High and low affinity NGF receptor mRNAs in human foetal spinal cord and ganglia
The cellular localization of mRNAs encoding the low affinity NGF receptor (here referred to as LANR) and the putative high affinity receptor for NGF, trk, have been studied in the human foetal spinal and sympathetic ganglia, and spinal cord, using in situ hybridization. The receptor mRNAs were highl...
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| Veröffentlicht in: | Neuroreport 1992-08, Vol.3 (8), p.689-692 |
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| creator | Wetmore, Cynthia Bygdeman, Marc Olson, Lars |
| description | The cellular localization of mRNAs encoding the low affinity NGF receptor (here referred to as LANR) and the putative high affinity receptor for NGF, trk, have been studied in the human foetal spinal and sympathetic ganglia, and spinal cord, using in situ hybridization. The receptor mRNAs were highly expressed in the spinal and sympathetic ganglia, with most but not all neurons expressing both LANR and trk mRNA. Spinal nerve rootlets distal to the spinal ganglia expressed LANR but not trk mRNA, confirming the presence of the low affinity receptor in developing Schwann cells. In the spinal cord, LANR mRNA was found throughout the medial and lateral motor columns while, trk mRNA was detected in scattered cells in the dorsal aspect of developing grey matter. |
| doi_str_mv | 10.1097/00001756-199208000-00009 |
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The receptor mRNAs were highly expressed in the spinal and sympathetic ganglia, with most but not all neurons expressing both LANR and trk mRNA. Spinal nerve rootlets distal to the spinal ganglia expressed LANR but not trk mRNA, confirming the presence of the low affinity receptor in developing Schwann cells. In the spinal cord, LANR mRNA was found throughout the medial and lateral motor columns while, trk mRNA was detected in scattered cells in the dorsal aspect of developing grey matter.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199208000-00009</identifier><identifier>PMID: 1325844</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Biological and medical sciences ; Embryology: invertebrates and vertebrates. Teratology ; Fetus ; fetuses ; Fundamental and applied biological sciences. 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The receptor mRNAs were highly expressed in the spinal and sympathetic ganglia, with most but not all neurons expressing both LANR and trk mRNA. Spinal nerve rootlets distal to the spinal ganglia expressed LANR but not trk mRNA, confirming the presence of the low affinity receptor in developing Schwann cells. In the spinal cord, LANR mRNA was found throughout the medial and lateral motor columns while, trk mRNA was detected in scattered cells in the dorsal aspect of developing grey matter.</description><subject>Biological and medical sciences</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Fetus</subject><subject>fetuses</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - physiology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>man</subject><subject>mRNA</subject><subject>nerve growth factor</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Neurons - physiology</subject><subject>Oncogene Proteins - genetics</subject><subject>Organogenesis. Fetal development</subject><subject>Organogenesis. 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The receptor mRNAs were highly expressed in the spinal and sympathetic ganglia, with most but not all neurons expressing both LANR and trk mRNA. Spinal nerve rootlets distal to the spinal ganglia expressed LANR but not trk mRNA, confirming the presence of the low affinity receptor in developing Schwann cells. In the spinal cord, LANR mRNA was found throughout the medial and lateral motor columns while, trk mRNA was detected in scattered cells in the dorsal aspect of developing grey matter.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1325844</pmid><doi>10.1097/00001756-199208000-00009</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroreport, 1992-08, Vol.3 (8), p.689-692 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Fetus fetuses Fundamental and applied biological sciences. Psychology Ganglia, Spinal - embryology Ganglia, Spinal - physiology Humans Immunohistochemistry man mRNA nerve growth factor Nerve Growth Factors - metabolism Neurons - physiology Oncogene Proteins - genetics Organogenesis. Fetal development Organogenesis. Physiological fonctions receptors Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, Nerve Growth Factor RNA, Messenger - analysis RNA, Messenger - genetics RNA, Messenger - metabolism spinal cord Spinal Cord - embryology Spinal Cord - physiology sympathetic ganglia |
| title | High and low affinity NGF receptor mRNAs in human foetal spinal cord and ganglia |
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