Infection of human astrocytoma cells with simian-human immunodeficiency virus results in up-regulation of gene expression and altered growth properties

Recent reports of human immunodeficiency virus-1 (HIV-1) infection of astrocytes suggest a role for astrocytes in HIV encephalitis. In this study, we infected a human astrocytoma cell line with a pathogenic simian HIV (SHIV 50OLNV) and examined growth patterns and immunomodulatory genes. Approximate...

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Veröffentlicht in:	Neuroscience letters 2003-04, Vol.340 (3), p.201-204
Hauptverfasser:	Singh, Dinesh K., Chouduri, Rajani, Pacyniak, Erik, Berman, Nancy E.J., Stephens, Edward B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte activation Astrocyte infection Astrocytoma - genetics Astrocytoma - metabolism Astrocytoma - virology Biological and medical sciences Experimental viral diseases and models Gene array Gene Expression Regulation, Viral - physiology Glial Fibrillary Acidic Protein - biosynthesis Glial Fibrillary Acidic Protein - genetics HIV-1 - genetics HIV-1 - physiology Humans Infectious diseases Medical sciences NeuroAIDS Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - physiology Simian-human immunodeficiency virus Up-Regulation - genetics Up-Regulation - physiology Viral diseases
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