Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial
There is a lack of controlled trials examining the effectiveness of electroconvulsive therapy (ECT) combined with olanzapine or risperidone in treatment-resistant schizophrenia (TRS). The authors conducted a prospective, open, controlled trial of ECT in TRS in a long-term psychiatric rehabilitation...
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Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2003-05, Vol.27 (3), p.373-379 |
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description | There is a lack of controlled trials examining the effectiveness of electroconvulsive therapy (ECT) combined with olanzapine or risperidone in treatment-resistant schizophrenia (TRS). The authors conducted a prospective, open, controlled trial of ECT in TRS in a long-term psychiatric rehabilitation unit in Hong Kong. Thirty patients with TRS from an inpatient psychiatric rehabilitation unit participated in this study. All subjects were resistant to a host of antipsychotic medications given singly or in different combinations. In addition, they were also resistant to or they refused clozapine treatment. Fifteen patients completed a course of ECT consisting of 8–20 sessions. Fifteen patients who refused ECT formed the control Subjects were assessed at baseline, 1 week, 1 month, and 2 months after their last ECT. Assessment instruments included the Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Rating Scale (HDRS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment Scale (GAS), Clinical Global Impression (CGI), CGI Severity of Illness [CGI(SOI)], CGI Global Improvement [CGI(GI)], Nurses' Observation Scale for Inpatient Evaluation (NOSIE-30), and occupational therapists' rating of the subjects' functioning with respect to work (OT-W), social (OT-S), and leisure (OT-L) activities. In comparison with the control group, the ECT group showed statistically significant improvement only in the GAS and CGI at each posttreatment evaluation. There was a trend for ECT to reduce positive and negative symptoms, although the rate of improvement did not reach statistically significant levels. ECT augmentation of risperidone and olanzapine is of marginal efficacy compared to reports of the greater augmentation of these antipsychotics with other agents. |
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The authors conducted a prospective, open, controlled trial of ECT in TRS in a long-term psychiatric rehabilitation unit in Hong Kong. Thirty patients with TRS from an inpatient psychiatric rehabilitation unit participated in this study. All subjects were resistant to a host of antipsychotic medications given singly or in different combinations. In addition, they were also resistant to or they refused clozapine treatment. Fifteen patients completed a course of ECT consisting of 8–20 sessions. Fifteen patients who refused ECT formed the control Subjects were assessed at baseline, 1 week, 1 month, and 2 months after their last ECT. Assessment instruments included the Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Rating Scale (HDRS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment Scale (GAS), Clinical Global Impression (CGI), CGI Severity of Illness [CGI(SOI)], CGI Global Improvement [CGI(GI)], Nurses' Observation Scale for Inpatient Evaluation (NOSIE-30), and occupational therapists' rating of the subjects' functioning with respect to work (OT-W), social (OT-S), and leisure (OT-L) activities. In comparison with the control group, the ECT group showed statistically significant improvement only in the GAS and CGI at each posttreatment evaluation. There was a trend for ECT to reduce positive and negative symptoms, although the rate of improvement did not reach statistically significant levels. ECT augmentation of risperidone and olanzapine is of marginal efficacy compared to reports of the greater augmentation of these antipsychotics with other agents.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/S0278-5846(02)00354-8</identifier><identifier>PMID: 12691772</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; Clozapine ; Clozapine - therapeutic use ; Drug Therapy, Combination ; Electroconvulsive therapy ; Electroconvulsive Therapy - methods ; Electroconvulsive Therapy - statistics & numerical data ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Psychiatric Status Rating Scales - statistics & numerical data ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenia - therapy ; Schizophrenic Psychology ; Statistics, Nonparametric ; Treatment resistance ; Treatments</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2003-05, Vol.27 (3), p.373-379</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-b9a833169c7729b01d6eb107cd5f3ec9e74cd5514ca4cbd8d4c50eb8b9f075423</citedby><cites>FETCH-LOGICAL-c391t-b9a833169c7729b01d6eb107cd5f3ec9e74cd5514ca4cbd8d4c50eb8b9f075423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0278-5846(02)00354-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14672331$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12691772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Wai-Kwong</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><title>Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>There is a lack of controlled trials examining the effectiveness of electroconvulsive therapy (ECT) combined with olanzapine or risperidone in treatment-resistant schizophrenia (TRS). The authors conducted a prospective, open, controlled trial of ECT in TRS in a long-term psychiatric rehabilitation unit in Hong Kong. Thirty patients with TRS from an inpatient psychiatric rehabilitation unit participated in this study. All subjects were resistant to a host of antipsychotic medications given singly or in different combinations. In addition, they were also resistant to or they refused clozapine treatment. Fifteen patients completed a course of ECT consisting of 8–20 sessions. Fifteen patients who refused ECT formed the control Subjects were assessed at baseline, 1 week, 1 month, and 2 months after their last ECT. Assessment instruments included the Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Rating Scale (HDRS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment Scale (GAS), Clinical Global Impression (CGI), CGI Severity of Illness [CGI(SOI)], CGI Global Improvement [CGI(GI)], Nurses' Observation Scale for Inpatient Evaluation (NOSIE-30), and occupational therapists' rating of the subjects' functioning with respect to work (OT-W), social (OT-S), and leisure (OT-L) activities. In comparison with the control group, the ECT group showed statistically significant improvement only in the GAS and CGI at each posttreatment evaluation. There was a trend for ECT to reduce positive and negative symptoms, although the rate of improvement did not reach statistically significant levels. ECT augmentation of risperidone and olanzapine is of marginal efficacy compared to reports of the greater augmentation of these antipsychotics with other agents.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Clozapine</subject><subject>Clozapine - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Electroconvulsive therapy</subject><subject>Electroconvulsive Therapy - methods</subject><subject>Electroconvulsive Therapy - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Schizophrenia</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - therapy</subject><subject>Schizophrenic Psychology</subject><subject>Statistics, Nonparametric</subject><subject>Treatment resistance</subject><subject>Treatments</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP6zAQRi10EZTHT-Aqm4tgERjHzsNsEKp4SUgsgLXlTCaqUZrk2m6l8utxaQVLVras842_OYydcLjgwIvLF8jKKs0rWZxBdg4gcplWO2zCq_gsM178YZNvZJ8deP8OAFyA2GP7PCsUL8tswprbtrVocJUMbUIdYXADDv1y0Xm7pCTMyJlxldg-CY5MmFMfUkfe-mD6kHic2Y9hnDnqrblKTDK6wY9xyDo7jLROWdMdsd3WdJ6Ot-che7u7fZ0-pE_P94_Tm6cUheIhrZWphOCFwlhN1cCbgmoOJTZ5KwgVlTJecy7RSKybqpGYA9VVrVooc5mJQ3a6mRtr_F-QD3puPVLXmZ6GhdeliEuDUhHMNyDGvt5Rq0dn58atNAe91qu_9Oq1Ow2Z_tKrq5j7u_1gUc-p-UltfUbg3xYwHk3XOtOj9T-cLCIkeOSuNxxFHUtLTnu01CM11kV9uhnsL1U-AXXNmVo</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Tang, Wai-Kwong</creator><creator>Ungvari, Gabor S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial</title><author>Tang, Wai-Kwong ; Ungvari, Gabor S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-b9a833169c7729b01d6eb107cd5f3ec9e74cd5514ca4cbd8d4c50eb8b9f075423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Clozapine</topic><topic>Clozapine - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Electroconvulsive therapy</topic><topic>Electroconvulsive Therapy - methods</topic><topic>Electroconvulsive Therapy - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Schizophrenia</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - therapy</topic><topic>Schizophrenic Psychology</topic><topic>Statistics, Nonparametric</topic><topic>Treatment resistance</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Wai-Kwong</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Wai-Kwong</au><au>Ungvari, Gabor S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>27</volume><issue>3</issue><spage>373</spage><epage>379</epage><pages>373-379</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>There is a lack of controlled trials examining the effectiveness of electroconvulsive therapy (ECT) combined with olanzapine or risperidone in treatment-resistant schizophrenia (TRS). The authors conducted a prospective, open, controlled trial of ECT in TRS in a long-term psychiatric rehabilitation unit in Hong Kong. Thirty patients with TRS from an inpatient psychiatric rehabilitation unit participated in this study. All subjects were resistant to a host of antipsychotic medications given singly or in different combinations. In addition, they were also resistant to or they refused clozapine treatment. Fifteen patients completed a course of ECT consisting of 8–20 sessions. Fifteen patients who refused ECT formed the control Subjects were assessed at baseline, 1 week, 1 month, and 2 months after their last ECT. Assessment instruments included the Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Rating Scale (HDRS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment Scale (GAS), Clinical Global Impression (CGI), CGI Severity of Illness [CGI(SOI)], CGI Global Improvement [CGI(GI)], Nurses' Observation Scale for Inpatient Evaluation (NOSIE-30), and occupational therapists' rating of the subjects' functioning with respect to work (OT-W), social (OT-S), and leisure (OT-L) activities. In comparison with the control group, the ECT group showed statistically significant improvement only in the GAS and CGI at each posttreatment evaluation. There was a trend for ECT to reduce positive and negative symptoms, although the rate of improvement did not reach statistically significant levels. ECT augmentation of risperidone and olanzapine is of marginal efficacy compared to reports of the greater augmentation of these antipsychotics with other agents.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12691772</pmid><doi>10.1016/S0278-5846(02)00354-8</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Analysis of Variance Biological and medical sciences Clozapine Clozapine - therapeutic use Drug Therapy, Combination Electroconvulsive therapy Electroconvulsive Therapy - methods Electroconvulsive Therapy - statistics & numerical data Female Humans Male Medical sciences Middle Aged Prospective Studies Psychiatric Status Rating Scales - statistics & numerical data Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Schizophrenia Schizophrenia - drug therapy Schizophrenia - therapy Schizophrenic Psychology Statistics, Nonparametric Treatment resistance Treatments |
title | Efficacy of electroconvulsive therapy in treatment-resistant schizophrenia: a prospective open trial |
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