Nebivolol Prevents Vascular NOS III Uncoupling in Experimental Hyperlipidemia and Inhibits NADPH Oxidase Activity in Inflammatory Cells

OBJECTIVES—Nebivolol, in contrast to other selective β1-adrenergic receptor antagonists like atenolol, improves endothelial function in patients with oxidative stress within vascular tissue. With the present studies we sought to determine whether β receptor blockade with nebivolol may improve endoth...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-04, Vol.23 (4), p.615-621
Hauptverfasser:	Mollnau, Hanke, Schulz, Eberhard, Daiber, Andreas, Baldus, Stephan, Oelze, Matthias, August, Michael, Wendt, Maria, Walter, Ulrich, Geiger, Carolin, Agrawal, Rahul, Kleschyov, Andrei L, Meinertz, Thomas, Münzel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Adult Animals Animals, Inbred Strains Antihypertensive agents Aorta - drug effects Aorta - metabolism Benzopyrans - pharmacology Biological and medical sciences Cardiovascular system Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - genetics Cyclic GMP-Dependent Protein Kinases - biosynthesis Cyclic GMP-Dependent Protein Kinases - genetics Drug Evaluation, Preclinical Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Ethanolamines - pharmacology Gene Expression Regulation - drug effects Guanylate Cyclase Humans Hyperlipidemias - blood Hyperlipidemias - drug therapy Hyperlipidemias - genetics Lipids - blood Macrophages - drug effects Macrophages - metabolism Medical sciences Microfilament Proteins NADPH Oxidases - antagonists & inhibitors Nebivolol Neutrophils - drug effects Neutrophils - enzymology Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type III Oxidative Stress Pharmacology. Drug treatments Phosphoproteins - biosynthesis Phosphoproteins - genetics Rabbits Receptors, Adrenergic, beta-1 - drug effects Receptors, Adrenergic, beta-1 - physiology Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics Soluble Guanylyl Cyclase Superoxides - metabolism Vasodilator Agents - pharmacology
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