Detection and Characterization of T Cells Specific for BDC2.5 T Cell-Stimulating Peptides

Nonobese diabetic (NOD) mice expressing the BDC2.5 TCR transgene are useful for studying type 1 diabetes. Several peptides have been identified that are highly active in stimulating BDC2.5 T cells. Herein, we describe the use of I-Ag7 tetramers containing two such peptides, p79 and p17, to detect an...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-04, Vol.170 (8), p.4011-4020
Hauptverfasser:	You, Sylvaine, Chen, Cyndi, Lee, Wen-Hui, Wu, Chun-Hua, Judkowski, Valeria, Pinilla, Clemencia, Wilson, Darcy B, Liu, Chih-Pin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - chemistry CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation Cell Movement - genetics Cell Movement - immunology Cell Separation Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Dose-Response Relationship, Immunologic Epitopes, T-Lymphocyte - administration & dosage Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Glutamate Decarboxylase - administration & dosage Glutamate Decarboxylase - immunology Glutamate Decarboxylase - metabolism Histocompatibility Antigens Class II - administration & dosage Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Islets of Langerhans - chemistry Islets of Langerhans - immunology Islets of Langerhans - metabolism Isoenzymes - administration & dosage Isoenzymes - immunology Isoenzymes - metabolism Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Biozzi Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Mice, Transgenic - immunology Peptide Fragments - administration & dosage Peptide Fragments - chemical synthesis Peptide Fragments - immunology Protein Binding - genetics Protein Binding - immunology Spleen - chemistry Spleen - immunology Spleen - transplantation T-Lymphocyte Subsets - chemistry T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation
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