The antitumor potency of progesterone antagonists is due to their differentiation potential

A new therapy for the progesterone receptor positive mammary carcinoma may be the treatment with progesterone antagonists. This new class of antihormones causes a strong inhibition of tumor growth comparable to the potency of ovariectomy in a panel of experimental mammary carcinomas. The mechanisms...

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Veröffentlicht in:	Journal of steroid biochemistry and molecular biology 1992-09, Vol.43 (1), p.203-210
Hauptverfasser:	Michna, Horst, Gehring, Svante, Kühnel, Wolfgang, Nishino, Yukishige, Schneider, Martin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Cell Differentiation - drug effects General aspects Gonanes - therapeutic use Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mifepristone - analogs & derivatives Mifepristone - therapeutic use Pharmacology. Drug treatments Progesterone - antagonists & inhibitors Rats
Online-Zugang:	Volltext
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