Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium

Epidermal growth factor (EGF) and receptor (‐R) signaling pathway is required for epithelial cell growth and differentiation such as the degeneration of the medial edge epithelial cells during the fusion process of secondary palate formation. As epithelial fusion takes place during primary palate fo...

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Veröffentlicht in:	Anatomical Science International 2003-03, Vol.78 (1), p.25-35
Hauptverfasser:	Fujino, Masako, Osumi, Noriko, Ninomiya, Youichirou, Iseki, Sachiko, Shibasaki, Yoshinobu, Eto, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - drug effects Body Patterning - physiology Cell culture Cell differentiation Cell Differentiation - drug effects Cell Differentiation - physiology Cell fusion Cytology Degeneration Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryo, Mammalian - ultrastructure Embryos Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology epidermal growth factor receptor Epithelial cells Epithelium Female Fetus Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Immunohistochemistry Immunoreactivity Male Mice Mice, Inbred C57BL Microscopy, Electron, Scanning mouse embryo Nasal Cavity - embryology Nasal Cavity - metabolism Nasal Cavity - ultrastructure Nasal Mucosa - embryology Nasal Mucosa - metabolism Nasal Mucosa - ultrastructure Organ Culture Techniques Palate Palate - embryology Palate - metabolism Palate - ultrastructure Pregnancy Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Signal transduction whole embryo culture
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