Regional haemodynamic effects of urocortin in the anaesthetized rat

Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure...

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Veröffentlicht in:	European journal of pharmacology 2003-04, Vol.466 (3), p.317-321
Hauptverfasser:	Abdelrahman, Aly M, Pang, Catherine C.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Arterial conductance Arterial pressure Biological and medical sciences Blood flow Blood Pressure - drug effects Brain - blood supply Cardiac output Cardiac Output - drug effects Cecum - blood supply Colon - blood supply Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Heart Rate - drug effects Hemodynamics - drug effects Injections, Intravenous Kidney - blood supply Liver - blood supply Male Medical sciences Muscle, Skeletal - blood supply Neuroprotective Agents - pharmacology Peripheral resistance Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Skin - blood supply Spleen - blood supply Stomach - blood supply Urocortin Urocortins Vascular Resistance - drug effects
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