Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin as chiral resolving agent
The latest, single-isomer, sulfated γ-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin that is stable in basic media was used to separate the enantiomers of neutral, weak acid and weak base analytes by capillary electrophoresis in high pH aqueous background electrolyt...
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| Veröffentlicht in: | Journal of Chromatography A 2003-03, Vol.990 (1), p.63-73 |
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| container_title | Journal of Chromatography A |
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| creator | Brent Busby, M Maldonado, Omar Vigh, Gyula |
| description | The latest, single-isomer, sulfated γ-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6-
O-sulfo)-γ-cyclodextrin that is stable in basic media was used to separate the enantiomers of neutral, weak acid and weak base analytes by capillary electrophoresis in high pH aqueous background electrolytes. The effective mobilities and separation selectivities were found to follow trends similar to those observed earlier in acidic aqueous background electrolytes. Octakis(2,3-dimethyl-6-
O-sulfo)-γ-cyclodextrin proved to interact with all three analyte types less strongly than other single-isomer sulfated cyclodextrins do under comparable conditions. |
| doi_str_mv | 10.1016/S0021-9673(02)01797-1 |
| format | Article |
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O-sulfo)-γ-cyclodextrin proved to interact with all three analyte types less strongly than other single-isomer sulfated cyclodextrins do under comparable conditions.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(02)01797-1</identifier><identifier>PMID: 12685584</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cyclodextrins ; Cyclodextrins - chemistry ; Electrophoresis, Capillary - methods ; gamma-Cyclodextrins ; Hydrogen-Ion Concentration ; Octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin ; Stereoisomerism ; Sulfated cyclodextrins</subject><ispartof>Journal of Chromatography A, 2003-03, Vol.990 (1), p.63-73</ispartof><rights>2002 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-da7b373d5665922650a150b45f22cd761495d0c0aee0ba47eca443bd771a18253</citedby><cites>FETCH-LOGICAL-c361t-da7b373d5665922650a150b45f22cd761495d0c0aee0ba47eca443bd771a18253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9673(02)01797-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12685584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brent Busby, M</creatorcontrib><creatorcontrib>Maldonado, Omar</creatorcontrib><creatorcontrib>Vigh, Gyula</creatorcontrib><title>Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin as chiral resolving agent</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>The latest, single-isomer, sulfated γ-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6-
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O-sulfo)-γ-cyclodextrin proved to interact with all three analyte types less strongly than other single-isomer sulfated cyclodextrins do under comparable conditions.</description><subject>Cyclodextrins</subject><subject>Cyclodextrins - chemistry</subject><subject>Electrophoresis, Capillary - methods</subject><subject>gamma-Cyclodextrins</subject><subject>Hydrogen-Ion Concentration</subject><subject>Octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin</subject><subject>Stereoisomerism</subject><subject>Sulfated cyclodextrins</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1uFDEQhb0AkRA4AsgrlEgxsd1te2aFoigkkSJlEVhbbrtm2uC2G9sdmKNwDu7Bmej5ESxZlarqvSpVfQi9YfQ9o0xePFLKGVlK1ZxSfkaZWirCnqHjv-Uj9LKUL3TuUMVfoCPG5UKIRXuMfl4HsDWnsU8ZqrcYoonVpwEyLjCabOYkFmwq7v26x-MtnoqPa1x7wBG-n-NtFoD4svMkW81XX075eUOcH6D2m0AkwQ-kTGGVzsjvX8RubEgOftTsIzYF295nE3CGksLTdrZZQ6yv0POVCQVeH-IJ-vzx-tPVLbl_uLm7urwntpGsEmdU16jGCSnFknMpqGGCdq1YcW6dkqxdCkctNQC0M60Ca9q26ZxSzLAFF80JerefO-b0bYJS9eCLhRBMhDQVrRq2YEzSWSj2QptTKRlWesx-MHmjGdVbDnrHQW8frinXOw6azb63hwVTN4D75zpAmAUf9gKYz3zykHWxHqIF5_MMR7vk_7PiD8oynDI</recordid><startdate>20030321</startdate><enddate>20030321</enddate><creator>Brent Busby, M</creator><creator>Maldonado, Omar</creator><creator>Vigh, Gyula</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030321</creationdate><title>Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin as chiral resolving agent</title><author>Brent Busby, M ; Maldonado, Omar ; Vigh, Gyula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-da7b373d5665922650a150b45f22cd761495d0c0aee0ba47eca443bd771a18253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Cyclodextrins</topic><topic>Cyclodextrins - chemistry</topic><topic>Electrophoresis, Capillary - methods</topic><topic>gamma-Cyclodextrins</topic><topic>Hydrogen-Ion Concentration</topic><topic>Octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin</topic><topic>Stereoisomerism</topic><topic>Sulfated cyclodextrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brent Busby, M</creatorcontrib><creatorcontrib>Maldonado, Omar</creatorcontrib><creatorcontrib>Vigh, Gyula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brent Busby, M</au><au>Maldonado, Omar</au><au>Vigh, Gyula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin as chiral resolving agent</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2003-03-21</date><risdate>2003</risdate><volume>990</volume><issue>1</issue><spage>63</spage><epage>73</epage><pages>63-73</pages><issn>0021-9673</issn><abstract>The latest, single-isomer, sulfated γ-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6-
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| subjects | Cyclodextrins Cyclodextrins - chemistry Electrophoresis, Capillary - methods gamma-Cyclodextrins Hydrogen-Ion Concentration Octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin Stereoisomerism Sulfated cyclodextrins |
| title | Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6- O-sulfo)-γ-cyclodextrin as chiral resolving agent |
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