Microenvironmental regulation of Notch signalling in T cell development

T cells develop in the thymus from blood-borne progenitors derived from haematopoietic tissues. Amongst the mechanisms by which stromal cells in thymic and prethymic tissues influence lymphoid progenitors, recent attention has focussed on the importance of Notch signalling in early T cell developmen...

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Veröffentlicht in:	Seminars in immunology 2003-04, Vol.15 (2), p.91-97
Hauptverfasser:	Harman, Benjamin C., Jenkinson, Eric J., Anderson, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins Cell Communication Cell Lineage Hematopoietic Stem Cells - immunology Humans Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Liver - embryology Liver - immunology Lymphoid progenitor Membrane Proteins - agonists Membrane Proteins - physiology Microenvironment Notch Proteins - agonists Receptors, Notch Serrate-Jagged Proteins Signal Transduction Stromal Cells - physiology T cell development T-Lymphocytes - immunology T-Lymphocytes - physiology Thymus Gland - growth & development Thymus Gland - immunology
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