Single-chain polymorphism analysis in long QT syndrome using planar waveguide fluorescent biosensors

Rapid detection of single nucleotide polymorphisms (SNPs) has potential applications in both genetic screening and pharmacogenomics. Planar waveguide fluorescent biosensor technology was employed to detect SNPs using a simple hybridization assay with the complementary strand (“capture oligo”) immobi...

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Veröffentlicht in:	Analytical biochemistry 2003-04, Vol.315 (2), p.223-237
Hauptverfasser:	Tolley, Samuel E, Wang, Hsu-kun, Smith, Richard S, Christensen, Douglas A, Herron, James N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques - methods Biosensor Counter ion DNA Evanescent wave Fluorescence Hybridization Ions - chemistry KCNQ Potassium Channels Kinetics Long QT syndrome Long QT Syndrome - genetics Melting point Nucleic Acid Denaturation Nucleic Acid Hybridization Polymorphism Polymorphism, Single Nucleotide - genetics Potassium Channels - genetics Potassium Channels, Voltage-Gated Sensitivity and Specificity SNP Temperature Waveguide
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