Peripheral opioid analgesia in experimental human pain models

This placebo‐controlled, double‐blind crossover study assessed whether exclusive activation of peripheral opioid receptors results in significant pain reduction. To achieve opioid activity restricted to the periphery, we used a short‐term (2 h) low dose infusion of morphine‐6‐β‐glucuronide (M6G) bec...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2003-05, Vol.126 (5), p.1092-1102
Hauptverfasser:	Tegeder, Irmgard, Meier, Silke, Burian, Maria, Schmidt, Helmut, Geisslinger, Gerd, Lötsch, Jörn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics - therapeutic use Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cold Temperature - adverse effects Cross-Over Studies DOMS = delayed onset of muscle soreness Double-Blind Method Electric Stimulation Female Humans Hyperalgesia - drug therapy Hyperalgesia - etiology inflammation Local anesthesia. Pain (treatment) M6G = morphine‐6‐glucuronide Male Medical sciences Morphine Morphine Derivatives - therapeutic use morphine‐6‐glucuronide Muscle Contraction pain Peripheral Nerves - drug effects Peripheral Nerves - metabolism peripheral opioid receptor Receptors, Opioid - drug effects VAS = visual analogue scale
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