Phenylpropanoid Glycosides from Rhodiola rosea
Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1...
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| Veröffentlicht in: | Chemical & Pharmaceutical Bulletin 2003, Vol.51(4), pp.467-470 |
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| creator | Tolonen, Ari Pakonen, Minna Hohtola, Anja Jalonen, Jorma |
| description | Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-β-D-glucopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6′-O-β-xylopyranosyl)-O-β-glucopyranoside (8), 4-methoxy-cinnamyl-(6′-O-α-arabinopyranosyl)-O-β-glucopyranoside (9), picein (10) and benzyl-O-β-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant. |
| doi_str_mv | 10.1248/cpb.51.467 |
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(Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-β-D-glucopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6′-O-β-xylopyranosyl)-O-β-glucopyranoside (8), 4-methoxy-cinnamyl-(6′-O-α-arabinopyranosyl)-O-β-glucopyranoside (9), picein (10) and benzyl-O-β-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.51.467</identifier><identifier>PMID: 12673010</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Biological and medical sciences ; Crassulaceae ; General pharmacology ; glycoside ; Glycosides - chemistry ; Glycosides - isolation & purification ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenylpropanoid ; Phenylpropionates - chemistry ; Phenylpropionates - isolation & purification ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Roots ; Rhodiola ; Rhodiola rosea L</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2003, Vol.51(4), pp.467-470</ispartof><rights>2003 The Pharmaceutical Society of Japan</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c689t-ce35c17b9884f5577fcc327491e9ce4184a9f870cae197e16f733a2bd74c02813</citedby><cites>FETCH-LOGICAL-c689t-ce35c17b9884f5577fcc327491e9ce4184a9f870cae197e16f733a2bd74c02813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14738759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12673010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolonen, Ari</creatorcontrib><creatorcontrib>Pakonen, Minna</creatorcontrib><creatorcontrib>Hohtola, Anja</creatorcontrib><creatorcontrib>Jalonen, Jorma</creatorcontrib><creatorcontrib>aDepartment of Chemistry</creatorcontrib><creatorcontrib>University of Oulu</creatorcontrib><creatorcontrib>bDepartment of Biology</creatorcontrib><title>Phenylpropanoid Glycosides from Rhodiola rosea</title><title>Chemical & Pharmaceutical Bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-β-D-glucopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6′-O-β-xylopyranosyl)-O-β-glucopyranoside (8), 4-methoxy-cinnamyl-(6′-O-α-arabinopyranosyl)-O-β-glucopyranoside (9), picein (10) and benzyl-O-β-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant.</description><subject>Biological and medical sciences</subject><subject>Crassulaceae</subject><subject>General pharmacology</subject><subject>glycoside</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - isolation & purification</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenylpropanoid</subject><subject>Phenylpropionates - chemistry</subject><subject>Phenylpropionates - isolation & purification</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Roots</subject><subject>Rhodiola</subject><subject>Rhodiola rosea L</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE-rEzEUxYMovvp04weQguhCmHrz92ZWD3loFR4oouuQZu7YlJlJTdpFv715TGnBzc0iv3vuOYex1xxWXCj7Mew3K81XyuATtuBSYaOFkE_ZAgDaRkgjb9iLUnYAQgPK5-yGC4MSOCzY6seWptOwz2nvpxS75Xo4hVRiR2XZ5zQuf25TF9PglzkV8i_Zs94PhV6d31v2-8vnX_dfm4fv62_3nx6aYGx7aAJJHThuWmtVrzViH4IUqFpObSDFrfJtbxGCJ94icdOjlF5sOlQBhOXylr2fdauxv0cqBzfGEmgY_ETpWBxKblABVPDtf-AuHfNUvTmuDNTsHEylPsxUqClKpt7tcxx9PjkO7rFDVzt0mrvaYYXfnCWPm5G6K3ourQLvzoAvwQ999lOI5coplBZ1W7n1zFWVWME0DXGiq8FQMGxpjE7UIA5Ac1AOhHFQbdSB9RiCEbYq3c1Ku3Lwf-hyyudDDANd3M_jcfvys_XZ0ST_AVWPpEw</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Tolonen, Ari</creator><creator>Pakonen, Minna</creator><creator>Hohtola, Anja</creator><creator>Jalonen, Jorma</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Phenylpropanoid Glycosides from Rhodiola rosea</title><author>Tolonen, Ari ; Pakonen, Minna ; Hohtola, Anja ; Jalonen, Jorma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c689t-ce35c17b9884f5577fcc327491e9ce4184a9f870cae197e16f733a2bd74c02813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Crassulaceae</topic><topic>General pharmacology</topic><topic>glycoside</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - isolation & purification</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenylpropanoid</topic><topic>Phenylpropionates - chemistry</topic><topic>Phenylpropionates - isolation & purification</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Roots</topic><topic>Rhodiola</topic><topic>Rhodiola rosea L</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolonen, Ari</creatorcontrib><creatorcontrib>Pakonen, Minna</creatorcontrib><creatorcontrib>Hohtola, Anja</creatorcontrib><creatorcontrib>Jalonen, Jorma</creatorcontrib><creatorcontrib>aDepartment of Chemistry</creatorcontrib><creatorcontrib>University of Oulu</creatorcontrib><creatorcontrib>bDepartment of Biology</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolonen, Ari</au><au>Pakonen, Minna</au><au>Hohtola, Anja</au><au>Jalonen, Jorma</au><aucorp>aDepartment of Chemistry</aucorp><aucorp>University of Oulu</aucorp><aucorp>bDepartment of Biology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenylpropanoid Glycosides from Rhodiola rosea</atitle><jtitle>Chemical & Pharmaceutical Bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2003</date><risdate>2003</risdate><volume>51</volume><issue>4</issue><spage>467</spage><epage>470</epage><pages>467-470</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-β-D-glucopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6′-O-β-xylopyranosyl)-O-β-glucopyranoside (8), 4-methoxy-cinnamyl-(6′-O-α-arabinopyranosyl)-O-β-glucopyranoside (9), picein (10) and benzyl-O-β-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>12673010</pmid><doi>10.1248/cpb.51.467</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Crassulaceae General pharmacology glycoside Glycosides - chemistry Glycosides - isolation & purification Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenylpropanoid Phenylpropionates - chemistry Phenylpropionates - isolation & purification Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Roots Rhodiola Rhodiola rosea L |
| title | Phenylpropanoid Glycosides from Rhodiola rosea |
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