Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos
Evidence that the larval stage of Echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in Alaska. The efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by m...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 1992-08, Vol.15 (2), p.234-249 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 2 |
| container_start_page | 234 |
| container_title | Clinical infectious diseases |
| container_volume | 15 |
| creator | Wilson, J. F. Rausch, R. L. McMahon, B. J. Schantz, P. M. |
| description | Evidence that the larval stage of Echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in Alaska. The efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by means of inoculation of voles, immunohistochemical tests, and histopathologic findings. Of 14 tests performed for nine patients, 12 in vivo assays (86%) were negative after chemotherapy, while only two (17%) of 12 vole tests for seven untreated patients were negative. Regression or arrest of growth of metastatic and primary hepatic lesions, together with their partial-to-complete calcification and prolonged survival times has been observed among patients treated with the benzimidazole compounds. For six who received appropriate chemotherapy, treatment has been discontinued for an average of 4.6 years (range, 3–7 years) without an increase in lesion size or other evidence of reactivation. |
| doi_str_mv | 10.1093/clinids/15.2.234 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_73179357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4456584</jstor_id><sourcerecordid>4456584</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-f2285ef3c63d76b0eb07ecf3ee9f79bae94af3dac1de06f33a0259e53bc076493</originalsourceid><addsrcrecordid>eNpFkE1v00AQhi0EKqVw5wDSnrg53fV4vTa3kgSCVARCICEuq_HurLKNP9Jdp236E_qrcXDUnmZGz7zv4UmSt4LPBK_g3DS-8zaeCznLZhnkz5JTIUGlhazE83HnskzzEsqXyasYrzgXouTyJDkRMuNKlqfJww8MGP3gjbfYsKVzZAbWOzZfU9sPawq43TPfsYvmhvoGA1vtLQ7esoWPhJE-sp904-n2kFnebSl46gyxWz-s2TeqqbN43zfEsLNjx9P9vxLjBju2jBvf9vF18sJhE-nNcZ4lvz8vf81X6eX3L1_nF5epAQlD6rKslOTAFGBVUXOquSLjgKhyqqqRqhwdWDTCEi8cAPJMViShNlwVeQVnyYepdxv66x3FQbc-Gmoa7KjfRa1AqAqkGh_59GhCH2Mgp7fBtxj2WnB90K-P-rWQOtOj_jHy_ti9q1uyT4HJ98jfTfwqDn14xHkuC1ke4umEfRzo7hFj2OhCgZJ69eev_iRlvlgI0Bz-AajpnWQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73179357</pqid></control><display><type>article</type><title>Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Wilson, J. F. ; Rausch, R. L. ; McMahon, B. J. ; Schantz, P. M.</creator><creatorcontrib>Wilson, J. F. ; Rausch, R. L. ; McMahon, B. J. ; Schantz, P. M.</creatorcontrib><description>Evidence that the larval stage of Echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in Alaska. The efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by means of inoculation of voles, immunohistochemical tests, and histopathologic findings. Of 14 tests performed for nine patients, 12 in vivo assays (86%) were negative after chemotherapy, while only two (17%) of 12 vole tests for seven untreated patients were negative. Regression or arrest of growth of metastatic and primary hepatic lesions, together with their partial-to-complete calcification and prolonged survival times has been observed among patients treated with the benzimidazole compounds. For six who received appropriate chemotherapy, treatment has been discontinued for an average of 4.6 years (range, 3–7 years) without an increase in lesion size or other evidence of reactivation.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/15.2.234</identifier><identifier>PMID: 1520758</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alaska ; Albendazole - therapeutic use ; Autopsies ; Biopsies ; Chemotherapy ; Clinical Infectious Disease Articles ; Echinococcosis - drug therapy ; Echinococcosis - pathology ; Follow-Up Studies ; Humans ; Hydatids ; Inuits ; Larvae ; Lesions ; Liver ; Mebendazole - therapeutic use ; Middle Aged ; Parasitic diseases ; Viability ; Voles</subject><ispartof>Clinical infectious diseases, 1992-08, Vol.15 (2), p.234-249</ispartof><rights>Copyright 1992 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-f2285ef3c63d76b0eb07ecf3ee9f79bae94af3dac1de06f33a0259e53bc076493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4456584$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4456584$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1520758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, J. F.</creatorcontrib><creatorcontrib>Rausch, R. L.</creatorcontrib><creatorcontrib>McMahon, B. J.</creatorcontrib><creatorcontrib>Schantz, P. M.</creatorcontrib><title>Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Evidence that the larval stage of Echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in Alaska. The efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by means of inoculation of voles, immunohistochemical tests, and histopathologic findings. Of 14 tests performed for nine patients, 12 in vivo assays (86%) were negative after chemotherapy, while only two (17%) of 12 vole tests for seven untreated patients were negative. Regression or arrest of growth of metastatic and primary hepatic lesions, together with their partial-to-complete calcification and prolonged survival times has been observed among patients treated with the benzimidazole compounds. For six who received appropriate chemotherapy, treatment has been discontinued for an average of 4.6 years (range, 3–7 years) without an increase in lesion size or other evidence of reactivation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alaska</subject><subject>Albendazole - therapeutic use</subject><subject>Autopsies</subject><subject>Biopsies</subject><subject>Chemotherapy</subject><subject>Clinical Infectious Disease Articles</subject><subject>Echinococcosis - drug therapy</subject><subject>Echinococcosis - pathology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydatids</subject><subject>Inuits</subject><subject>Larvae</subject><subject>Lesions</subject><subject>Liver</subject><subject>Mebendazole - therapeutic use</subject><subject>Middle Aged</subject><subject>Parasitic diseases</subject><subject>Viability</subject><subject>Voles</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v00AQhi0EKqVw5wDSnrg53fV4vTa3kgSCVARCICEuq_HurLKNP9Jdp236E_qrcXDUnmZGz7zv4UmSt4LPBK_g3DS-8zaeCznLZhnkz5JTIUGlhazE83HnskzzEsqXyasYrzgXouTyJDkRMuNKlqfJww8MGP3gjbfYsKVzZAbWOzZfU9sPawq43TPfsYvmhvoGA1vtLQ7esoWPhJE-sp904-n2kFnebSl46gyxWz-s2TeqqbN43zfEsLNjx9P9vxLjBju2jBvf9vF18sJhE-nNcZ4lvz8vf81X6eX3L1_nF5epAQlD6rKslOTAFGBVUXOquSLjgKhyqqqRqhwdWDTCEi8cAPJMViShNlwVeQVnyYepdxv66x3FQbc-Gmoa7KjfRa1AqAqkGh_59GhCH2Mgp7fBtxj2WnB90K-P-rWQOtOj_jHy_ti9q1uyT4HJ98jfTfwqDn14xHkuC1ke4umEfRzo7hFj2OhCgZJ69eev_iRlvlgI0Bz-AajpnWQ</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Wilson, J. F.</creator><creator>Rausch, R. L.</creator><creator>McMahon, B. J.</creator><creator>Schantz, P. M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos</title><author>Wilson, J. F. ; Rausch, R. L. ; McMahon, B. J. ; Schantz, P. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-f2285ef3c63d76b0eb07ecf3ee9f79bae94af3dac1de06f33a0259e53bc076493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alaska</topic><topic>Albendazole - therapeutic use</topic><topic>Autopsies</topic><topic>Biopsies</topic><topic>Chemotherapy</topic><topic>Clinical Infectious Disease Articles</topic><topic>Echinococcosis - drug therapy</topic><topic>Echinococcosis - pathology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hydatids</topic><topic>Inuits</topic><topic>Larvae</topic><topic>Lesions</topic><topic>Liver</topic><topic>Mebendazole - therapeutic use</topic><topic>Middle Aged</topic><topic>Parasitic diseases</topic><topic>Viability</topic><topic>Voles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, J. F.</creatorcontrib><creatorcontrib>Rausch, R. L.</creatorcontrib><creatorcontrib>McMahon, B. J.</creatorcontrib><creatorcontrib>Schantz, P. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, J. F.</au><au>Rausch, R. L.</au><au>McMahon, B. J.</au><au>Schantz, P. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>15</volume><issue>2</issue><spage>234</spage><epage>249</epage><pages>234-249</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Evidence that the larval stage of Echinococcus multilocularis in humans is killed by chemotherapy is presented in a review of our 17-year experience with treatment of alveolar hydatid disease in Alaska. The efficacy of chemotherapy was assessed with use of an in vivo assay of parasite viability by means of inoculation of voles, immunohistochemical tests, and histopathologic findings. Of 14 tests performed for nine patients, 12 in vivo assays (86%) were negative after chemotherapy, while only two (17%) of 12 vole tests for seven untreated patients were negative. Regression or arrest of growth of metastatic and primary hepatic lesions, together with their partial-to-complete calcification and prolonged survival times has been observed among patients treated with the benzimidazole compounds. For six who received appropriate chemotherapy, treatment has been discontinued for an average of 4.6 years (range, 3–7 years) without an increase in lesion size or other evidence of reactivation.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>1520758</pmid><doi>10.1093/clinids/15.2.234</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 1992-08, Vol.15 (2), p.234-249 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73179357 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; JSTOR Archive Collection A-Z Listing |
| subjects | Adult Aged Aged, 80 and over Alaska Albendazole - therapeutic use Autopsies Biopsies Chemotherapy Clinical Infectious Disease Articles Echinococcosis - drug therapy Echinococcosis - pathology Follow-Up Studies Humans Hydatids Inuits Larvae Lesions Liver Mebendazole - therapeutic use Middle Aged Parasitic diseases Viability Voles |
| title | Parasiticidal Effect of Chemotherapy in Alveolar Hydatid Disease: Review of Experience with Mebendazole and Albendazole in Alaskan Eskimos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T23%3A11%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parasiticidal%20Effect%20of%20Chemotherapy%20in%20Alveolar%20Hydatid%20Disease:%20Review%20of%20Experience%20with%20Mebendazole%20and%20Albendazole%20in%20Alaskan%20Eskimos&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Wilson,%20J.%20F.&rft.date=1992-08-01&rft.volume=15&rft.issue=2&rft.spage=234&rft.epage=249&rft.pages=234-249&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/clinids/15.2.234&rft_dat=%3Cjstor_proqu%3E4456584%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73179357&rft_id=info:pmid/1520758&rft_jstor_id=4456584&rfr_iscdi=true |