent.
A good corneal flap was achieved in 174 eyes (92%). The eyes with a nasal hinge had a lower incidence of slipped flaps (14%) than eyes with a temporal hinge (37%) (
P = .02).
With the animal model described, corneal flaps were created in a precise and reproducible way in more than 90% of eyes. Nasal hinged flaps showed less postoperative displacements than temporal hinged flaps and are adequate for further study.</description><identifier>ISSN: 0886-3350</identifier><identifier>EISSN: 1873-4502</identifier><identifier>DOI: 10.1016/S0886-3350(03)00096-8</identifier><identifier>PMID: 12686252</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Corneal Stroma - surgery ; Disease Models, Animal ; Intraoperative Complications ; Keratitis - etiology ; Postoperative Complications ; Rabbits ; Refractive Surgical Procedures ; Surgical Flaps - adverse effects</subject><ispartof>Journal of cataract and refractive surgery, 2003-04, Vol.29 (4), p.795-802</ispartof><rights>2003 ASCRS and ESCRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-470619f23ddfbc0dc3a82a0a081577cce8b1f45f8f6cb13378fa25b057c89cf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0886335003000968$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12686252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holzer, Mike P</creatorcontrib><creatorcontrib>Vargas, Luis G</creatorcontrib><creatorcontrib>Sandoval, Helga P</creatorcontrib><creatorcontrib>Vroman, David T</creatorcontrib><creatorcontrib>Kasper, Terrance J</creatorcontrib><creatorcontrib>Brown, Sandra J</creatorcontrib><creatorcontrib>Apple, David J</creatorcontrib><creatorcontrib>Solomon, Kerry D</creatorcontrib><title>Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model</title><title>Journal of cataract and refractive surgery</title><addtitle>J Cataract Refract Surg</addtitle><description>To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery.
Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.
Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper
® microkeratome (Bausch & Lomb Surgical). Diffuse lamellar keratitis (DLK) was induced by inoculating the corneal interfaces with 1 of 7 substances. Postoperatively, the eyes were examined with a slitlamp. Special emphasis was placed on corneal flap complications and the relationship between slipped flaps and hinge position and/or inoculation agent.
A good corneal flap was achieved in 174 eyes (92%). The eyes with a nasal hinge had a lower incidence of slipped flaps (14%) than eyes with a temporal hinge (37%) (
P = .02).
With the animal model described, corneal flaps were created in a precise and reproducible way in more than 90% of eyes. Nasal hinged flaps showed less postoperative displacements than temporal hinged flaps and are adequate for further study.</description><subject>Animals</subject><subject>Corneal Stroma - surgery</subject><subject>Disease Models, Animal</subject><subject>Intraoperative Complications</subject><subject>Keratitis - etiology</subject><subject>Postoperative Complications</subject><subject>Rabbits</subject><subject>Refractive Surgical Procedures</subject><subject>Surgical Flaps - adverse effects</subject><issn>0886-3350</issn><issn>1873-4502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4eQclKdFE9SSZt6kZk8AaCgroOaXoikbapSWfQt7fjDLp0deDw_efyEXLI4IwBy8-fQak8E0LCCYhTACjzTG2QCVOFyKYS-CaZ_CI7ZDel9xGaciG3yQ7jucq55BOCsxA7NA11jempDW3feGsGH7pEfUcjumjs4BdI0zy-Yfy6oE8mDpRd0BoX2IS-xW6gwVHTUfzsMfplYxxoOt-OpQ01Nvtky5km4cG67pHXm-uX2V328Hh7P7t6yKyAcsimBeSsdFzUtass1FYYxQ0YUEwWhbWoKuam0imX24oJUShnuKxAFlaV1pVijxyv5vYxfMwxDbr1yWLTmA7DPOlCsFJwrkZQrkAbQ0rjl7ofDzfxSzPQS7_6x69eytMg9I9fvcwdrRfMqxbrv9Ra6AhcrgAc31x4jDpZj53F2ke0g66D_2fFN-5di3w</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Holzer, Mike P</creator><creator>Vargas, Luis G</creator><creator>Sandoval, Helga P</creator><creator>Vroman, David T</creator><creator>Kasper, Terrance J</creator><creator>Brown, Sandra J</creator><creator>Apple, David J</creator><creator>Solomon, Kerry D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model</title><author>Holzer, Mike P ; Vargas, Luis G ; Sandoval, Helga P ; Vroman, David T ; Kasper, Terrance J ; Brown, Sandra J ; Apple, David J ; Solomon, Kerry D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-470619f23ddfbc0dc3a82a0a081577cce8b1f45f8f6cb13378fa25b057c89cf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Corneal Stroma - surgery</topic><topic>Disease Models, Animal</topic><topic>Intraoperative Complications</topic><topic>Keratitis - etiology</topic><topic>Postoperative Complications</topic><topic>Rabbits</topic><topic>Refractive Surgical Procedures</topic><topic>Surgical Flaps - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holzer, Mike P</creatorcontrib><creatorcontrib>Vargas, Luis G</creatorcontrib><creatorcontrib>Sandoval, Helga P</creatorcontrib><creatorcontrib>Vroman, David T</creatorcontrib><creatorcontrib>Kasper, Terrance J</creatorcontrib><creatorcontrib>Brown, Sandra J</creatorcontrib><creatorcontrib>Apple, David J</creatorcontrib><creatorcontrib>Solomon, Kerry D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cataract and refractive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holzer, Mike P</au><au>Vargas, Luis G</au><au>Sandoval, Helga P</au><au>Vroman, David T</au><au>Kasper, Terrance J</au><au>Brown, Sandra J</au><au>Apple, David J</au><au>Solomon, Kerry D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model</atitle><jtitle>Journal of cataract and refractive surgery</jtitle><addtitle>J Cataract Refract Surg</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>29</volume><issue>4</issue><spage>795</spage><epage>802</epage><pages>795-802</pages><issn>0886-3350</issn><eissn>1873-4502</eissn><abstract>To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery.
Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.
Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper
® microkeratome (Bausch & Lomb Surgical). Diffuse lamellar keratitis (DLK) was induced by inoculating the corneal interfaces with 1 of 7 substances. Postoperatively, the eyes were examined with a slitlamp. Special emphasis was placed on corneal flap complications and the relationship between slipped flaps and hinge position and/or inoculation agent.
A good corneal flap was achieved in 174 eyes (92%). The eyes with a nasal hinge had a lower incidence of slipped flaps (14%) than eyes with a temporal hinge (37%) (
P = .02).
With the animal model described, corneal flaps were created in a precise and reproducible way in more than 90% of eyes. Nasal hinged flaps showed less postoperative displacements than temporal hinged flaps and are adequate for further study.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12686252</pmid><doi>10.1016/S0886-3350(03)00096-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of cataract and refractive surgery, 2003-04, Vol.29 (4), p.795-802 |
| issn | 0886-3350 1873-4502 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Corneal Stroma - surgery Disease Models, Animal Intraoperative Complications Keratitis - etiology Postoperative Complications Rabbits Refractive Surgical Procedures Surgical Flaps - adverse effects |
| title | Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model |
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