Homeostasis as Regulated by Activated Macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour
The effect of LPSw, a lipopolysaccharide from a water extract of wheat flour, on pain response was investigated using an acetic acid-induced writhing test in mice. LPSw inhibited writhing dose-dependently in the range of 10 ng-10 μg/mouse i.v. This effect reached its maximum 1.5-3 h after the LPSw i...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1992/04/25, Vol.40(4), pp.1001-1003 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | OKUTOMI, Takafumi NISHIZAWA, Takashi INAGAWA, Hiroyuki MORIKAWA, Akinobu TAKEUCHI, Shoshichi SOMA, Gen-Ichiro MIZUNO, Den'ichi |
| description | The effect of LPSw, a lipopolysaccharide from a water extract of wheat flour, on pain response was investigated using an acetic acid-induced writhing test in mice. LPSw inhibited writhing dose-dependently in the range of 10 ng-10 μg/mouse i.v. This effect reached its maximum 1.5-3 h after the LPSw inoculation and was detectable even after 8 h. The analgesic effect of LPSw was inhibited by i.v. injection of naloxone and also β-endorphin was detected in serum and brain tissue following injection of LPSw.Preliminary clinical trials were done in which LPSw was administered percutaneously to relieve the pain of patients with herpes. The results showed that pain was relieved by this application. LPSw may be the best analgesic drug so far known, since it induces the endogenous mediator of analgesia, β-endorphin. |
| doi_str_mv | 10.1248/cpb.40.1001 |
| format | Article |
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IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>OKUTOMI, Takafumi ; NISHIZAWA, Takashi ; INAGAWA, Hiroyuki ; MORIKAWA, Akinobu ; TAKEUCHI, Shoshichi ; SOMA, Gen-Ichiro ; MIZUNO, Den'ichi</creator><creatorcontrib>OKUTOMI, Takafumi ; NISHIZAWA, Takashi ; INAGAWA, Hiroyuki ; MORIKAWA, Akinobu ; TAKEUCHI, Shoshichi ; SOMA, Gen-Ichiro ; MIZUNO, Den'ichi</creatorcontrib><description>The effect of LPSw, a lipopolysaccharide from a water extract of wheat flour, on pain response was investigated using an acetic acid-induced writhing test in mice. LPSw inhibited writhing dose-dependently in the range of 10 ng-10 μg/mouse i.v. This effect reached its maximum 1.5-3 h after the LPSw inoculation and was detectable even after 8 h. The analgesic effect of LPSw was inhibited by i.v. injection of naloxone and also β-endorphin was detected in serum and brain tissue following injection of LPSw.Preliminary clinical trials were done in which LPSw was administered percutaneously to relieve the pain of patients with herpes. The results showed that pain was relieved by this application. LPSw may be the best analgesic drug so far known, since it induces the endogenous mediator of analgesia, β-endorphin.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.40.1001</identifier><identifier>PMID: 1525927</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>analgesic effect ; Analgesics - pharmacology ; Animals ; clinical trial ; Flour ; herpes ; Homeostasis - physiology ; Humans ; lipopolysaccharide ; Lipopolysaccharides - administration & dosage ; Macrophage Activation - drug effects ; Macrophage Activation - physiology ; Male ; Mice ; Mice, Inbred C3H ; Triticum ; β-endorphin</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1992/04/25, Vol.40(4), pp.1001-1003</ispartof><rights>The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5191-8988aa09a669658ba8c3e57eed3a5170a64efc7164c404a6b90f5a0be4c686db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1525927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OKUTOMI, Takafumi</creatorcontrib><creatorcontrib>NISHIZAWA, Takashi</creatorcontrib><creatorcontrib>INAGAWA, Hiroyuki</creatorcontrib><creatorcontrib>MORIKAWA, Akinobu</creatorcontrib><creatorcontrib>TAKEUCHI, Shoshichi</creatorcontrib><creatorcontrib>SOMA, Gen-Ichiro</creatorcontrib><creatorcontrib>MIZUNO, Den'ichi</creatorcontrib><title>Homeostasis as Regulated by Activated Macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The effect of LPSw, a lipopolysaccharide from a water extract of wheat flour, on pain response was investigated using an acetic acid-induced writhing test in mice. LPSw inhibited writhing dose-dependently in the range of 10 ng-10 μg/mouse i.v. This effect reached its maximum 1.5-3 h after the LPSw inoculation and was detectable even after 8 h. The analgesic effect of LPSw was inhibited by i.v. injection of naloxone and also β-endorphin was detected in serum and brain tissue following injection of LPSw.Preliminary clinical trials were done in which LPSw was administered percutaneously to relieve the pain of patients with herpes. The results showed that pain was relieved by this application. LPSw may be the best analgesic drug so far known, since it induces the endogenous mediator of analgesia, β-endorphin.</description><subject>analgesic effect</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>clinical trial</subject><subject>Flour</subject><subject>herpes</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophage Activation - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Triticum</subject><subject>β-endorphin</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtu2zAQRYmiReK4XXUdgKtuErmk-BC5NPIGXLRo0nYpjKiRrUA2FVFK4L8PFRnNZmaIc3EBHkK-crbgqTTfXVssZLwZ4x_IjAuZJSpNxUcyY4zZJBVaHJOTEB4ZSxXLxBE54ipVNs1mJNz6LfrQQ6gDhUB_43pooMeSFnu6dH39_Pb4Aa7z7QbWuKB3fxd0uYNmjaF29Kqq0PXUV3T16_7lnAJd1a1vfbMP4NwGurrEkf7bIPT0uvFD95l8qqAJ-OWw5-TP9dXDxW2y-nlzd7FcJU5xyxNjjQFgFrS2WpkCjBOoMsRSgOIZAy2xchnX0kkmQReWVQpYgdJpo8tCzMm3qbft_NOAoc-3dXDYNLBDP4Q8EzyzxtoYPJuC8ZMhdFjlbVdvodvnnOWj4jwqzmW8o-KYPj3UDsUWy_fs5DTyy4k_Rq1r_M-h62vX4NjFrTJjn5zGWPuOo7Mcd-IVNtGOlA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>OKUTOMI, Takafumi</creator><creator>NISHIZAWA, Takashi</creator><creator>INAGAWA, Hiroyuki</creator><creator>MORIKAWA, Akinobu</creator><creator>TAKEUCHI, Shoshichi</creator><creator>SOMA, Gen-Ichiro</creator><creator>MIZUNO, Den'ichi</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Homeostasis as Regulated by Activated Macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour</title><author>OKUTOMI, Takafumi ; NISHIZAWA, Takashi ; INAGAWA, Hiroyuki ; MORIKAWA, Akinobu ; TAKEUCHI, Shoshichi ; SOMA, Gen-Ichiro ; MIZUNO, Den'ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5191-8988aa09a669658ba8c3e57eed3a5170a64efc7164c404a6b90f5a0be4c686db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>analgesic effect</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>clinical trial</topic><topic>Flour</topic><topic>herpes</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophage Activation - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Triticum</topic><topic>β-endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OKUTOMI, Takafumi</creatorcontrib><creatorcontrib>NISHIZAWA, Takashi</creatorcontrib><creatorcontrib>INAGAWA, Hiroyuki</creatorcontrib><creatorcontrib>MORIKAWA, Akinobu</creatorcontrib><creatorcontrib>TAKEUCHI, Shoshichi</creatorcontrib><creatorcontrib>SOMA, Gen-Ichiro</creatorcontrib><creatorcontrib>MIZUNO, Den'ichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OKUTOMI, Takafumi</au><au>NISHIZAWA, Takashi</au><au>INAGAWA, Hiroyuki</au><au>MORIKAWA, Akinobu</au><au>TAKEUCHI, Shoshichi</au><au>SOMA, Gen-Ichiro</au><au>MIZUNO, Den'ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homeostasis as Regulated by Activated Macrophage. 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The results showed that pain was relieved by this application. LPSw may be the best analgesic drug so far known, since it induces the endogenous mediator of analgesia, β-endorphin.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1525927</pmid><doi>10.1248/cpb.40.1001</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1992/04/25, Vol.40(4), pp.1001-1003 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | analgesic effect Analgesics - pharmacology Animals clinical trial Flour herpes Homeostasis - physiology Humans lipopolysaccharide Lipopolysaccharides - administration & dosage Macrophage Activation - drug effects Macrophage Activation - physiology Male Mice Mice, Inbred C3H Triticum β-endorphin |
| title | Homeostasis as Regulated by Activated Macrophage. IV. Analgesic Effect of LPSw, a Lipopolysaccharide of Wheat Flour |
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