Vascular endothelial growth factor inhibits outward delayed-rectifier potassium currents in acutely isolated hippocampal neurons

In the present study, whole-cell patch-clamp recording was used to study whether vascular endothelial growth factor (VEGF) had a regulatory effect on the potassium-channel currents. The outward delayed-rectifier potassium currents (I(K)) were recorded in acutely isolated hippocampal neurons from 14-...

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Veröffentlicht in:	Neuroscience 2003-04, Vol.118 (1), p.59-67
Hauptverfasser:	XU, J. Y, ZHENG, P, SHEN, D. H, YANG, S. Z, ZHANG, L. M, HUANG, Y. L, SUN, F.-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Central nervous system Dose-Response Relationship, Drug Electrophysiology Endothelial Growth Factors - metabolism Endothelial Growth Factors - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Immunohistochemistry Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Lymphokines - metabolism Lymphokines - pharmacology Male Microscopy, Confocal Neural Inhibition - drug effects Neural Inhibition - physiology Neurons - drug effects Neurons - metabolism Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 - drug effects Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - drug effects Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Endothelial Growth Factors Vertebrates: nervous system and sense organs
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