Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Amyloid-β peptide (Aβ) has a key role in the pathogenesis of Alzheimer disease (AD). Immunization with Aβ in a transgenic mouse model of AD reduces both age-related accumulation of Aβ in the brain 1 and associated cognitive impairment 2 , 3 . Here we present the first analysis of human neuropatholog...

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Veröffentlicht in:	Nature medicine 2003-04, Vol.9 (4), p.448-452
Hauptverfasser:	Nicoll, James A.R., Wilkinson, David, Holmes, Clive, Steart, Phil, Markham, Hannah, Weller, Roy O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - pathology Alzheimer Disease - therapy Alzheimer Vaccines - therapeutic use Amyloid beta-Peptides - immunology Biomedical and Life Sciences Biomedicine Brain - pathology Cancer Research Female Humans Infectious Diseases Meningoencephalitis - etiology Metabolic Diseases Molecular Medicine Neurosciences Peptide Fragments - immunology
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