Use of extracorporeal life support in patients with congenital heart disease
OBJECTIVESTo review a large experience with extracorporeal life support in patients with congenital heart disease. To determine the major causes of mortality and morbidity in order to improve the results of using this technology in this patient population. DESIGNRetrospective chart review. PATIENTST...
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| Veröffentlicht in: | Critical care medicine 1992-09, Vol.20 (9), p.1216-1222 |
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| creator | DELIUS, RALPH E BOVE, EDWARD L MELIONES, JON N CUSTER, JOSEPH R MOLER, FRANK W CROWLEY, DENNIS AMIRIKIA, AREZO BEHRENDT, DOUGLAS M BARTLETT, ROBERT H |
| description | OBJECTIVESTo review a large experience with extracorporeal life support in patients with congenital heart disease. To determine the major causes of mortality and morbidity in order to improve the results of using this technology in this patient population.
DESIGNRetrospective chart review.
PATIENTSTwenty-five patients between the ages of 1 day and 8 yrs. These patients had congenital heart disease and were clinically felt to be at high risk for death caused by cardiac failure or by respiratory failure complicated by congenital heart disease.
INTERVENTIONSAll patients in this report were placed on extracorporeal life support to allow recovery of myocardial or pulmonary function.
MEASUREMENTS AND MAIN RESULTSOf these 25 patients, 52% were weaned from bypass support and 40% survived to discharge. Patients who were not weaned from extracorporeal life support characteristically suffered from irreversible neurologic injury, multiple organ failure, or bleeding complications. Only one patient died of irreversible cardiac failure.
CONCLUSIONSExtracorporeal life support can be useful in supporting patients with congenital heart disease with life-threatening cardiac or pulmonary failure. Improvements in limiting neurologic and bleeding complications may lead to improvements in the use of extracorporeal life support for this indication. However, prospective, randomized studies are needed to appreciate the role of extracorporeal life support in these patients. |
| doi_str_mv | 10.1097/00003246-199209000-00007 |
| format | Article |
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DESIGNRetrospective chart review.
PATIENTSTwenty-five patients between the ages of 1 day and 8 yrs. These patients had congenital heart disease and were clinically felt to be at high risk for death caused by cardiac failure or by respiratory failure complicated by congenital heart disease.
INTERVENTIONSAll patients in this report were placed on extracorporeal life support to allow recovery of myocardial or pulmonary function.
MEASUREMENTS AND MAIN RESULTSOf these 25 patients, 52% were weaned from bypass support and 40% survived to discharge. Patients who were not weaned from extracorporeal life support characteristically suffered from irreversible neurologic injury, multiple organ failure, or bleeding complications. Only one patient died of irreversible cardiac failure.
CONCLUSIONSExtracorporeal life support can be useful in supporting patients with congenital heart disease with life-threatening cardiac or pulmonary failure. Improvements in limiting neurologic and bleeding complications may lead to improvements in the use of extracorporeal life support for this indication. However, prospective, randomized studies are needed to appreciate the role of extracorporeal life support in these patients.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199209000-00007</identifier><identifier>PMID: 1521436</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Equipment Failure ; Extracorporeal Membrane Oxygenation - adverse effects ; Extracorporeal Membrane Oxygenation - instrumentation ; Extracorporeal Membrane Oxygenation - statistics & numerical data ; Female ; Heart Defects, Congenital - complications ; Heart Defects, Congenital - mortality ; Heart Defects, Congenital - therapy ; Hemorrhage - epidemiology ; Hemorrhage - etiology ; Humans ; Infant ; Infant, Newborn ; Intensive care medicine ; Life Support Care - methods ; Life Support Care - statistics & numerical data ; Life Support Systems - statistics & numerical data ; Male ; Medical sciences ; Michigan ; Nervous System Diseases - epidemiology ; Nervous System Diseases - etiology ; Retrospective Studies ; Technology Assessment, Biomedical ; Ventilator Weaning - mortality ; Ventilator Weaning - statistics & numerical data</subject><ispartof>Critical care medicine, 1992-09, Vol.20 (9), p.1216-1222</ispartof><rights>Williams & Wilkins 1992. All Rights Reserved.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-36d9e3926c642bfe1b7c34cec8eb8fd43b4b6e99fa6eda9fca6ed6e3eb2e93393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4310548$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1521436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DELIUS, RALPH E</creatorcontrib><creatorcontrib>BOVE, EDWARD L</creatorcontrib><creatorcontrib>MELIONES, JON N</creatorcontrib><creatorcontrib>CUSTER, JOSEPH R</creatorcontrib><creatorcontrib>MOLER, FRANK W</creatorcontrib><creatorcontrib>CROWLEY, DENNIS</creatorcontrib><creatorcontrib>AMIRIKIA, AREZO</creatorcontrib><creatorcontrib>BEHRENDT, DOUGLAS M</creatorcontrib><creatorcontrib>BARTLETT, ROBERT H</creatorcontrib><title>Use of extracorporeal life support in patients with congenital heart disease</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVESTo review a large experience with extracorporeal life support in patients with congenital heart disease. To determine the major causes of mortality and morbidity in order to improve the results of using this technology in this patient population.
DESIGNRetrospective chart review.
PATIENTSTwenty-five patients between the ages of 1 day and 8 yrs. These patients had congenital heart disease and were clinically felt to be at high risk for death caused by cardiac failure or by respiratory failure complicated by congenital heart disease.
INTERVENTIONSAll patients in this report were placed on extracorporeal life support to allow recovery of myocardial or pulmonary function.
MEASUREMENTS AND MAIN RESULTSOf these 25 patients, 52% were weaned from bypass support and 40% survived to discharge. Patients who were not weaned from extracorporeal life support characteristically suffered from irreversible neurologic injury, multiple organ failure, or bleeding complications. Only one patient died of irreversible cardiac failure.
CONCLUSIONSExtracorporeal life support can be useful in supporting patients with congenital heart disease with life-threatening cardiac or pulmonary failure. Improvements in limiting neurologic and bleeding complications may lead to improvements in the use of extracorporeal life support for this indication. However, prospective, randomized studies are needed to appreciate the role of extracorporeal life support in these patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Equipment Failure</subject><subject>Extracorporeal Membrane Oxygenation - adverse effects</subject><subject>Extracorporeal Membrane Oxygenation - instrumentation</subject><subject>Extracorporeal Membrane Oxygenation - statistics & numerical data</subject><subject>Female</subject><subject>Heart Defects, Congenital - complications</subject><subject>Heart Defects, Congenital - mortality</subject><subject>Heart Defects, Congenital - therapy</subject><subject>Hemorrhage - epidemiology</subject><subject>Hemorrhage - etiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Life Support Care - methods</subject><subject>Life Support Care - statistics & numerical data</subject><subject>Life Support Systems - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Michigan</subject><subject>Nervous System Diseases - epidemiology</subject><subject>Nervous System Diseases - etiology</subject><subject>Retrospective Studies</subject><subject>Technology Assessment, Biomedical</subject><subject>Ventilator Weaning - mortality</subject><subject>Ventilator Weaning - statistics & numerical data</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFvGyEQhVGVyHWS_oRKHKLetoUdzC7HKmraSpZ6Sc6IZYeYFO9ugZWTfx8cu84pcxm9ed-A9IYQytlXzlTzjZWCWsiKK1UzVVS1HzUfyJKvoIhawRlZsmJVIBR8JBcpPTLGxaqBBVnwVc0FyCVZ3yeko6P4lKOxY5zGiCbQ4B3SNE9FZuoHOpnscciJ7nzeUDsODzj4XMANmkL0PqFJeEXOnQkJPx37Jbm__XF386ta__n5--b7urLQiqYC2SsEVUsrRd055F1jQVi0LXat6wV0opOolDMSe6Oc3XeJgF2NCkDBJflyeHeK478ZU9ZbnyyGYAYc56Qb4C1Tcg-2B9DGMaWITk_Rb0181pzpfZD6f5D6FOTrqCmrn49_zN0W-7fFQ3LFvz76JlkTXDSD9emECeBsJdqCiQO2G0PGmP6GeYdRl9hC3uj3zggvChmL3w</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>DELIUS, RALPH E</creator><creator>BOVE, EDWARD L</creator><creator>MELIONES, JON N</creator><creator>CUSTER, JOSEPH R</creator><creator>MOLER, FRANK W</creator><creator>CROWLEY, DENNIS</creator><creator>AMIRIKIA, AREZO</creator><creator>BEHRENDT, DOUGLAS M</creator><creator>BARTLETT, ROBERT H</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199209</creationdate><title>Use of extracorporeal life support in patients with congenital heart disease</title><author>DELIUS, RALPH E ; BOVE, EDWARD L ; MELIONES, JON N ; CUSTER, JOSEPH R ; MOLER, FRANK W ; CROWLEY, DENNIS ; AMIRIKIA, AREZO ; BEHRENDT, DOUGLAS M ; BARTLETT, ROBERT H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-36d9e3926c642bfe1b7c34cec8eb8fd43b4b6e99fa6eda9fca6ed6e3eb2e93393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Equipment Failure</topic><topic>Extracorporeal Membrane Oxygenation - adverse effects</topic><topic>Extracorporeal Membrane Oxygenation - instrumentation</topic><topic>Extracorporeal Membrane Oxygenation - statistics & numerical data</topic><topic>Female</topic><topic>Heart Defects, Congenital - complications</topic><topic>Heart Defects, Congenital - mortality</topic><topic>Heart Defects, Congenital - therapy</topic><topic>Hemorrhage - epidemiology</topic><topic>Hemorrhage - etiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Life Support Care - methods</topic><topic>Life Support Care - statistics & numerical data</topic><topic>Life Support Systems - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Michigan</topic><topic>Nervous System Diseases - epidemiology</topic><topic>Nervous System Diseases - etiology</topic><topic>Retrospective Studies</topic><topic>Technology Assessment, Biomedical</topic><topic>Ventilator Weaning - mortality</topic><topic>Ventilator Weaning - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DELIUS, RALPH E</creatorcontrib><creatorcontrib>BOVE, EDWARD L</creatorcontrib><creatorcontrib>MELIONES, JON N</creatorcontrib><creatorcontrib>CUSTER, JOSEPH R</creatorcontrib><creatorcontrib>MOLER, FRANK W</creatorcontrib><creatorcontrib>CROWLEY, DENNIS</creatorcontrib><creatorcontrib>AMIRIKIA, AREZO</creatorcontrib><creatorcontrib>BEHRENDT, DOUGLAS M</creatorcontrib><creatorcontrib>BARTLETT, ROBERT H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DELIUS, RALPH E</au><au>BOVE, EDWARD L</au><au>MELIONES, JON N</au><au>CUSTER, JOSEPH R</au><au>MOLER, FRANK W</au><au>CROWLEY, DENNIS</au><au>AMIRIKIA, AREZO</au><au>BEHRENDT, DOUGLAS M</au><au>BARTLETT, ROBERT H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of extracorporeal life support in patients with congenital heart disease</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1992-09</date><risdate>1992</risdate><volume>20</volume><issue>9</issue><spage>1216</spage><epage>1222</epage><pages>1216-1222</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVESTo review a large experience with extracorporeal life support in patients with congenital heart disease. To determine the major causes of mortality and morbidity in order to improve the results of using this technology in this patient population.
DESIGNRetrospective chart review.
PATIENTSTwenty-five patients between the ages of 1 day and 8 yrs. These patients had congenital heart disease and were clinically felt to be at high risk for death caused by cardiac failure or by respiratory failure complicated by congenital heart disease.
INTERVENTIONSAll patients in this report were placed on extracorporeal life support to allow recovery of myocardial or pulmonary function.
MEASUREMENTS AND MAIN RESULTSOf these 25 patients, 52% were weaned from bypass support and 40% survived to discharge. Patients who were not weaned from extracorporeal life support characteristically suffered from irreversible neurologic injury, multiple organ failure, or bleeding complications. Only one patient died of irreversible cardiac failure.
CONCLUSIONSExtracorporeal life support can be useful in supporting patients with congenital heart disease with life-threatening cardiac or pulmonary failure. Improvements in limiting neurologic and bleeding complications may lead to improvements in the use of extracorporeal life support for this indication. However, prospective, randomized studies are needed to appreciate the role of extracorporeal life support in these patients.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>1521436</pmid><doi>10.1097/00003246-199209000-00007</doi><tpages>7</tpages></addata></record> |
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| ispartof | Critical care medicine, 1992-09, Vol.20 (9), p.1216-1222 |
| issn | 0090-3493 1530-0293 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Child Child, Preschool Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Equipment Failure Extracorporeal Membrane Oxygenation - adverse effects Extracorporeal Membrane Oxygenation - instrumentation Extracorporeal Membrane Oxygenation - statistics & numerical data Female Heart Defects, Congenital - complications Heart Defects, Congenital - mortality Heart Defects, Congenital - therapy Hemorrhage - epidemiology Hemorrhage - etiology Humans Infant Infant, Newborn Intensive care medicine Life Support Care - methods Life Support Care - statistics & numerical data Life Support Systems - statistics & numerical data Male Medical sciences Michigan Nervous System Diseases - epidemiology Nervous System Diseases - etiology Retrospective Studies Technology Assessment, Biomedical Ventilator Weaning - mortality Ventilator Weaning - statistics & numerical data |
| title | Use of extracorporeal life support in patients with congenital heart disease |
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