Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes

Development of subunit vaccines against respiratory syncytial virus (RSV) for naive human infants is hindered by concerns that immunization with the fusion or attachment (G) proteins will elicit polarized Type 2 T cell responses and cause immunopotentiation upon subsequent natural infection. We inve...

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Veröffentlicht in:	Journal of medical virology 2003-06, Vol.70 (2), p.301-308
Hauptverfasser:	Hancock, Gerald E., Tebbey, Paul W., Scheuer, Catherine A., Pryharski, Karin S., Heers, Kristen M., LaPierre, Natisha A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Viral - blood Biological and medical sciences eosinophil Eosinophilia Epitope Mapping Fundamental and applied biological sciences. Psychology Glycosylation H-2 Antigens - genetics Haplotypes Immunodominant Epitopes Mice Mice, Inbred Strains Microbiology Molecular Sequence Data peptide-mapping Peptides Phenotype Pulmonary Eosinophilia - immunology Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus, Human - immunology Th2 Cells - immunology Type 2 T cells vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - immunology Viral Proteins - chemistry Viral Proteins - immunology Viral Proteins - metabolism Viral Vaccines - immunology Virology
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