Cytokine Release from Microglia: Differential Inhibition by Pentoxifylline and Dexamethasone

Cytokines have been implicated in the pathogenesis of gram-negative bacterial meningitis. The effects of pentoxifylline and dexamethasone on the release of tumor necrosis factor (TNF), interleukin (IL)-1, and IL-6 from primary murine microglial cell cultures were explored using bioassays. When added...

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Veröffentlicht in:	The Journal of infectious diseases 1992-10, Vol.166 (4), p.847-853
Hauptverfasser:	Chao, Chun C., Hu, Shuxian, Close, Karen, Choi, Chang S., Molitor, Thomas W., Novick, William J., Peterson, Phillip K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial meningitis Bioassay Biological and medical sciences Brain - drug effects Brain - metabolism Cell culture techniques Cells, Cultured Central nervous system Cytokines Dexamethasone - pharmacology Haemophilus meningitis Inflammation Interleukin-1 - metabolism Interleukin-6 - metabolism Interleukins Lipopolysaccharides Major Articles Medical sciences Mice Mice, Inbred BALB C Microglia Miscellaneous Neuropharmacology Pentoxifylline - pharmacology Pharmacology. Drug treatments Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factors
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