Monoclonal antibody-.beta.-lactamase conjugates for the activation of a cephalosporin mustard prodrug

Cephalosporin mustard (CM) was designed as an anticancer prodrug that could be activated in a site-specific manner by monoclonal antibody-beta-lactamase conjugates targeted to antigens present on tumor cell surfaces. Purified beta-lactamases from Bacillus cereus (BC beta L) and Escherichia coli (EC...

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Veröffentlicht in:	Bioconjugate chemistry 1992-03, Vol.3 (2), p.176-181
Hauptverfasser:	Svensson, Hakan P, Kadow, John F, Vrudhula, Vivekananda M, Wallace, Philip M, Senter, Peter D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Bacillus cereus - enzymology beta-Lactamases - chemistry beta-Lactamases - metabolism Biological and medical sciences Biotechnology Biotransformation Cell Survival - drug effects Cephalosporins - chemistry Cephalosporins - metabolism Chromatography, High Pressure Liquid Escherichia coli - enzymology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Nitrogen Mustard Compounds - chemistry Nitrogen Mustard Compounds - metabolism Nitrogen Mustard Compounds - pharmacology Prodrugs - chemistry Prodrugs - metabolism Tumor Cells, Cultured
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