Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2

A series of 11-[2-(1-benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxep in-2- carboxylic acid derivatives and related compounds were synthesized and found to be potent TXA2/PGH2 receptor antagonists. Each compound synthesized was tested for its ability to displace [3H]U-46619 binding from guinea...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-09, Vol.35 (18), p.3402-3413
Hauptverfasser:	Ohshima, Etsuo, Takami, Hitoshi, Sato, Hideyuki, Mohri, Shinichiro, Obase, Hiroyuki, Miki, Ichiro, Ishii, Akio, Shirakura, Shiro, Karasawa, Akira, Kubo, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Guinea Pigs Humans Male Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Receptors, Prostaglandin - antagonists & inhibitors Receptors, Thromboxane Structure-Activity Relationship Thromboxane A2 - metabolism
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