Conspicuous Ingestion of Staphylococcus aureus Organisms by Murine Fibroblasts In Vitro
A conspicuous adhesion of Staphylococcus aureus organisms to murine cutaneous fibroblasts and NIH/3T3 cells cultured in vitro and subsequent ingestion of S. aureus organisms by these fibroblasts are described. In the present experimental system, only fibroblasts-adhering S. aureus organisms were eff...
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| Veröffentlicht in: | MICROBIOLOGY and IMMUNOLOGY 1992, Vol.36(5), pp.545-550 |
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| container_issue | 5 |
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| container_title | MICROBIOLOGY and IMMUNOLOGY |
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| creator | Usui, Akemi Murai, Miyo Seki, Keiko Sakurada, Junji Masuda, Shogo |
| description | A conspicuous adhesion of Staphylococcus aureus organisms to murine cutaneous fibroblasts and NIH/3T3 cells cultured in vitro and subsequent ingestion of S. aureus organisms by these fibroblasts are described. In the present experimental system, only fibroblasts-adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophyticus. These findings might suggest a correlation between the pathogenesis of S. aureus and its intracellular localization in non-professional phagocytes such as fibroblasts in a special reference to its higher pathogenicity than those of coagulase negative counterparts. |
| doi_str_mv | 10.1111/j.1348-0421.1992.tb02054.x |
| format | Article |
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In the present experimental system, only fibroblasts-adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophyticus. 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In the present experimental system, only fibroblasts-adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophyticus. These findings might suggest a correlation between the pathogenesis of S. aureus and its intracellular localization in non-professional phagocytes such as fibroblasts in a special reference to its higher pathogenicity than those of coagulase negative counterparts.</description><subject>3T3 Cells - immunology</subject><subject>Animals</subject><subject>Bacterial Adhesion - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Endocytosis</subject><subject>Fibroblasts - immunology</subject><subject>Fibroblasts - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Phagocytosis - immunology</subject><subject>Skin - immunology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Staphylococcus aureus - ultrastructure</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV2LEzEUhgdR1u7qTxAGEfFmar4_vFLK7lpsXdDqijchSTPd1PmoyQzb_nszTqleCeYiJ_C-5zkn52TZcwimMJ3X2ynERBSAIDiFUqJpZwAClEz3D7LJSXqYTQAWtKAMgMfZeYxbABBHgpxlZ5BCjJicZLeztok7b_u2j_m82bjY-bbJ2zL_3Ond3aFqbWtt0nQfXAo3YaMbH-uYm0O-7INvXH7lTWhNpWM3IPKvvgvtk-xRqavonh7jRfbl6nI1e18sbq7ns3eLwlKOScHcWmBpECDSGWGsQaJcc4uxsRAZxhgXAjEBJRVIk7LkwAqApC4Fd5TrEl9kL0fuLrQ_-9S9qn20rqp049KXFMeQUUJwMr76pxESiRgECIFkfTNabWhjDK5Uu-BrHQ4KAjUsQG3VMGU1TFkNC1DHBah9Sn52rNOb2q3_pI4TT_qLo66j1VUZdGN9PNko4RIjmmxvR9u9r9zhPxpQy_ny9zMhLkfENnZ6404MHTpvK6dq3aw9lJwrzBQdL0roSbd3OijXJE4xcnzs3P4vzA_FOOZU3X68Vt9XcrX89GGhvuFfm9nKww</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Usui, Akemi</creator><creator>Murai, Miyo</creator><creator>Seki, Keiko</creator><creator>Sakurada, Junji</creator><creator>Masuda, Shogo</creator><general>Blackwell Publishing Ltd</general><general>Center For Academic Publications Japan</general><general>Center for Academic Publications Japan</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Conspicuous Ingestion of Staphylococcus aureus Organisms by Murine Fibroblasts In Vitro</title><author>Usui, Akemi ; Murai, Miyo ; Seki, Keiko ; Sakurada, Junji ; Masuda, Shogo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5734-6ed839b2049eb8bcb28fd7c33bc12b66678826819582a4ff70c8029af87e57af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>3T3 Cells - immunology</topic><topic>Animals</topic><topic>Bacterial Adhesion - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>Endocytosis</topic><topic>Fibroblasts - immunology</topic><topic>Fibroblasts - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Phagocytosis - immunology</topic><topic>Skin - immunology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Staphylococcus aureus - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usui, Akemi</creatorcontrib><creatorcontrib>Murai, Miyo</creatorcontrib><creatorcontrib>Seki, Keiko</creatorcontrib><creatorcontrib>Sakurada, Junji</creatorcontrib><creatorcontrib>Masuda, Shogo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usui, Akemi</au><au>Murai, Miyo</au><au>Seki, Keiko</au><au>Sakurada, Junji</au><au>Masuda, Shogo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conspicuous Ingestion of Staphylococcus aureus Organisms by Murine Fibroblasts In Vitro</atitle><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle><addtitle>Microbiology and Immunology</addtitle><date>1992</date><risdate>1992</risdate><volume>36</volume><issue>5</issue><spage>545</spage><epage>550</epage><pages>545-550</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><coden>MIIMDV</coden><abstract>A conspicuous adhesion of Staphylococcus aureus organisms to murine cutaneous fibroblasts and NIH/3T3 cells cultured in vitro and subsequent ingestion of S. aureus organisms by these fibroblasts are described. In the present experimental system, only fibroblasts-adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophyticus. These findings might suggest a correlation between the pathogenesis of S. aureus and its intracellular localization in non-professional phagocytes such as fibroblasts in a special reference to its higher pathogenicity than those of coagulase negative counterparts.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>1513269</pmid><doi>10.1111/j.1348-0421.1992.tb02054.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0385-5600 |
| ispartof | MICROBIOLOGY and IMMUNOLOGY, 1992, Vol.36(5), pp.545-550 |
| issn | 0385-5600 1348-0421 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Alma/SFX Local Collection |
| subjects | 3T3 Cells - immunology Animals Bacterial Adhesion - immunology Biological and medical sciences Cell physiology Cells, Cultured Endocytosis Fibroblasts - immunology Fibroblasts - ultrastructure Fundamental and applied biological sciences. Psychology Kinetics Mice Molecular and cellular biology Phagocytosis - immunology Skin - immunology Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus aureus - ultrastructure |
| title | Conspicuous Ingestion of Staphylococcus aureus Organisms by Murine Fibroblasts In Vitro |
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