CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity
Soluble CD14 (sCD14), detectable at high concentrations constitutively present in the circulation, plays a key role in the neutralization of lipopolysaccharide, one of the most potent biologic response modifiers currently recognized and involved in the regulation of the inflammatory cascade. We test...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2003-04, Vol.88 (4), p.1780-1784 |
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| creator | Fernández-Real, José Manuel Broch, Montserrat Richart, Cristóbal Vendrell, Joan López-Bermejo, Abel Ricart, Wifredo |
| description | Soluble CD14 (sCD14), detectable at high concentrations constitutively present in the circulation, plays a key role in the neutralization of lipopolysaccharide, one of the most potent biologic response modifiers currently recognized and involved in the regulation of the inflammatory cascade. We tested whether circulating sCD14 was linked to inflammatory parameters and to insulin resistance in apparently healthy subjects.
Serum sCD14 concentration did not significantly correlate with body mass index (BMI), waist to hip ratio, systolic or diastolic blood pressure, serum glucose, fasting insulin, fasting insulin resistance index [homeostasis model assessment (HOMA)], or serum uric acid among 123 subjects. The association between sCD14 and fasting insulin (r = −0.19, P = 0.08) and between sCD14 and HOMA (r = −0.21, P = 0.06) tended toward statistical significance among men. Unexpectedly, sCD14 correlated positively with fasting triglycerides (TG) in all the subjects (r = 0.22, P = 0.014), and this association was most significant in men (r = 0.34, P = 0.002). After controlling for TG, the relationships between sCD14 levels and fasting insulin (r = −0.25, P = 0.029), HOMA (r = −0.28, P = 0.014), and uric acid (r = −0.30, P = 0.006) were significant in men. Among nonsmoking men (n = 44), sCD14 significantly correlated with waist diameter (r = −0.30, P = 0.03), diastolic blood pressure (r = −0.34, P = 0.022), and HOMA (r = −0.30, P = 0.03). In a multiple linear regression analysis, BMI (P < 0.00001), TG (P = 0.003), and sCD14 (P = 0.04) (but not age, sex, waist, or smoking status) independently contributed to 26% of HOMA variance.
A polymorphism of the CD14 gene, a C-to-T transition at bp −159 from the major transcription start site, seems to play a significant role in regulating serum sCD14 levels. In a subsample of 33 healthy subjects, carriers of the T allele were similar (in age, sex, BMI, fat mass, waist to hip ratio, blood pressure, and fasting glucose and insulin levels) to C/C homozygotes. In the former, integrated area under the curve for serum glucose concentrations after an oral glucose tolerance test was significantly lower (P = 0.02), and insulin sensitivity (SI) index (minimal model analysis) significantly higher (P = 0.036), than in C/C homozygotes. Among 32 type 2 diabetic subjects, carriers of the T allele also showed a significantly higher SI index (P = 0.03) and had significantly lower C-reactive protein (P = 0.03) and lower circulating soluble |
| doi_str_mv | 10.1210/jc.2002-020173 |
| format | Article |
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Serum sCD14 concentration did not significantly correlate with body mass index (BMI), waist to hip ratio, systolic or diastolic blood pressure, serum glucose, fasting insulin, fasting insulin resistance index [homeostasis model assessment (HOMA)], or serum uric acid among 123 subjects. The association between sCD14 and fasting insulin (r = −0.19, P = 0.08) and between sCD14 and HOMA (r = −0.21, P = 0.06) tended toward statistical significance among men. Unexpectedly, sCD14 correlated positively with fasting triglycerides (TG) in all the subjects (r = 0.22, P = 0.014), and this association was most significant in men (r = 0.34, P = 0.002). After controlling for TG, the relationships between sCD14 levels and fasting insulin (r = −0.25, P = 0.029), HOMA (r = −0.28, P = 0.014), and uric acid (r = −0.30, P = 0.006) were significant in men. Among nonsmoking men (n = 44), sCD14 significantly correlated with waist diameter (r = −0.30, P = 0.03), diastolic blood pressure (r = −0.34, P = 0.022), and HOMA (r = −0.30, P = 0.03). In a multiple linear regression analysis, BMI (P < 0.00001), TG (P = 0.003), and sCD14 (P = 0.04) (but not age, sex, waist, or smoking status) independently contributed to 26% of HOMA variance.
A polymorphism of the CD14 gene, a C-to-T transition at bp −159 from the major transcription start site, seems to play a significant role in regulating serum sCD14 levels. In a subsample of 33 healthy subjects, carriers of the T allele were similar (in age, sex, BMI, fat mass, waist to hip ratio, blood pressure, and fasting glucose and insulin levels) to C/C homozygotes. In the former, integrated area under the curve for serum glucose concentrations after an oral glucose tolerance test was significantly lower (P = 0.02), and insulin sensitivity (SI) index (minimal model analysis) significantly higher (P = 0.036), than in C/C homozygotes. Among 32 type 2 diabetic subjects, carriers of the T allele also showed a significantly higher SI index (P = 0.03) and had significantly lower C-reactive protein (P = 0.03) and lower circulating soluble intercellular adhesion molecule-1 concentrations (P = 0.01) than did C/C homozygotes.
To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2002-020173</identifier><identifier>PMID: 12679473</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Blood Pressure ; Body Constitution ; Body Mass Index ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - physiopathology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting ; Female ; Genotype ; Glucose Tolerance Test ; Homeostasis ; Humans ; Inflammation - physiopathology ; Insulin - blood ; Insulin Resistance ; Intercellular Adhesion Molecule-1 - blood ; Lipopolysaccharide Receptors - blood ; Lipopolysaccharide Receptors - genetics ; Lipopolysaccharide Receptors - physiology ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Sex Characteristics ; Smoking</subject><ispartof>The journal of clinical endocrinology and metabolism, 2003-04, Vol.88 (4), p.1780-1784</ispartof><rights>Copyright © 2003 by The Endocrine Society</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4527-c9ad00f67bb3c9ed69876749ac6adb75588bd40a6da3899a2a93a70955077fc73</citedby><cites>FETCH-LOGICAL-c4527-c9ad00f67bb3c9ed69876749ac6adb75588bd40a6da3899a2a93a70955077fc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14717198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12679473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Real, José Manuel</creatorcontrib><creatorcontrib>Broch, Montserrat</creatorcontrib><creatorcontrib>Richart, Cristóbal</creatorcontrib><creatorcontrib>Vendrell, Joan</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><title>CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Soluble CD14 (sCD14), detectable at high concentrations constitutively present in the circulation, plays a key role in the neutralization of lipopolysaccharide, one of the most potent biologic response modifiers currently recognized and involved in the regulation of the inflammatory cascade. We tested whether circulating sCD14 was linked to inflammatory parameters and to insulin resistance in apparently healthy subjects.
Serum sCD14 concentration did not significantly correlate with body mass index (BMI), waist to hip ratio, systolic or diastolic blood pressure, serum glucose, fasting insulin, fasting insulin resistance index [homeostasis model assessment (HOMA)], or serum uric acid among 123 subjects. The association between sCD14 and fasting insulin (r = −0.19, P = 0.08) and between sCD14 and HOMA (r = −0.21, P = 0.06) tended toward statistical significance among men. Unexpectedly, sCD14 correlated positively with fasting triglycerides (TG) in all the subjects (r = 0.22, P = 0.014), and this association was most significant in men (r = 0.34, P = 0.002). After controlling for TG, the relationships between sCD14 levels and fasting insulin (r = −0.25, P = 0.029), HOMA (r = −0.28, P = 0.014), and uric acid (r = −0.30, P = 0.006) were significant in men. Among nonsmoking men (n = 44), sCD14 significantly correlated with waist diameter (r = −0.30, P = 0.03), diastolic blood pressure (r = −0.34, P = 0.022), and HOMA (r = −0.30, P = 0.03). In a multiple linear regression analysis, BMI (P < 0.00001), TG (P = 0.003), and sCD14 (P = 0.04) (but not age, sex, waist, or smoking status) independently contributed to 26% of HOMA variance.
A polymorphism of the CD14 gene, a C-to-T transition at bp −159 from the major transcription start site, seems to play a significant role in regulating serum sCD14 levels. In a subsample of 33 healthy subjects, carriers of the T allele were similar (in age, sex, BMI, fat mass, waist to hip ratio, blood pressure, and fasting glucose and insulin levels) to C/C homozygotes. In the former, integrated area under the curve for serum glucose concentrations after an oral glucose tolerance test was significantly lower (P = 0.02), and insulin sensitivity (SI) index (minimal model analysis) significantly higher (P = 0.036), than in C/C homozygotes. Among 32 type 2 diabetic subjects, carriers of the T allele also showed a significantly higher SI index (P = 0.03) and had significantly lower C-reactive protein (P = 0.03) and lower circulating soluble intercellular adhesion molecule-1 concentrations (P = 0.01) than did C/C homozygotes.
To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure</subject><subject>Body Constitution</subject><subject>Body Mass Index</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fasting</subject><subject>Female</subject><subject>Genotype</subject><subject>Glucose Tolerance Test</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Inflammation - physiopathology</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Lipopolysaccharide Receptors - genetics</subject><subject>Lipopolysaccharide Receptors - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic</subject><subject>Sex Characteristics</subject><subject>Smoking</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUGL1DAUgIMo7rjr1aP0oqftmDRpX3OUcdWFFcF1wVtIk1emY5qMSTvL_PvN0IE9GQjh8b73XvKFkHeMrlnF6KedWVeUViWtKAP-gqyYFHUJTMJLssoJVkqo_lyQNyntKGVC1Pw1uWBVA1IAX5GHzRcmih_BB3OcsPiFBvdTiNfFrT8Ed0BbDL6Ytpjj3ulx1Dl5LDY6GW3xutDe5kyaXabu0adhGg7DdLwir3rtEr49n5fk4evN78338u7nt9vN57vSiLqC0khtKe0b6DpuJNpGttCAkNo02nZQ123bWUF1YzVvpdSVllwDlXVNAXoD_JJ8XPruY_g3Y5rUOCSDzmmPYU4KOGtpw0UG1wtoYkgpYq_2cRh1PCpG1Umk2hl1EqkWkbng_bnz3I1on_GzuQx8OAMnF66P2pshPXMCWP6FNnNi4R6DmzCmv25-xKi2qN20VTQv0UBb5tmcihyVedenl9VLGXobTBw87iOmpHZhjj4r_d-9nwA9yps6</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Fernández-Real, José Manuel</creator><creator>Broch, Montserrat</creator><creator>Richart, Cristóbal</creator><creator>Vendrell, Joan</creator><creator>López-Bermejo, Abel</creator><creator>Ricart, Wifredo</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity</title><author>Fernández-Real, José Manuel ; Broch, Montserrat ; Richart, Cristóbal ; Vendrell, Joan ; López-Bermejo, Abel ; Ricart, Wifredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4527-c9ad00f67bb3c9ed69876749ac6adb75588bd40a6da3899a2a93a70955077fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure</topic><topic>Body Constitution</topic><topic>Body Mass Index</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fasting</topic><topic>Female</topic><topic>Genotype</topic><topic>Glucose Tolerance Test</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Inflammation - physiopathology</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Lipopolysaccharide Receptors - blood</topic><topic>Lipopolysaccharide Receptors - genetics</topic><topic>Lipopolysaccharide Receptors - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic</topic><topic>Sex Characteristics</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Real, José Manuel</creatorcontrib><creatorcontrib>Broch, Montserrat</creatorcontrib><creatorcontrib>Richart, Cristóbal</creatorcontrib><creatorcontrib>Vendrell, Joan</creatorcontrib><creatorcontrib>López-Bermejo, Abel</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Real, José Manuel</au><au>Broch, Montserrat</au><au>Richart, Cristóbal</au><au>Vendrell, Joan</au><au>López-Bermejo, Abel</au><au>Ricart, Wifredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2003-04</date><risdate>2003</risdate><volume>88</volume><issue>4</issue><spage>1780</spage><epage>1784</epage><pages>1780-1784</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Soluble CD14 (sCD14), detectable at high concentrations constitutively present in the circulation, plays a key role in the neutralization of lipopolysaccharide, one of the most potent biologic response modifiers currently recognized and involved in the regulation of the inflammatory cascade. We tested whether circulating sCD14 was linked to inflammatory parameters and to insulin resistance in apparently healthy subjects.
Serum sCD14 concentration did not significantly correlate with body mass index (BMI), waist to hip ratio, systolic or diastolic blood pressure, serum glucose, fasting insulin, fasting insulin resistance index [homeostasis model assessment (HOMA)], or serum uric acid among 123 subjects. The association between sCD14 and fasting insulin (r = −0.19, P = 0.08) and between sCD14 and HOMA (r = −0.21, P = 0.06) tended toward statistical significance among men. Unexpectedly, sCD14 correlated positively with fasting triglycerides (TG) in all the subjects (r = 0.22, P = 0.014), and this association was most significant in men (r = 0.34, P = 0.002). After controlling for TG, the relationships between sCD14 levels and fasting insulin (r = −0.25, P = 0.029), HOMA (r = −0.28, P = 0.014), and uric acid (r = −0.30, P = 0.006) were significant in men. Among nonsmoking men (n = 44), sCD14 significantly correlated with waist diameter (r = −0.30, P = 0.03), diastolic blood pressure (r = −0.34, P = 0.022), and HOMA (r = −0.30, P = 0.03). In a multiple linear regression analysis, BMI (P < 0.00001), TG (P = 0.003), and sCD14 (P = 0.04) (but not age, sex, waist, or smoking status) independently contributed to 26% of HOMA variance.
A polymorphism of the CD14 gene, a C-to-T transition at bp −159 from the major transcription start site, seems to play a significant role in regulating serum sCD14 levels. In a subsample of 33 healthy subjects, carriers of the T allele were similar (in age, sex, BMI, fat mass, waist to hip ratio, blood pressure, and fasting glucose and insulin levels) to C/C homozygotes. In the former, integrated area under the curve for serum glucose concentrations after an oral glucose tolerance test was significantly lower (P = 0.02), and insulin sensitivity (SI) index (minimal model analysis) significantly higher (P = 0.036), than in C/C homozygotes. Among 32 type 2 diabetic subjects, carriers of the T allele also showed a significantly higher SI index (P = 0.03) and had significantly lower C-reactive protein (P = 0.03) and lower circulating soluble intercellular adhesion molecule-1 concentrations (P = 0.01) than did C/C homozygotes.
To our knowledge, this is the first study to suggest an effect of a genetic polymorphism on both SI (healthy subjects and type 2 diabetic patients) and endothelial dysfunction (sICAM-1 levels) in type 2 diabetes mellitus.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>12679473</pmid><doi>10.1210/jc.2002-020173</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological and medical sciences Blood Glucose - analysis Blood Pressure Body Constitution Body Mass Index Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - physiopathology Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Female Genotype Glucose Tolerance Test Homeostasis Humans Inflammation - physiopathology Insulin - blood Insulin Resistance Intercellular Adhesion Molecule-1 - blood Lipopolysaccharide Receptors - blood Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - physiology Male Medical sciences Middle Aged Polymorphism, Genetic Promoter Regions, Genetic Sex Characteristics Smoking |
| title | CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity |
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