Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia
We sought to determine whether menopausal status or postmenopausal hypercholesterolemia affects forearm resistance artery endothelial function. We studied the forearm resistance artery endothelial function in 75 Japanese women: 25 premenopausal volunteers, 25 postmenopausal women with normal serum l...
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| Veröffentlicht in: | Maturitas 2003-04, Vol.44 (4), p.307-315 |
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| creator | Sanada, Mitsuhiro Higashi, Yukihito Nakagawa, Keigo Kodama, Ichiro Tsuda, Mikio Nagai, Nobutaka Chayama, Kazuaki Ohama, Koso |
| description | We sought to determine whether menopausal status or postmenopausal hypercholesterolemia affects forearm resistance artery endothelial function. We studied the forearm resistance artery endothelial function in 75 Japanese women: 25 premenopausal volunteers, 25 postmenopausal women with normal serum low-density lipoprotein (LDL) cholesterol concentrations, and 25 hypercholesterolemic postmenopausal women. Excluded from the study were patients with hypertriglyceridemia, hypertension, or diabetes, cigarette smokers. The forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. The serum concentrations of lipoprotein (a) [Lp(a)] were significantly higher in the hypercholesterolemic postmenopausal group than in the other two groups (
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| doi_str_mv | 10.1016/S0378-5122(03)00045-8 |
| format | Article |
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P<0.01). These lipid parameters were similar between the premenopausal and postmenopausal women with normal cholesterol. The FBF responses to reactive hyperemia were significantly lower in the postmenopausal hypercholesterolemic women than in the other two groups (
P<0.01). The reactive hyperemia also was impaired in the postmenopausal group with normal cholesterol as compared with the premenopausal group (
P<0.01). Increases in FBF after NTG were similar between the three groups. By stepwise multivariate analysis, menopausal status and serum LDL cholesterol was the significant predictor of forearm endothelial function. These findings suggest that reactive hyperemia is impaired in forearm resistance arteries after menopause, especially in postmenopausal women with hypercholesterolemia.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/S0378-5122(03)00045-8</identifier><identifier>PMID: 12697372</identifier><identifier>CODEN: MATUDK</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Flow Velocity ; Disorders of blood lipids. Hyperlipoproteinemia ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Endothelium, Vascular - physiopathology ; Female ; Forearm - blood supply ; Forearm resistance artery endothelial function ; Gynecology. Andrology. Obstetrics ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - physiopathology ; Medical sciences ; Metabolic diseases ; Middle Aged ; Nitroglycerin - pharmacology ; Plethysmography ; Postmenopause ; Postmenopause - physiology ; Premenopause ; Premenopause - physiology ; Puberal and climacteric disorders (male and female) ; Vascular Resistance ; Vasodilation ; Vasodilator Agents - pharmacology</subject><ispartof>Maturitas, 2003-04, Vol.44 (4), p.307-315</ispartof><rights>2003 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-795e75e1a82cf8ec82c9bec33b52bf6f007169f6528312ca6c9877e33e918fa13</citedby><cites>FETCH-LOGICAL-c391t-795e75e1a82cf8ec82c9bec33b52bf6f007169f6528312ca6c9877e33e918fa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-5122(03)00045-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14782480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12697372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanada, Mitsuhiro</creatorcontrib><creatorcontrib>Higashi, Yukihito</creatorcontrib><creatorcontrib>Nakagawa, Keigo</creatorcontrib><creatorcontrib>Kodama, Ichiro</creatorcontrib><creatorcontrib>Tsuda, Mikio</creatorcontrib><creatorcontrib>Nagai, Nobutaka</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Ohama, Koso</creatorcontrib><title>Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>We sought to determine whether menopausal status or postmenopausal hypercholesterolemia affects forearm resistance artery endothelial function. We studied the forearm resistance artery endothelial function in 75 Japanese women: 25 premenopausal volunteers, 25 postmenopausal women with normal serum low-density lipoprotein (LDL) cholesterol concentrations, and 25 hypercholesterolemic postmenopausal women. Excluded from the study were patients with hypertriglyceridemia, hypertension, or diabetes, cigarette smokers. The forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. The serum concentrations of lipoprotein (a) [Lp(a)] were significantly higher in the hypercholesterolemic postmenopausal group than in the other two groups (
P<0.01). These lipid parameters were similar between the premenopausal and postmenopausal women with normal cholesterol. The FBF responses to reactive hyperemia were significantly lower in the postmenopausal hypercholesterolemic women than in the other two groups (
P<0.01). The reactive hyperemia also was impaired in the postmenopausal group with normal cholesterol as compared with the premenopausal group (
P<0.01). Increases in FBF after NTG were similar between the three groups. By stepwise multivariate analysis, menopausal status and serum LDL cholesterol was the significant predictor of forearm endothelial function. These findings suggest that reactive hyperemia is impaired in forearm resistance arteries after menopause, especially in postmenopausal women with hypercholesterolemia.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Forearm resistance artery endothelial function</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Hypercholesterolemia - physiopathology</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Nitroglycerin - pharmacology</subject><subject>Plethysmography</subject><subject>Postmenopause</subject><subject>Postmenopause - physiology</subject><subject>Premenopause</subject><subject>Premenopause - physiology</subject><subject>Puberal and climacteric disorders (male and female)</subject><subject>Vascular Resistance</subject><subject>Vasodilation</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwD5AoJDij_i2DkhtOJLqtQDcLYcZ6w1SuxgO1310t-Ou7ui3Hp65ZlnxqMHoVeUXFJCuw8_CJeqEZSxd4S_J4S0olFP0IYqyZuWUvoUbf4hZ-g8598VEoS3z9EZZV0vuWQbdLeN82KSzzHg6LCLCUyaMYQxlh1M3kzYrcEWX_sDlD1AwEuCGUJczJpr24QRLzGX_0r7WB9478sOx3TIuBa8u10g2V2cIBdINWZvXqBnzkwZXp7yAv368vnn9ltzdf31-_bTVWN5T0sjewFSADWKWafA1ugHsJwPgg2uc4RI2vWuE0xxyqzpbK-kBM6hp8oZyi_Q2-PeJcU_az1Azz5bmCYTIK5ZS057JlhbQXEEbYo5J3B6SX426VZTou_F64N4fW9VE64P4rWqc69PH6zDDOPD1Ml0Bd6cAJOtmVwywfr8wLVSsVaRyn08clB13HhIOlsPwcLoE9iix-gfOeUv3dSjTg</recordid><startdate>20030425</startdate><enddate>20030425</enddate><creator>Sanada, Mitsuhiro</creator><creator>Higashi, Yukihito</creator><creator>Nakagawa, Keigo</creator><creator>Kodama, Ichiro</creator><creator>Tsuda, Mikio</creator><creator>Nagai, Nobutaka</creator><creator>Chayama, Kazuaki</creator><creator>Ohama, Koso</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030425</creationdate><title>Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia</title><author>Sanada, Mitsuhiro ; Higashi, Yukihito ; Nakagawa, Keigo ; Kodama, Ichiro ; Tsuda, Mikio ; Nagai, Nobutaka ; Chayama, Kazuaki ; Ohama, Koso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-795e75e1a82cf8ec82c9bec33b52bf6f007169f6528312ca6c9877e33e918fa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Forearm resistance artery endothelial function</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypercholesterolemia</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Nitroglycerin - pharmacology</topic><topic>Plethysmography</topic><topic>Postmenopause</topic><topic>Postmenopause - physiology</topic><topic>Premenopause</topic><topic>Premenopause - physiology</topic><topic>Puberal and climacteric disorders (male and female)</topic><topic>Vascular Resistance</topic><topic>Vasodilation</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanada, Mitsuhiro</creatorcontrib><creatorcontrib>Higashi, Yukihito</creatorcontrib><creatorcontrib>Nakagawa, Keigo</creatorcontrib><creatorcontrib>Kodama, Ichiro</creatorcontrib><creatorcontrib>Tsuda, Mikio</creatorcontrib><creatorcontrib>Nagai, Nobutaka</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Ohama, Koso</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanada, Mitsuhiro</au><au>Higashi, Yukihito</au><au>Nakagawa, Keigo</au><au>Kodama, Ichiro</au><au>Tsuda, Mikio</au><au>Nagai, Nobutaka</au><au>Chayama, Kazuaki</au><au>Ohama, Koso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>2003-04-25</date><risdate>2003</risdate><volume>44</volume><issue>4</issue><spage>307</spage><epage>315</epage><pages>307-315</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><coden>MATUDK</coden><abstract>We sought to determine whether menopausal status or postmenopausal hypercholesterolemia affects forearm resistance artery endothelial function. We studied the forearm resistance artery endothelial function in 75 Japanese women: 25 premenopausal volunteers, 25 postmenopausal women with normal serum low-density lipoprotein (LDL) cholesterol concentrations, and 25 hypercholesterolemic postmenopausal women. Excluded from the study were patients with hypertriglyceridemia, hypertension, or diabetes, cigarette smokers. The forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography. The serum concentrations of lipoprotein (a) [Lp(a)] were significantly higher in the hypercholesterolemic postmenopausal group than in the other two groups (
P<0.01). These lipid parameters were similar between the premenopausal and postmenopausal women with normal cholesterol. The FBF responses to reactive hyperemia were significantly lower in the postmenopausal hypercholesterolemic women than in the other two groups (
P<0.01). The reactive hyperemia also was impaired in the postmenopausal group with normal cholesterol as compared with the premenopausal group (
P<0.01). Increases in FBF after NTG were similar between the three groups. By stepwise multivariate analysis, menopausal status and serum LDL cholesterol was the significant predictor of forearm endothelial function. These findings suggest that reactive hyperemia is impaired in forearm resistance arteries after menopause, especially in postmenopausal women with hypercholesterolemia.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12697372</pmid><doi>10.1016/S0378-5122(03)00045-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | Maturitas, 2003-04, Vol.44 (4), p.307-315 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Blood Flow Velocity Disorders of blood lipids. Hyperlipoproteinemia Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Endothelium, Vascular - physiopathology Female Forearm - blood supply Forearm resistance artery endothelial function Gynecology. Andrology. Obstetrics Humans Hypercholesterolemia Hypercholesterolemia - physiopathology Medical sciences Metabolic diseases Middle Aged Nitroglycerin - pharmacology Plethysmography Postmenopause Postmenopause - physiology Premenopause Premenopause - physiology Puberal and climacteric disorders (male and female) Vascular Resistance Vasodilation Vasodilator Agents - pharmacology |
| title | Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia |
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