Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells

A comparison was made between two K vitamin analogs. Growth in vitro of Hep G2 hepatoma cells was inhibited both by Compound 5 (Cpd 5), a recently synthesized thioalkyl analog of vitamin K or 2-(2-mercaptoethanol)-3-methyl-1, 4-naphthoquinone, as well as by synthetic vitamin K 3 (menadione). Using s...

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Veröffentlicht in:	Life sciences (1973) 2003-05, Vol.72 (24), p.2769-2784
Hauptverfasser:	Markovits, Judith, Wang, Ziqiu, Carr, Brian I, Sun, Te Ping, Mintz, Pierre, Le Bret, Marc, Wu, Cheng-Wen, Wu, Felicia Y.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Carcinoma, Hepatocellular - metabolism cdc25 Phosphatases - physiology Cell cycle Cell Cycle Proteins - metabolism Computer Simulation Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - metabolism G1 Phase - drug effects G2 Phase - drug effects Growth inhibition Humans Liver Neoplasms - metabolism Models, Molecular Precipitin Tests Protein phosphatase Proto-Oncogene Proteins S Phase - drug effects Tumor Cells, Cultured Vitamin K 1 - analogs & derivatives Vitamin K 1 - pharmacology Vitamin K 2 - analogs & derivatives Vitamin K 2 - pharmacology
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