Cardiac valve replacement in patients infected with the human immunodeficiency virus

Major surgical procedures, especially when performed under general anesthesia, can depress immunological parameters measured in vitro. Therefore concern has been expressed that operation might have an adverse effect on the immune status of individuals infected with the human immunodeficiency virus (...

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Veröffentlicht in:The Annals of thoracic surgery 1992-09, Vol.54 (3), p.552-554
Hauptverfasser: Bräu, Norbert, Esposito, Rick A., Simberkoff, Michael S.
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container_title The Annals of thoracic surgery
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creator Bräu, Norbert
Esposito, Rick A.
Simberkoff, Michael S.
description Major surgical procedures, especially when performed under general anesthesia, can depress immunological parameters measured in vitro. Therefore concern has been expressed that operation might have an adverse effect on the immune status of individuals infected with the human immunodeficiency virus (HIV). Four HIV-positive patients without symptoms of HIV disease underwent cardiac valve replacement in consequence of infective endocarditis. After up to 15 months postoperalively, 3 patients are alive and well without signs of progressive immunodeficiency or recurrent endocarditis. One patient died of recurrent endocarditis without evidence of HIV-related disease on autopsy. Cardiac operation does not seem to accelerate HIV-related immunodeficiency.
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subjects Adult
AIDS/HIV
Biological and medical sciences
Bioprosthesis
Endocarditis, Bacterial - complications
Endocarditis, Bacterial - surgery
Heart Valve Diseases - complications
Heart Valve Diseases - surgery
Heart Valve Prosthesis
HIV Infections - complications
Humans
Male
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
title Cardiac valve replacement in patients infected with the human immunodeficiency virus
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