Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers
Cytotoxic T lymphocytes (CTL) are present at high activities in adult patients infected with the human immunodeficiency virus (HIV). In this report, CTL effectors were identified in peripheral blood mononuclear cells (PBMC) of children born to HIV‐1‐infected mothers. These CTL killed HLA‐matched HIV...
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| Veröffentlicht in: | European journal of immunology 1992-09, Vol.22 (9), p.2211-2217 |
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| container_title | European journal of immunology |
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| creator | Cheynier, Rémi Langlade‐Demoyen, Pierre Marescot, Marie‐Rose Blanche, Stephane Blondin, Gilles Wain‐Hobson, Simon Griscelli, Claude Vilmer, Etienne Plata, Fernando |
| description | Cytotoxic T lymphocytes (CTL) are present at high activities in adult patients infected with the human immunodeficiency virus (HIV). In this report, CTL effectors were identified in peripheral blood mononuclear cells (PBMC) of children born to HIV‐1‐infected mothers. These CTL killed HLA‐matched HIV‐1‐infected H9 target cells or doubly transfected P815‐A2‐env, gag or nef mouse tumor cells, which expressed the viral antigens in association with HLA‐A1/A3 or HLA‐A2, respectively. HIV‐1‐specific CTL were detected early after birth (>2 months) and remained present during the asymptomatic phase of the infection. As in HIV‐1‐infected adults, HIV‐specific CTL declined with disease progression. Surprisingly, HIV‐1‐specific CTL were detected in the PBMC of three children who subsequently became seronegative. |
| doi_str_mv | 10.1002/eji.1830220905 |
| format | Article |
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In this report, CTL effectors were identified in peripheral blood mononuclear cells (PBMC) of children born to HIV‐1‐infected mothers. These CTL killed HLA‐matched HIV‐1‐infected H9 target cells or doubly transfected P815‐A2‐env, gag or nef mouse tumor cells, which expressed the viral antigens in association with HLA‐A1/A3 or HLA‐A2, respectively. HIV‐1‐specific CTL were detected early after birth (>2 months) and remained present during the asymptomatic phase of the infection. As in HIV‐1‐infected adults, HIV‐specific CTL declined with disease progression. Surprisingly, HIV‐1‐specific CTL were detected in the PBMC of three children who subsequently became seronegative.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830220905</identifier><identifier>PMID: 1381309</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>AIDS/HIV ; Base Sequence ; Biological and medical sciences ; Child ; Child, Preschool ; Cytotoxicity, Immunologic ; Epitopes ; Female ; HIV Infections - immunology ; HIV-1 - immunology ; HLA-A Antigens - analysis ; human immunodeficiency virus 1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Infant, Newborn ; Killer Cells, Natural - physiology ; Medical sciences ; Molecular Sequence Data ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; T-Lymphocytes, Cytotoxic - immunology</subject><ispartof>European journal of immunology, 1992-09, Vol.22 (9), p.2211-2217</ispartof><rights>Copyright © 1992 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3155-9ff0f05065f6d5bcd8e9784ea28a422a9abffa4cc83c232e5b5075c48681fcaa3</citedby><cites>FETCH-LOGICAL-c3155-9ff0f05065f6d5bcd8e9784ea28a422a9abffa4cc83c232e5b5075c48681fcaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830220905$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830220905$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4339629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1381309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheynier, Rémi</creatorcontrib><creatorcontrib>Langlade‐Demoyen, Pierre</creatorcontrib><creatorcontrib>Marescot, Marie‐Rose</creatorcontrib><creatorcontrib>Blanche, Stephane</creatorcontrib><creatorcontrib>Blondin, Gilles</creatorcontrib><creatorcontrib>Wain‐Hobson, Simon</creatorcontrib><creatorcontrib>Griscelli, Claude</creatorcontrib><creatorcontrib>Vilmer, Etienne</creatorcontrib><creatorcontrib>Plata, Fernando</creatorcontrib><title>Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Cytotoxic T lymphocytes (CTL) are present at high activities in adult patients infected with the human immunodeficiency virus (HIV). In this report, CTL effectors were identified in peripheral blood mononuclear cells (PBMC) of children born to HIV‐1‐infected mothers. These CTL killed HLA‐matched HIV‐1‐infected H9 target cells or doubly transfected P815‐A2‐env, gag or nef mouse tumor cells, which expressed the viral antigens in association with HLA‐A1/A3 or HLA‐A2, respectively. HIV‐1‐specific CTL were detected early after birth (>2 months) and remained present during the asymptomatic phase of the infection. As in HIV‐1‐infected adults, HIV‐specific CTL declined with disease progression. Surprisingly, HIV‐1‐specific CTL were detected in the PBMC of three children who subsequently became seronegative.</description><subject>AIDS/HIV</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytotoxicity, Immunologic</subject><subject>Epitopes</subject><subject>Female</subject><subject>HIV Infections - immunology</subject><subject>HIV-1 - immunology</subject><subject>HLA-A Antigens - analysis</subject><subject>human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Killer Cells, Natural - physiology</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EKkvhyg3JB8Qty_hfYh_RqrRFlbiUc-Q4Y8VVEgc7AXLrI_CMPAmpdkW59TCaw3zzm5E-Qt4y2DMA_hHvwp5pAZyDAfWM7JjirJBMsudkB8BkwY2Gl-RVzncAYEplzsgZE5oJMDtyf1jnOMdfwdFb2q_D1EW3zkgT5imOGTMNI507pBOmMHWYbE-bPsaWRk9dF_o24UibmDYq0m4Z7EjDMCxjbNEHF3B0K_0R0pL_3P9mW4XRo5uxpUPcYlN-TV5422d8c-rn5Nvni9vDVXHz9fL68OmmcIIpVRjvwYOCUvmyVY1rNZpKS7RcW8m5Nbbx3krntHBccFSNgko5qUvNvLNWnJMPx9wpxe8L5rkeQnbY93bEuOS6EqyUFVRPgqwUAkoNG7g_gi7FnBP6ekphsGmtGdQPburNTf3oZlt4d0pemgHbR_woY5u_P81tdrb3yY4u5H-YFMKU_AEzR-xn6HF94mh98eX6vxf-Ak1orCg</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>Cheynier, Rémi</creator><creator>Langlade‐Demoyen, Pierre</creator><creator>Marescot, Marie‐Rose</creator><creator>Blanche, Stephane</creator><creator>Blondin, Gilles</creator><creator>Wain‐Hobson, Simon</creator><creator>Griscelli, Claude</creator><creator>Vilmer, Etienne</creator><creator>Plata, Fernando</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199209</creationdate><title>Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers</title><author>Cheynier, Rémi ; Langlade‐Demoyen, Pierre ; Marescot, Marie‐Rose ; Blanche, Stephane ; Blondin, Gilles ; Wain‐Hobson, Simon ; Griscelli, Claude ; Vilmer, Etienne ; Plata, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3155-9ff0f05065f6d5bcd8e9784ea28a422a9abffa4cc83c232e5b5075c48681fcaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS/HIV</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytotoxicity, Immunologic</topic><topic>Epitopes</topic><topic>Female</topic><topic>HIV Infections - immunology</topic><topic>HIV-1 - immunology</topic><topic>HLA-A Antigens - analysis</topic><topic>human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Killer Cells, Natural - physiology</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheynier, Rémi</creatorcontrib><creatorcontrib>Langlade‐Demoyen, Pierre</creatorcontrib><creatorcontrib>Marescot, Marie‐Rose</creatorcontrib><creatorcontrib>Blanche, Stephane</creatorcontrib><creatorcontrib>Blondin, Gilles</creatorcontrib><creatorcontrib>Wain‐Hobson, Simon</creatorcontrib><creatorcontrib>Griscelli, Claude</creatorcontrib><creatorcontrib>Vilmer, Etienne</creatorcontrib><creatorcontrib>Plata, Fernando</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheynier, Rémi</au><au>Langlade‐Demoyen, Pierre</au><au>Marescot, Marie‐Rose</au><au>Blanche, Stephane</au><au>Blondin, Gilles</au><au>Wain‐Hobson, Simon</au><au>Griscelli, Claude</au><au>Vilmer, Etienne</au><au>Plata, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1992-09</date><risdate>1992</risdate><volume>22</volume><issue>9</issue><spage>2211</spage><epage>2217</epage><pages>2211-2217</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>Cytotoxic T lymphocytes (CTL) are present at high activities in adult patients infected with the human immunodeficiency virus (HIV). In this report, CTL effectors were identified in peripheral blood mononuclear cells (PBMC) of children born to HIV‐1‐infected mothers. These CTL killed HLA‐matched HIV‐1‐infected H9 target cells or doubly transfected P815‐A2‐env, gag or nef mouse tumor cells, which expressed the viral antigens in association with HLA‐A1/A3 or HLA‐A2, respectively. HIV‐1‐specific CTL were detected early after birth (>2 months) and remained present during the asymptomatic phase of the infection. As in HIV‐1‐infected adults, HIV‐specific CTL declined with disease progression. Surprisingly, HIV‐1‐specific CTL were detected in the PBMC of three children who subsequently became seronegative.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>1381309</pmid><doi>10.1002/eji.1830220905</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1992-09, Vol.22 (9), p.2211-2217 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73164707 |
| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | AIDS/HIV Base Sequence Biological and medical sciences Child Child, Preschool Cytotoxicity, Immunologic Epitopes Female HIV Infections - immunology HIV-1 - immunology HLA-A Antigens - analysis human immunodeficiency virus 1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Infant, Newborn Killer Cells, Natural - physiology Medical sciences Molecular Sequence Data Pregnancy Pregnancy Complications, Infectious - immunology T-Lymphocytes, Cytotoxic - immunology |
| title | Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers |
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