Drug-specific immune responses induced by procainamide, hydralazine and isoniazid in guinea-pigs

The drug-induced graft vs host reaction (GVHR) hypothesis requires, as the first step, specific T-cell immune responses to the drug-modified self. Procainamide, isoniazid and hydralazine are known to provoke various allergic reactions including GVHR-like adverse effects in man. We now report that dr...

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Veröffentlicht in:	International journal of immunopharmacology 1992-05, Vol.14 (4), p.673-679
Hauptverfasser:	Katsutani, Naruo, Shionoya, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - blood Biological and medical sciences Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Enzyme-Linked Immunosorbent Assay Female Guinea Pigs Hydralazine - administration & dosage Hydralazine - immunology Isoniazid - administration & dosage Isoniazid - immunology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Ovalbumin - administration & dosage Ovalbumin - immunology Penicillins - administration & dosage Penicillins - immunology Pharmacology. Drug treatments Procainamide - administration & dosage Procainamide - immunology Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - immunology
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