Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida
The effects of the antiarthritic drugs aurothiomalate (AuTm), aurothioglucose (AuTg), auranofin, its metabolite triethylphosphinegold(I)thioglucose (Et 3PAuTg), and several related complexes on the growth of Pseudomonas putida were studied. Two strains were used, one of which (BK135) was more sensit...
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| Veröffentlicht in: | Journal of inorganic biochemistry 1992-05, Vol.46 (2), p.129-142 |
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| container_title | Journal of inorganic biochemistry |
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| creator | Rhodes, Michael D. Sadler, Peter J. Scawen, Michael D. Silver, Simon |
| description | The effects of the antiarthritic drugs aurothiomalate (AuTm), aurothioglucose (AuTg), auranofin, its metabolite triethylphosphinegold(I)thioglucose (Et
3PAuTg), and several related complexes on the growth of
Pseudomonas putida were studied. Two strains were used, one of which (BK135) was more sensitive to Et
3PAuTg (tolerant up to 4 μM) than the other (BK403; tolerant to at least 500 μM). Gold thiolate complexes and thiolate ligands alone had little effect on growth. Gold phosphine complexes increased the length of the lag phase of growth and reduced oxygen uptake. Marked changes in cellular morphology were determined by electron microscopy. Copper(II) compounds and aurothiomalate were synergistic in their growth inhibitory effects towards these bacteria. Experiments with
195Au suggested that a mechanism does not exist for the short term (minutes) uptake of gold by sensitive or resistant bacteria, but the resistant strain appeared to limit gold uptake over a longer term (hours). |
| doi_str_mv | 10.1016/0162-0134(92)80016-O |
| format | Article |
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3PAuTg), and several related complexes on the growth of
Pseudomonas putida were studied. Two strains were used, one of which (BK135) was more sensitive to Et
3PAuTg (tolerant up to 4 μM) than the other (BK403; tolerant to at least 500 μM). Gold thiolate complexes and thiolate ligands alone had little effect on growth. Gold phosphine complexes increased the length of the lag phase of growth and reduced oxygen uptake. Marked changes in cellular morphology were determined by electron microscopy. Copper(II) compounds and aurothiomalate were synergistic in their growth inhibitory effects towards these bacteria. Experiments with
195Au suggested that a mechanism does not exist for the short term (minutes) uptake of gold by sensitive or resistant bacteria, but the resistant strain appeared to limit gold uptake over a longer term (hours).</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/0162-0134(92)80016-O</identifier><identifier>PMID: 1355789</identifier><identifier>CODEN: JIBIDJ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antirheumatic Agents - pharmacology ; Auranofin - pharmacology ; Aurothioglucose - pharmacology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Gold Radioisotopes ; Gold Sodium Thiomalate - pharmacology ; Hydrogen-Ion Concentration ; Medical sciences ; Microscopy, Electron ; Oxygen Consumption ; Pharmacology. Drug treatments ; Pseudomonas putida - drug effects ; Pseudomonas putida - growth & development ; Pseudomonas putida - ultrastructure</subject><ispartof>Journal of inorganic biochemistry, 1992-05, Vol.46 (2), p.129-142</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-a40e9af2876e40a41cc4793c81babed9cf1680c39fcfff8386e396097fb3f9463</citedby><cites>FETCH-LOGICAL-c452t-a40e9af2876e40a41cc4793c81babed9cf1680c39fcfff8386e396097fb3f9463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016201349280016O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4306598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1355789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rhodes, Michael D.</creatorcontrib><creatorcontrib>Sadler, Peter J.</creatorcontrib><creatorcontrib>Scawen, Michael D.</creatorcontrib><creatorcontrib>Silver, Simon</creatorcontrib><title>Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The effects of the antiarthritic drugs aurothiomalate (AuTm), aurothioglucose (AuTg), auranofin, its metabolite triethylphosphinegold(I)thioglucose (Et
3PAuTg), and several related complexes on the growth of
Pseudomonas putida were studied. Two strains were used, one of which (BK135) was more sensitive to Et
3PAuTg (tolerant up to 4 μM) than the other (BK403; tolerant to at least 500 μM). Gold thiolate complexes and thiolate ligands alone had little effect on growth. Gold phosphine complexes increased the length of the lag phase of growth and reduced oxygen uptake. Marked changes in cellular morphology were determined by electron microscopy. Copper(II) compounds and aurothiomalate were synergistic in their growth inhibitory effects towards these bacteria. Experiments with
195Au suggested that a mechanism does not exist for the short term (minutes) uptake of gold by sensitive or resistant bacteria, but the resistant strain appeared to limit gold uptake over a longer term (hours).</description><subject>Antirheumatic Agents - pharmacology</subject><subject>Auranofin - pharmacology</subject><subject>Aurothioglucose - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Gold Radioisotopes</subject><subject>Gold Sodium Thiomalate - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Oxygen Consumption</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas putida - drug effects</subject><subject>Pseudomonas putida - growth & development</subject><subject>Pseudomonas putida - ultrastructure</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWj_-gcIeRNrDarLJ7iYXQaR-gFARPYc0mdTI7qYmu4L_3tSWevMwhMk87zA8CJ0SfEkwqa5SFTkmlI1FMeE4tflsB40Ir2lOKWO7aLRFDtBhjB8Y47Jk9T7aJ7Qsay5G6GVqLeg-Zt5mC9-Y8eMkU13vVOjfg-udzkwYFjH9mSxAo3owmfbt0g-dSaEue44wGN_6TsVsOfTOqGO0Z1UT4WTzHqG3u-nr7UP-NLt_vL15yjUriz5XDINQtuB1BQwrRrRmtaCak7magxHakopjTYXV1lpOeQVUVFjUdk6tYBU9QhfrvcvgPweIvWxd1NA0qgM_RFlTInBBRALZGtTBxxjAymVwrQrfkmC5UilXnuTKkxSF_FUpZyl2ttk_zFswf6G1uzQ_38xV1KqxQXXaxS3GKK5KwRN2vcYgufhyEGTUDjoNxoVkXhrv_r_jB6w2j8s</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Rhodes, Michael D.</creator><creator>Sadler, Peter J.</creator><creator>Scawen, Michael D.</creator><creator>Silver, Simon</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida</title><author>Rhodes, Michael D. ; Sadler, Peter J. ; Scawen, Michael D. ; Silver, Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-a40e9af2876e40a41cc4793c81babed9cf1680c39fcfff8386e396097fb3f9463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antirheumatic Agents - pharmacology</topic><topic>Auranofin - pharmacology</topic><topic>Aurothioglucose - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Gold Radioisotopes</topic><topic>Gold Sodium Thiomalate - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Oxygen Consumption</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas putida - drug effects</topic><topic>Pseudomonas putida - growth & development</topic><topic>Pseudomonas putida - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rhodes, Michael D.</creatorcontrib><creatorcontrib>Sadler, Peter J.</creatorcontrib><creatorcontrib>Scawen, Michael D.</creatorcontrib><creatorcontrib>Silver, Simon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rhodes, Michael D.</au><au>Sadler, Peter J.</au><au>Scawen, Michael D.</au><au>Silver, Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>46</volume><issue>2</issue><spage>129</spage><epage>142</epage><pages>129-142</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><coden>JIBIDJ</coden><abstract>The effects of the antiarthritic drugs aurothiomalate (AuTm), aurothioglucose (AuTg), auranofin, its metabolite triethylphosphinegold(I)thioglucose (Et
3PAuTg), and several related complexes on the growth of
Pseudomonas putida were studied. Two strains were used, one of which (BK135) was more sensitive to Et
3PAuTg (tolerant up to 4 μM) than the other (BK403; tolerant to at least 500 μM). Gold thiolate complexes and thiolate ligands alone had little effect on growth. Gold phosphine complexes increased the length of the lag phase of growth and reduced oxygen uptake. Marked changes in cellular morphology were determined by electron microscopy. Copper(II) compounds and aurothiomalate were synergistic in their growth inhibitory effects towards these bacteria. Experiments with
195Au suggested that a mechanism does not exist for the short term (minutes) uptake of gold by sensitive or resistant bacteria, but the resistant strain appeared to limit gold uptake over a longer term (hours).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1355789</pmid><doi>10.1016/0162-0134(92)80016-O</doi><tpages>14</tpages></addata></record> |
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| ispartof | Journal of inorganic biochemistry, 1992-05, Vol.46 (2), p.129-142 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antirheumatic Agents - pharmacology Auranofin - pharmacology Aurothioglucose - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Gold Radioisotopes Gold Sodium Thiomalate - pharmacology Hydrogen-Ion Concentration Medical sciences Microscopy, Electron Oxygen Consumption Pharmacology. Drug treatments Pseudomonas putida - drug effects Pseudomonas putida - growth & development Pseudomonas putida - ultrastructure |
| title | Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putida |
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