Peroral TAS-202 reduced vessel density in rats with adjuvant-induced arthritis

The present study was designed to investigate blood vessel density interpreted as an indirect measurement of angiogenesis following 4-(3,4,5-trimethoxyphenyl)-6-(2,4,5-trimethoxyphenyl)-2-diethylamino-pyrimidine (TAS-202) treatment in a rat model of arthritis. Male Lewis rats were inoculated intrade...

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Veröffentlicht in:	European journal of pharmacology 2003-04, Vol.466 (1), p.191-197
Hauptverfasser:	Tanaka, Katsunao, Watanabe, Motomu, Kuraishi, Yasushi, Kimura, Ikuko, Suzuki, Takashi, Kiniwa, Mamoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant-induced arthritis Administration, Oral Angiogenesis inhibitor Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - microbiology Biological and medical sciences Blood Vessels - drug effects Blood Vessels - physiology Depression, Chemical Drug Therapy, Combination Indomethacin - pharmacology Indomethacin - therapeutic use Male Medical sciences Mycobacterium Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - immunology Neovascularization, Pathologic - microbiology Prednisone - pharmacology Prednisone - therapeutic use Pyrimidines - administration & dosage Pyrimidines - pharmacology Pyrimidines - therapeutic use Rats Rats, Inbred Lew Synovial Membrane - blood supply Synovial Membrane - drug effects TAS-202
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