Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers
OBJECTIVETo determine the relationship between iv infusion rate, plasma concentrations, and hemodynamic and metabolic actions of norepinephrine. DESIGNNorepinephrine was administered by using five iv infusion rates (0.01 to 0.2 μg/kg/min) for 30 mins each to eight volunteers, for the purpose of cons...
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| Veröffentlicht in: | Critical care medicine 1992-09, Vol.20 (9), p.1250-1256 |
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| creator | ENSINGER, HERMANN STEIN, BERNHARD JÄGER, OLIVER GRÜNERT, ADOLF AHNEFELD, FRIEDRICH W |
| description | OBJECTIVETo determine the relationship between iv infusion rate, plasma concentrations, and hemodynamic and metabolic actions of norepinephrine.
DESIGNNorepinephrine was administered by using five iv infusion rates (0.01 to 0.2 μg/kg/min) for 30 mins each to eight volunteers, for the purpose of constructing cumulative plasma concentration-response curves.
SETTINGLaboratory of the Department of Anesthesiology at a university hospital.
MEASUREMENTS AND MAIN RESULTSSystolic and diastolic BP, heart rate, and the plasma concentrations of norepinephrine, glucose, non-esterified fatty acids, and insulin were measured at the end of each infusion rate. During the highest infusion rate, plasma norepinephrine concentrations increased from 199 ± 75 to 7475 ± 1071 pg/mL (1.18 ± 0.44 to 44.18 ± 6.33 nmol/L). Typical hemodynamic responses, such as increases in BP and decreases in heart rate, were seen, while the plasma concentrations of glucose and nonesterified fatty acids increased from 92 ± 10 to 132 ± 17 mg/dL (5.1 ± 0.6 to 7.3 ± 0.9 mmol/L) and 11 ± 4 to 34 ± 6 mg/dL (0.11 ± 0.04 to 0.34 ± 0.06 g/L), respectively, during the 0.2 μg/kg/min infusion rate (p |
| doi_str_mv | 10.1097/00003246-199209000-00011 |
| format | Article |
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DESIGNNorepinephrine was administered by using five iv infusion rates (0.01 to 0.2 μg/kg/min) for 30 mins each to eight volunteers, for the purpose of constructing cumulative plasma concentration-response curves.
SETTINGLaboratory of the Department of Anesthesiology at a university hospital.
MEASUREMENTS AND MAIN RESULTSSystolic and diastolic BP, heart rate, and the plasma concentrations of norepinephrine, glucose, non-esterified fatty acids, and insulin were measured at the end of each infusion rate. During the highest infusion rate, plasma norepinephrine concentrations increased from 199 ± 75 to 7475 ± 1071 pg/mL (1.18 ± 0.44 to 44.18 ± 6.33 nmol/L). Typical hemodynamic responses, such as increases in BP and decreases in heart rate, were seen, while the plasma concentrations of glucose and nonesterified fatty acids increased from 92 ± 10 to 132 ± 17 mg/dL (5.1 ± 0.6 to 7.3 ± 0.9 mmol/L) and 11 ± 4 to 34 ± 6 mg/dL (0.11 ± 0.04 to 0.34 ± 0.06 g/L), respectively, during the 0.2 μg/kg/min infusion rate (p <.05). Despite the increase in glucose concentration, insulin remained at baseline values. Metabolic and hemodynamic effects occurred at similar plasma concentrations throughout the study.
CONCLUSIONSAdministration of norepinephrine showed no selective hemodynamic actions. The metabolic responses observed in this investigation were similar to those responses seen during increased endogenous sympathetic nervous system activity, such as stress, exercise, or trauma.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199209000-00011</identifier><identifier>PMID: 1521439</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; Blood - drug effects ; Blood - metabolism ; Cardiotonic agents ; Cardiovascular system ; Cardiovascular System - drug effects ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Hemodynamics - drug effects ; Humans ; Infusions, Intravenous - methods ; Male ; Medical sciences ; Norepinephrine - administration & dosage ; Norepinephrine - blood ; Norepinephrine - pharmacology ; Pharmacology. Drug treatments ; Reference Values ; Regression Analysis ; Time Factors</subject><ispartof>Critical care medicine, 1992-09, Vol.20 (9), p.1250-1256</ispartof><rights>Williams & Wilkins 1992. All Rights Reserved.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4791-35a55d89c86ff5bc7ec07dbd51436a48fe9ed8ab48a6ffb6a9e84f4b9480cfb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4310552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1521439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ENSINGER, HERMANN</creatorcontrib><creatorcontrib>STEIN, BERNHARD</creatorcontrib><creatorcontrib>JÄGER, OLIVER</creatorcontrib><creatorcontrib>GRÜNERT, ADOLF</creatorcontrib><creatorcontrib>AHNEFELD, FRIEDRICH W</creatorcontrib><title>Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVETo determine the relationship between iv infusion rate, plasma concentrations, and hemodynamic and metabolic actions of norepinephrine.
DESIGNNorepinephrine was administered by using five iv infusion rates (0.01 to 0.2 μg/kg/min) for 30 mins each to eight volunteers, for the purpose of constructing cumulative plasma concentration-response curves.
SETTINGLaboratory of the Department of Anesthesiology at a university hospital.
MEASUREMENTS AND MAIN RESULTSSystolic and diastolic BP, heart rate, and the plasma concentrations of norepinephrine, glucose, non-esterified fatty acids, and insulin were measured at the end of each infusion rate. During the highest infusion rate, plasma norepinephrine concentrations increased from 199 ± 75 to 7475 ± 1071 pg/mL (1.18 ± 0.44 to 44.18 ± 6.33 nmol/L). Typical hemodynamic responses, such as increases in BP and decreases in heart rate, were seen, while the plasma concentrations of glucose and nonesterified fatty acids increased from 92 ± 10 to 132 ± 17 mg/dL (5.1 ± 0.6 to 7.3 ± 0.9 mmol/L) and 11 ± 4 to 34 ± 6 mg/dL (0.11 ± 0.04 to 0.34 ± 0.06 g/L), respectively, during the 0.2 μg/kg/min infusion rate (p <.05). Despite the increase in glucose concentration, insulin remained at baseline values. Metabolic and hemodynamic effects occurred at similar plasma concentrations throughout the study.
CONCLUSIONSAdministration of norepinephrine showed no selective hemodynamic actions. The metabolic responses observed in this investigation were similar to those responses seen during increased endogenous sympathetic nervous system activity, such as stress, exercise, or trauma.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood - drug effects</subject><subject>Blood - metabolism</subject><subject>Cardiotonic agents</subject><subject>Cardiovascular system</subject><subject>Cardiovascular System - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Infusions, Intravenous - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Norepinephrine - administration & dosage</subject><subject>Norepinephrine - blood</subject><subject>Norepinephrine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Time Factors</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kt9uFSEQxonR1GP1EUy4MF51dVng7HJpGv8lTUxM78ksO7goB1Zge9K38VGl3WN7JQkhM99vhjAfhFDWvmOt6t-3dfFO7BumVNeqGjV1M_aE7JjkNegUf0p2bZUaLhR_Tl7k_LMSQvb8jJwx2THB1Y78-Y4eioshz26hI5YjYqAu2DXXJE1QMF_QxUM-ADUxGAwlbQUXFMJEDaTJxRvIZvWQ7lMHLDBG7wxFa9GUTKc1ufCDlhkfW0dLQ0y4uIDLXOU7ic4Ivsy39Cb6NRTElF-SZxZ8xlen85xcf_p4ffmlufr2-evlh6vGiF6xhkuQchqUGfbWytH0aNp-GidZn7kHMVhUOA0wigEqMO5B4SCsGJUYWmNHfk7ebm2XFH-vmIs-uGzQewgY16x7znqueF_BYQNNijkntHpJ7gDpVrNW33mj_3mjH7zR997U0tenO9bxgNNj4WZG1d-c9DpN8DZBMC4_YIKzVsquYmLDjtGXOqFffj1i0tvo9P9-Bv8L7OCr0g</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>ENSINGER, HERMANN</creator><creator>STEIN, BERNHARD</creator><creator>JÄGER, OLIVER</creator><creator>GRÜNERT, ADOLF</creator><creator>AHNEFELD, FRIEDRICH W</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199209</creationdate><title>Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers</title><author>ENSINGER, HERMANN ; STEIN, BERNHARD ; JÄGER, OLIVER ; GRÜNERT, ADOLF ; AHNEFELD, FRIEDRICH W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4791-35a55d89c86ff5bc7ec07dbd51436a48fe9ed8ab48a6ffb6a9e84f4b9480cfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood - drug effects</topic><topic>Blood - metabolism</topic><topic>Cardiotonic agents</topic><topic>Cardiovascular system</topic><topic>Cardiovascular System - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Infusions, Intravenous - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Norepinephrine - administration & dosage</topic><topic>Norepinephrine - blood</topic><topic>Norepinephrine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ENSINGER, HERMANN</creatorcontrib><creatorcontrib>STEIN, BERNHARD</creatorcontrib><creatorcontrib>JÄGER, OLIVER</creatorcontrib><creatorcontrib>GRÜNERT, ADOLF</creatorcontrib><creatorcontrib>AHNEFELD, FRIEDRICH W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ENSINGER, HERMANN</au><au>STEIN, BERNHARD</au><au>JÄGER, OLIVER</au><au>GRÜNERT, ADOLF</au><au>AHNEFELD, FRIEDRICH W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1992-09</date><risdate>1992</risdate><volume>20</volume><issue>9</issue><spage>1250</spage><epage>1256</epage><pages>1250-1256</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVETo determine the relationship between iv infusion rate, plasma concentrations, and hemodynamic and metabolic actions of norepinephrine.
DESIGNNorepinephrine was administered by using five iv infusion rates (0.01 to 0.2 μg/kg/min) for 30 mins each to eight volunteers, for the purpose of constructing cumulative plasma concentration-response curves.
SETTINGLaboratory of the Department of Anesthesiology at a university hospital.
MEASUREMENTS AND MAIN RESULTSSystolic and diastolic BP, heart rate, and the plasma concentrations of norepinephrine, glucose, non-esterified fatty acids, and insulin were measured at the end of each infusion rate. During the highest infusion rate, plasma norepinephrine concentrations increased from 199 ± 75 to 7475 ± 1071 pg/mL (1.18 ± 0.44 to 44.18 ± 6.33 nmol/L). Typical hemodynamic responses, such as increases in BP and decreases in heart rate, were seen, while the plasma concentrations of glucose and nonesterified fatty acids increased from 92 ± 10 to 132 ± 17 mg/dL (5.1 ± 0.6 to 7.3 ± 0.9 mmol/L) and 11 ± 4 to 34 ± 6 mg/dL (0.11 ± 0.04 to 0.34 ± 0.06 g/L), respectively, during the 0.2 μg/kg/min infusion rate (p <.05). Despite the increase in glucose concentration, insulin remained at baseline values. Metabolic and hemodynamic effects occurred at similar plasma concentrations throughout the study.
CONCLUSIONSAdministration of norepinephrine showed no selective hemodynamic actions. The metabolic responses observed in this investigation were similar to those responses seen during increased endogenous sympathetic nervous system activity, such as stress, exercise, or trauma.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>1521439</pmid><doi>10.1097/00003246-199209000-00011</doi><tpages>7</tpages></addata></record> |
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| ispartof | Critical care medicine, 1992-09, Vol.20 (9), p.1250-1256 |
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| subjects | Adult Analysis of Variance Biological and medical sciences Blood - drug effects Blood - metabolism Cardiotonic agents Cardiovascular system Cardiovascular System - drug effects Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Hemodynamics - drug effects Humans Infusions, Intravenous - methods Male Medical sciences Norepinephrine - administration & dosage Norepinephrine - blood Norepinephrine - pharmacology Pharmacology. Drug treatments Reference Values Regression Analysis Time Factors |
| title | Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers |
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