Dietary Sodium and the Antihypertensive Effect of Nifedipine in Spontaneously Hypertensive Rats
To assess the interaction of dietary sodium and the antihypertensive response to a calcium antagonist, spontaneously hypertensive rats (SHR) were given a diet of regular or increased (120 ν 342 μmol Na+ /g food) sodium intake from 4 until 16 weeks of age. Nifedipine was added at 10 weeks of age. Thi...
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| Veröffentlicht in: | American journal of hypertension 1992-08, Vol.5 (8), p.515-519 |
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| creator | Leenen, Frans H.H. Yuan, Baoxue |
| description | To assess the interaction of dietary sodium and the antihypertensive response to a calcium antagonist, spontaneously hypertensive rats (SHR) were given a diet of regular or increased (120 ν 342 μmol Na+ /g food) sodium intake from 4 until 16 weeks of age. Nifedipine was added at 10 weeks of age. This level of sodium intake did not enhance the development of hypertension in SHR. In rats with the regular sodium intake, nifedipine caused only a minor decrease in blood pressure. In contrast, with increased sodium intake nifedipine caused a marked antihypertensive response, preventing the rise in blood pressure occurring between 10 and 16 weeks of age. This enhanced response was associated with a diminished blood pressure fall from ganglionic blockade. These results indicate that modest increases in sodium intake enhance the blood pressure response to a calcium antagonist possibly by potentiating its inhibitory effects on sympathetic activity. Am J Hypertens 1992;5:515–519 |
| doi_str_mv | 10.1093/ajh/5.8.515 |
| format | Article |
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Nifedipine was added at 10 weeks of age. This level of sodium intake did not enhance the development of hypertension in SHR. In rats with the regular sodium intake, nifedipine caused only a minor decrease in blood pressure. In contrast, with increased sodium intake nifedipine caused a marked antihypertensive response, preventing the rise in blood pressure occurring between 10 and 16 weeks of age. This enhanced response was associated with a diminished blood pressure fall from ganglionic blockade. These results indicate that modest increases in sodium intake enhance the blood pressure response to a calcium antagonist possibly by potentiating its inhibitory effects on sympathetic activity. 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Drug treatments ; Phenylephrine - pharmacology ; Rats ; Rats, Inbred SHR - physiology ; Sodium, Dietary - pharmacology ; Sodium, Dietary - therapeutic use ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology</subject><ispartof>American journal of hypertension, 1992-08, Vol.5 (8), p.515-519</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-5523a156a0f926f6abc4526aa289a2b119dfa1365102377af0f0ece13c0bb3703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5487509$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1388961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leenen, Frans H.H.</creatorcontrib><creatorcontrib>Yuan, Baoxue</creatorcontrib><title>Dietary Sodium and the Antihypertensive Effect of Nifedipine in Spontaneously Hypertensive Rats</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>To assess the interaction of dietary sodium and the antihypertensive response to a calcium antagonist, spontaneously hypertensive rats (SHR) were given a diet of regular or increased (120 ν 342 μmol Na+ /g food) sodium intake from 4 until 16 weeks of age. Nifedipine was added at 10 weeks of age. This level of sodium intake did not enhance the development of hypertension in SHR. In rats with the regular sodium intake, nifedipine caused only a minor decrease in blood pressure. In contrast, with increased sodium intake nifedipine caused a marked antihypertensive response, preventing the rise in blood pressure occurring between 10 and 16 weeks of age. This enhanced response was associated with a diminished blood pressure fall from ganglionic blockade. These results indicate that modest increases in sodium intake enhance the blood pressure response to a calcium antagonist possibly by potentiating its inhibitory effects on sympathetic activity. Am J Hypertens 1992;5:515–519</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>calcium antagonist</subject><subject>Cardiovascular system</subject><subject>Dietary sodium</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Heart Ventricles - pathology</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nifedipine</subject><subject>Nifedipine - pharmacology</subject><subject>Nifedipine - therapeutic use</subject><subject>Organ Size - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR - physiology</subject><subject>Sodium, Dietary - pharmacology</subject><subject>Sodium, Dietary - therapeutic use</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtrGzEUhUVJSR23q6wDWpRuyti6kvWYZUiTuBBaqPsiG3FHI2Gl45nJSC71v--UMWlWd3G-c7h8hJwDWwArxRIftku5MAsJ8gWZQbmCQnMuT8iMmVIWmil4Rc5SemCMrZSCU3IKwphSwYzYD9FnHA5009Vxv6PY1jRvPb1sc9weej9k36b429PrELzLtAv0Uwy-jn1sPY0t3fRdm7H13T41B7p-XvmCOb0mLwM2yb853jn5dnP99Wpd3H2-_Xh1eVc4ISEXUnKBIBWyUHIVFFZuJblC5KZEXgGUdUAQSgLjQmsMLDDvPAjHqkpoJubk3bTbD93j3qdsdzE53zTTa1YLMMZwGMH3E-iGLqXBB9sPcTcasMDsP5121GmlNXbUOdIXx9l9tfP1f3byN-Zvjzkmh00YsHUxPWFyZbQcN-ekmLCYsv_zFOPwyyottLTrn_e2XH9n90b_sDfiL_v2jQo</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Leenen, Frans H.H.</creator><creator>Yuan, Baoxue</creator><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Dietary Sodium and the Antihypertensive Effect of Nifedipine in Spontaneously Hypertensive Rats</title><author>Leenen, Frans H.H. ; Yuan, Baoxue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-5523a156a0f926f6abc4526aa289a2b119dfa1365102377af0f0ece13c0bb3703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>calcium antagonist</topic><topic>Cardiovascular system</topic><topic>Dietary sodium</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Heart Ventricles - pathology</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>nifedipine</topic><topic>Nifedipine - pharmacology</topic><topic>Nifedipine - therapeutic use</topic><topic>Organ Size - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR - physiology</topic><topic>Sodium, Dietary - pharmacology</topic><topic>Sodium, Dietary - therapeutic use</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leenen, Frans H.H.</creatorcontrib><creatorcontrib>Yuan, Baoxue</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leenen, Frans H.H.</au><au>Yuan, Baoxue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Sodium and the Antihypertensive Effect of Nifedipine in Spontaneously Hypertensive Rats</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>5</volume><issue>8</issue><spage>515</spage><epage>519</epage><pages>515-519</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><abstract>To assess the interaction of dietary sodium and the antihypertensive response to a calcium antagonist, spontaneously hypertensive rats (SHR) were given a diet of regular or increased (120 ν 342 μmol Na+ /g food) sodium intake from 4 until 16 weeks of age. Nifedipine was added at 10 weeks of age. This level of sodium intake did not enhance the development of hypertension in SHR. In rats with the regular sodium intake, nifedipine caused only a minor decrease in blood pressure. In contrast, with increased sodium intake nifedipine caused a marked antihypertensive response, preventing the rise in blood pressure occurring between 10 and 16 weeks of age. This enhanced response was associated with a diminished blood pressure fall from ganglionic blockade. These results indicate that modest increases in sodium intake enhance the blood pressure response to a calcium antagonist possibly by potentiating its inhibitory effects on sympathetic activity. Am J Hypertens 1992;5:515–519</abstract><cop>New York, NY</cop><pub>Oxford University Press</pub><pmid>1388961</pmid><doi>10.1093/ajh/5.8.515</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Aging - physiology Animals Antihypertensive agents Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology calcium antagonist Cardiovascular system Dietary sodium Heart Rate - drug effects Heart Rate - physiology Heart Ventricles - pathology Hemodynamics - drug effects Hemodynamics - physiology Hexamethonium Compounds - pharmacology hypertension Hypertension - drug therapy Hypertension - physiopathology Male Medical sciences nifedipine Nifedipine - pharmacology Nifedipine - therapeutic use Organ Size - drug effects Pharmacology. Drug treatments Phenylephrine - pharmacology Rats Rats, Inbred SHR - physiology Sodium, Dietary - pharmacology Sodium, Dietary - therapeutic use Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology |
| title | Dietary Sodium and the Antihypertensive Effect of Nifedipine in Spontaneously Hypertensive Rats |
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