The effect of the kappa-opioid receptor agonist CI-977 in a rat model of focal cerebral ischaemia

The effect of a novel, highly potent and selective kappa-opioid receptor agonist CI-977 upon ischaemic brain damage and brain swelling has been examined in a rat model of focal cerebral ischaemia. Focal ischaemia was produced by the permanent occlusion of the left middle cerebral artery (MCA) during...

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Veröffentlicht in:	Brain research 1992-03, Vol.576 (1), p.147-151
Hauptverfasser:	Kusumoto, Kazuhiro, Mackay, Kenneth B., McCulloch, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzofurans - pharmacology Brain Edema - prevention & control Cerebral Infarction - prevention & control CI-977 Disease Models, Animal Edema Focal ischemia Infarction Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Kappa agonist Male Neuroprotection Pyrrolidines - pharmacology Rats Rats, Inbred Strains Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Opioid, kappa
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