A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6-month period
Background. Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect an...
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| Veröffentlicht in: | Head & neck 2003-05, Vol.25 (5), p.361-367 |
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| creator | Jones, Andrew Simpson Young, Pamela Elizabeth Hanafi, Zul Bin Makura, Zorustra George Grange Fenton, John Elian Hughes, Joseph Peter |
| description | Background.
Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect and in particular whether raised tissue oxygenation is maintained using a practical filter device.
Methods.
We carried out a 6‐month randomized control trial including 50 laryngectomees. Twenty‐five patients were treated with the Liverpool Heat Moisture Exchange device incorporating an airway resistor (Trachinaze). Another 25 patients were treated with a placebo device. Relevant subjective and objective data were collected before and at the end of the study. The objective measurements were capillary oxygen tension (which parallels blood arterial tension), carbon dioxide tension, FEV1, FVC, and PIF. Patients were reviewed at intervals throughout the study. Data were analyzed using the Mann–Whitney U test and the paired t test to test the difference between the active device and placebo at 6 months.
Results.
Subjective lower airway parameters, including cough, number of chest infections, mucus production, and shortness of breath at rest, were significantly improved in the active group compared with the placebo group. The objective parameters FEV1, FVC, and PIF were not significantly different. Capillary oxygen tension, however, was highly significantly raised in the active group at 6 months.
Conclusions.
Trachinaze is highly superior to placebo at improving subjective pulmonary parameters, including shortness of breath. It is also superior in its ability to maintain an increased peripheral tissue oxygen tension over a 6‐month period. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003 |
| doi_str_mv | 10.1002/hed.10264 |
| format | Article |
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Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect and in particular whether raised tissue oxygenation is maintained using a practical filter device.
Methods.
We carried out a 6‐month randomized control trial including 50 laryngectomees. Twenty‐five patients were treated with the Liverpool Heat Moisture Exchange device incorporating an airway resistor (Trachinaze). Another 25 patients were treated with a placebo device. Relevant subjective and objective data were collected before and at the end of the study. The objective measurements were capillary oxygen tension (which parallels blood arterial tension), carbon dioxide tension, FEV1, FVC, and PIF. Patients were reviewed at intervals throughout the study. Data were analyzed using the Mann–Whitney U test and the paired t test to test the difference between the active device and placebo at 6 months.
Results.
Subjective lower airway parameters, including cough, number of chest infections, mucus production, and shortness of breath at rest, were significantly improved in the active group compared with the placebo group. The objective parameters FEV1, FVC, and PIF were not significantly different. Capillary oxygen tension, however, was highly significantly raised in the active group at 6 months.
Conclusions.
Trachinaze is highly superior to placebo at improving subjective pulmonary parameters, including shortness of breath. It is also superior in its ability to maintain an increased peripheral tissue oxygen tension over a 6‐month period. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.10264</identifier><identifier>PMID: 12692872</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Airway Resistance ; Biological and medical sciences ; blood gases ; cancer of the larynx ; cancer of the larynx, blood gases ; Carbon Dioxide - blood ; Female ; Filtration - instrumentation ; Forced Expiratory Volume ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Hot Temperature ; Humans ; Humidity ; Inspiratory Capacity ; Laryngectomy - rehabilitation ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Oxygen - blood ; pulmonary function ; pulmonary resistive loading hypoxaemia ; Respiratory Mechanics ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the upper aerodigestive tract ; tracheostomy ; Tracheostomy - instrumentation ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vital Capacity</subject><ispartof>Head & neck, 2003-05, Vol.25 (5), p.361-367</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4554-cf9ce7d5ea55c39e06bd815ab2b4c2949a2c124a52e813055b4679377011ecf73</citedby><cites>FETCH-LOGICAL-c4554-cf9ce7d5ea55c39e06bd815ab2b4c2949a2c124a52e813055b4679377011ecf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.10264$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.10264$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14707842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12692872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Andrew Simpson</creatorcontrib><creatorcontrib>Young, Pamela Elizabeth</creatorcontrib><creatorcontrib>Hanafi, Zul Bin</creatorcontrib><creatorcontrib>Makura, Zorustra George Grange</creatorcontrib><creatorcontrib>Fenton, John Elian</creatorcontrib><creatorcontrib>Hughes, Joseph Peter</creatorcontrib><title>A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6-month period</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect and in particular whether raised tissue oxygenation is maintained using a practical filter device.
Methods.
We carried out a 6‐month randomized control trial including 50 laryngectomees. Twenty‐five patients were treated with the Liverpool Heat Moisture Exchange device incorporating an airway resistor (Trachinaze). Another 25 patients were treated with a placebo device. Relevant subjective and objective data were collected before and at the end of the study. The objective measurements were capillary oxygen tension (which parallels blood arterial tension), carbon dioxide tension, FEV1, FVC, and PIF. Patients were reviewed at intervals throughout the study. Data were analyzed using the Mann–Whitney U test and the paired t test to test the difference between the active device and placebo at 6 months.
Results.
Subjective lower airway parameters, including cough, number of chest infections, mucus production, and shortness of breath at rest, were significantly improved in the active group compared with the placebo group. The objective parameters FEV1, FVC, and PIF were not significantly different. Capillary oxygen tension, however, was highly significantly raised in the active group at 6 months.
Conclusions.
Trachinaze is highly superior to placebo at improving subjective pulmonary parameters, including shortness of breath. It is also superior in its ability to maintain an increased peripheral tissue oxygen tension over a 6‐month period. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003</description><subject>Airway Resistance</subject><subject>Biological and medical sciences</subject><subject>blood gases</subject><subject>cancer of the larynx</subject><subject>cancer of the larynx, blood gases</subject><subject>Carbon Dioxide - blood</subject><subject>Female</subject><subject>Filtration - instrumentation</subject><subject>Forced Expiratory Volume</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Humidity</subject><subject>Inspiratory Capacity</subject><subject>Laryngectomy - rehabilitation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Oxygen - blood</subject><subject>pulmonary function</subject><subject>pulmonary resistive loading hypoxaemia</subject><subject>Respiratory Mechanics</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the upper aerodigestive tract</subject><subject>tracheostomy</subject><subject>Tracheostomy - instrumentation</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vital Capacity</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks9u1DAQxiMEon_gwAuguYDoIdRJ7DjhtlpKi7SCSxFSL5bjTDaGxN7aTtvtO_cdcNilPXHyzOjn75vxOEneZORjRkh-2mMbg7ykz5LDjNQ8JQXlz-eYFmlBOD1Ijrz_RQgpSpq_TA6yvKzziueHycMCfJjaLdgOQo-AXYcqzJkEh177oG8QepQBRhuzyUXmTvXSrNHBh-Ck6rWR93gC1sBmGkZrpNtCNxkVdCxJ00IzWNvCWnoIaHysetARlkGjCR5uewu9jDaTadGtrcFoPkSV6KGCHbefYAEuCtlR32MLyprg7ADBaTnMrTLyJDZPoyNkb2J_Eso0NhR62KDTtn2VvOjk4PH1_jxOfnw5u1xepKvv51-Xi1WqKGM0VV2tkLcMJWOqqJGUTVtlTDZ5Q1Ve01rmKsupZDlWWUEYa2jJ64JzkmWoOl4cJ-93uhtnryf0QYzaKxwGadBOXvAi4xWlVQRPdqBy1nuHndg4PcbRRUbEvFsRdyv-7jayb_eiUzPG6iO5X2YE3u0B6ZUcuvhkSvsnjnISXWfudMfd6gG3_3cUF2ef_1mnuxvxB-Dd4w3pfouSF5yJn9_OBStX1eXyiomr4g_7Bc5q</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Jones, Andrew Simpson</creator><creator>Young, Pamela Elizabeth</creator><creator>Hanafi, Zul Bin</creator><creator>Makura, Zorustra George Grange</creator><creator>Fenton, John Elian</creator><creator>Hughes, Joseph Peter</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200305</creationdate><title>A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6-month period</title><author>Jones, Andrew Simpson ; Young, Pamela Elizabeth ; Hanafi, Zul Bin ; Makura, Zorustra George Grange ; Fenton, John Elian ; Hughes, Joseph Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4554-cf9ce7d5ea55c39e06bd815ab2b4c2949a2c124a52e813055b4679377011ecf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Airway Resistance</topic><topic>Biological and medical sciences</topic><topic>blood gases</topic><topic>cancer of the larynx</topic><topic>cancer of the larynx, blood gases</topic><topic>Carbon Dioxide - blood</topic><topic>Female</topic><topic>Filtration - instrumentation</topic><topic>Forced Expiratory Volume</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Humidity</topic><topic>Inspiratory Capacity</topic><topic>Laryngectomy - rehabilitation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Oxygen - blood</topic><topic>pulmonary function</topic><topic>pulmonary resistive loading hypoxaemia</topic><topic>Respiratory Mechanics</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the upper aerodigestive tract</topic><topic>tracheostomy</topic><topic>Tracheostomy - instrumentation</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Andrew Simpson</creatorcontrib><creatorcontrib>Young, Pamela Elizabeth</creatorcontrib><creatorcontrib>Hanafi, Zul Bin</creatorcontrib><creatorcontrib>Makura, Zorustra George Grange</creatorcontrib><creatorcontrib>Fenton, John Elian</creatorcontrib><creatorcontrib>Hughes, Joseph Peter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Andrew Simpson</au><au>Young, Pamela Elizabeth</au><au>Hanafi, Zul Bin</au><au>Makura, Zorustra George Grange</au><au>Fenton, John Elian</au><au>Hughes, Joseph Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6-month period</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2003-05</date><risdate>2003</risdate><volume>25</volume><issue>5</issue><spage>361</spage><epage>367</epage><pages>361-367</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Previous work from this department has shown that resistive tracheostomy filters increase the partial pressure of oxygen in capillary blood and also provide a significant amount of heat/moisture exchange. Until now it has not been shown whether there is any long‐term beneficial effect and in particular whether raised tissue oxygenation is maintained using a practical filter device.
Methods.
We carried out a 6‐month randomized control trial including 50 laryngectomees. Twenty‐five patients were treated with the Liverpool Heat Moisture Exchange device incorporating an airway resistor (Trachinaze). Another 25 patients were treated with a placebo device. Relevant subjective and objective data were collected before and at the end of the study. The objective measurements were capillary oxygen tension (which parallels blood arterial tension), carbon dioxide tension, FEV1, FVC, and PIF. Patients were reviewed at intervals throughout the study. Data were analyzed using the Mann–Whitney U test and the paired t test to test the difference between the active device and placebo at 6 months.
Results.
Subjective lower airway parameters, including cough, number of chest infections, mucus production, and shortness of breath at rest, were significantly improved in the active group compared with the placebo group. The objective parameters FEV1, FVC, and PIF were not significantly different. Capillary oxygen tension, however, was highly significantly raised in the active group at 6 months.
Conclusions.
Trachinaze is highly superior to placebo at improving subjective pulmonary parameters, including shortness of breath. It is also superior in its ability to maintain an increased peripheral tissue oxygen tension over a 6‐month period. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12692872</pmid><doi>10.1002/hed.10264</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Airway Resistance Biological and medical sciences blood gases cancer of the larynx cancer of the larynx, blood gases Carbon Dioxide - blood Female Filtration - instrumentation Forced Expiratory Volume Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Hot Temperature Humans Humidity Inspiratory Capacity Laryngectomy - rehabilitation Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Oxygen - blood pulmonary function pulmonary resistive loading hypoxaemia Respiratory Mechanics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the upper aerodigestive tract tracheostomy Tracheostomy - instrumentation Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vital Capacity |
| title | A study of the effect of a resistive heat moisture exchanger (trachinaze) on pulmonary function and blood gas tensions in patients who have undergone a laryngectomy: A randomized control trial of 50 patients studied over a 6-month period |
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