Regional haemodynamic effects of urocortin in the anaesthetized rat
Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure...
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| Veröffentlicht in: | European journal of pharmacology 2003-04, Vol.466 (3), p.317-321 |
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| creator | Abdelrahman, Aly M Pang, Catherine C.Y |
| description | Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (−25 mm Hg) through a decrease in total peripheral resistance (−43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes. |
| doi_str_mv | 10.1016/S0014-2999(03)01568-1 |
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We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (−25 mm Hg) through a decrease in total peripheral resistance (−43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. 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We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (−25 mm Hg) through a decrease in total peripheral resistance (−43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Arterial conductance</subject><subject>Arterial pressure</subject><subject>Biological and medical sciences</subject><subject>Blood flow</subject><subject>Blood Pressure - drug effects</subject><subject>Brain - blood supply</subject><subject>Cardiac output</subject><subject>Cardiac Output - drug effects</subject><subject>Cecum - blood supply</subject><subject>Colon - blood supply</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Injections, Intravenous</subject><subject>Kidney - blood supply</subject><subject>Liver - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Peripheral resistance</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional Blood Flow - drug effects</subject><subject>Skin - blood supply</subject><subject>Spleen - blood supply</subject><subject>Stomach - blood supply</subject><subject>Urocortin</subject><subject>Urocortins</subject><subject>Vascular Resistance - drug effects</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LJDEQQIOs6OzoT1D6ssvuod1U0ununGQZ1BUGBFfPIZNUnEh3R5MeQX-9GWdwjkJRVYdXHzxCToCeAYX6z39KoSqZlPIX5b8piLotYY9MoG1kSRtg38jkEzkk31N6pJQKycQBOQRWy6oFMSGzW3zwYdBdsdTYB_s66N6bAp1DM6YiuGIVgwlx9EORY1xioQeNKTejf0NbRD0ekX2nu4TH2zol95cXd7N_5fzm6nr2d14aLmEsAUSlpWSGcYe2bVyVk2yN5XVTgRbMUukqYReWy1YvHDcSLaM8UxxsveBT8nOz9ymG51X-QfU-Gew6PWBYJZWxlgoOGRQb0MSQUkSnnqLvdXxVQNXanvqwp9ZqFOXqw55az51uD6wWPdrd1FZXBn5sAZ2M7lzUg_Fpx1W1kC1rMne-4TDrePEYVTIeB4PWx-xV2eC_eOUdQ6aLuA</recordid><startdate>20030418</startdate><enddate>20030418</enddate><creator>Abdelrahman, Aly M</creator><creator>Pang, Catherine C.Y</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030418</creationdate><title>Regional haemodynamic effects of urocortin in the anaesthetized rat</title><author>Abdelrahman, Aly M ; Pang, Catherine C.Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-1154a992c23fed87f4d8798cd36741a52d09f45dbd398abf3c9ed203d8731d6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Arterial conductance</topic><topic>Arterial pressure</topic><topic>Biological and medical sciences</topic><topic>Blood flow</topic><topic>Blood Pressure - drug effects</topic><topic>Brain - blood supply</topic><topic>Cardiac output</topic><topic>Cardiac Output - drug effects</topic><topic>Cecum - blood supply</topic><topic>Colon - blood supply</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Injections, Intravenous</topic><topic>Kidney - blood supply</topic><topic>Liver - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Peripheral resistance</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional Blood Flow - drug effects</topic><topic>Skin - blood supply</topic><topic>Spleen - blood supply</topic><topic>Stomach - blood supply</topic><topic>Urocortin</topic><topic>Urocortins</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelrahman, Aly M</creatorcontrib><creatorcontrib>Pang, Catherine C.Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelrahman, Aly M</au><au>Pang, Catherine C.Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional haemodynamic effects of urocortin in the anaesthetized rat</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2003-04-18</date><risdate>2003</risdate><volume>466</volume><issue>3</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Urocortin is an endogenous vasodilator peptide that is related to corticotrophin-releasing factor. We examined the haemodynamic effects of urocortin in thiobutabarbital-anaesthetized rats, via the triple-isotope microspheres technique. Urocortin (3 nmol/kg, i.v. bolus) reduced mean arterial pressure (−25 mm Hg) through a decrease in total peripheral resistance (−43%). This was associated with an increase in cardiac output (+24%) and vasodilatation of the following tissues: heart and stomach (≈300% of baseline); liver, intestine, caecum/colon, skeletal muscle and skin (≈200%); and testes (≈150%). Arterial conductances of the kidneys, spleen and brain were unaffected by urocortin. Neither the vehicle (0.9% NaCl) nor a low dose of urocortin (0.3 nmol/kg) altered any measurements. Therefore, urocortin causes generalized vasodilatation as follows: heart and stomach>liver, intestine, caecum/colon, skeletal muscle and skin>testes.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12694815</pmid><doi>10.1016/S0014-2999(03)01568-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia Animals Arterial conductance Arterial pressure Biological and medical sciences Blood flow Blood Pressure - drug effects Brain - blood supply Cardiac output Cardiac Output - drug effects Cecum - blood supply Colon - blood supply Corticotropin-Releasing Hormone - pharmacology Dose-Response Relationship, Drug Heart Rate - drug effects Hemodynamics - drug effects Injections, Intravenous Kidney - blood supply Liver - blood supply Male Medical sciences Muscle, Skeletal - blood supply Neuroprotective Agents - pharmacology Peripheral resistance Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Skin - blood supply Spleen - blood supply Stomach - blood supply Urocortin Urocortins Vascular Resistance - drug effects |
| title | Regional haemodynamic effects of urocortin in the anaesthetized rat |
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