Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection
We examined testing, referral, and treatment of patients with hepatitis C among HIV-infected patients in the Veterans Aging 3-Site Cohort Study by using patient- and provider-completed surveys and laboratory, pharmacy, and administrative records from the Department of Veterans Affairs electronic med...
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| Veröffentlicht in: | Clinical infectious diseases 2003-04, Vol.36 (8), p.1039-1046 |
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| container_title | Clinical infectious diseases |
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| creator | Fultz, Shawn L. Justice, Amy C. Butt, Adeel A. Rabeneck, Linda Weissman, Sharon Rodriguez-Barradas, Maria |
| description | We examined testing, referral, and treatment of patients with hepatitis C among HIV-infected patients in the Veterans Aging 3-Site Cohort Study by using patient- and provider-completed surveys and laboratory, pharmacy, and administrative records from the Department of Veterans Affairs electronic medical record. Of 881 human immunodeficiency virus-positive patients, 43% were coinfected with hepatitis C virus. Of these, 88 (30%) reported current alcohol consumption. Only one-third were counseled to reduce or stop alcohol consumption. Coinfected patients with indications for hepatitis C treatment had a high rate of contraindications, including both medical and psychiatric comorbidities. Of the 65 patients with indications for hepatitis C therapy and free of contraindications for treatment, only 18% underwent liver biopsy and 3% received IFN. Although treatment indications are common in this population, contraindications are also common. Health care providers are often unaware of alcohol consumption that may accelerate the course of hepatitis C, increase the risk of hepatocellular carcinoma, and reduce treatment efficacy. |
| doi_str_mv | 10.1086/374049 |
| format | Article |
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Of 881 human immunodeficiency virus-positive patients, 43% were coinfected with hepatitis C virus. Of these, 88 (30%) reported current alcohol consumption. Only one-third were counseled to reduce or stop alcohol consumption. Coinfected patients with indications for hepatitis C treatment had a high rate of contraindications, including both medical and psychiatric comorbidities. Of the 65 patients with indications for hepatitis C therapy and free of contraindications for treatment, only 18% underwent liver biopsy and 3% received IFN. Although treatment indications are common in this population, contraindications are also common. Health care providers are often unaware of alcohol consumption that may accelerate the course of hepatitis C, increase the risk of hepatocellular carcinoma, and reduce treatment efficacy.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/374049</identifier><identifier>PMID: 12684917</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; Alcohol Drinking - adverse effects ; Alcohols ; Antiviral Agents - therapeutic use ; Antivirals ; Biological and medical sciences ; Biopsies ; Carcinoma, Hepatocellular - etiology ; Female ; Hepacivirus ; Hepacivirus - drug effects ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - drug therapy ; HIV ; HIV - drug effects ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV/AIDS ; Human viral diseases ; Humans ; Illicit drugs ; Infections ; Infectious diseases ; Liver ; Male ; Medical sciences ; Middle Aged ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral hepatitis ; Viruses</subject><ispartof>Clinical infectious diseases, 2003-04, Vol.36 (8), p.1039-1046</ispartof><rights>Copyright 2003 The Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-2a357ffb2273c9538ad04fa1aaf3cb030047dfc45f9ed84fac115c2629481a123</citedby><cites>FETCH-LOGICAL-c453t-2a357ffb2273c9538ad04fa1aaf3cb030047dfc45f9ed84fac115c2629481a123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4483431$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4483431$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14843678$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12684917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fultz, Shawn L.</creatorcontrib><creatorcontrib>Justice, Amy C.</creatorcontrib><creatorcontrib>Butt, Adeel A.</creatorcontrib><creatorcontrib>Rabeneck, Linda</creatorcontrib><creatorcontrib>Weissman, Sharon</creatorcontrib><creatorcontrib>Rodriguez-Barradas, Maria</creatorcontrib><creatorcontrib>VACS-3 Project Team</creatorcontrib><creatorcontrib>the VACS‐3 Project Team</creatorcontrib><title>Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>We examined testing, referral, and treatment of patients with hepatitis C among HIV-infected patients in the Veterans Aging 3-Site Cohort Study by using patient- and provider-completed surveys and laboratory, pharmacy, and administrative records from the Department of Veterans Affairs electronic medical record. Of 881 human immunodeficiency virus-positive patients, 43% were coinfected with hepatitis C virus. Of these, 88 (30%) reported current alcohol consumption. Only one-third were counseled to reduce or stop alcohol consumption. Coinfected patients with indications for hepatitis C treatment had a high rate of contraindications, including both medical and psychiatric comorbidities. Of the 65 patients with indications for hepatitis C therapy and free of contraindications for treatment, only 18% underwent liver biopsy and 3% received IFN. Although treatment indications are common in this population, contraindications are also common. Health care providers are often unaware of alcohol consumption that may accelerate the course of hepatitis C, increase the risk of hepatocellular carcinoma, and reduce treatment efficacy.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohols</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antivirals</subject><subject>Biological and medical sciences</subject><subject>Biopsies</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Female</subject><subject>Hepacivirus</subject><subject>Hepacivirus - drug effects</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - drug therapy</subject><subject>HIV</subject><subject>HIV - drug effects</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV/AIDS</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Illicit drugs</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Liver</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral hepatitis</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-KFDEQxhtR3D_qE4jEw3ra1qSTTtJHGdQZWFBkHMRLqEknbtbuZDZJo_sUvrKRbne9iKcq6vvVF6gvVfWE4JcES_6KCoZZd686Ji0VNW87cr_0uJU1k1QeVScpXWFMiMTtw-qINFyyjojj6ufWpOz813P00VgTIwznCHyPttFAHo3P6APkbKJPyIaI1uYA2WWX0ArtXJxKDc5bo7MLHjmPoAwuQ8woWLQzZRHK5neXL9F6GsGjzThOPvTGOu2M1zeLy-aPx6PqgYUhmcdLPa0-vX2zXa3ri_fvNqvXF7VmLc11A7QV1u6bRlDdtVRCj5kFAmCp3mOKMRO9LaztTC-LoglpdcObjkkCpKGn1YvZ9xDD9VRuoEaXtBkG8CZMSQlKOBX8_yCRkndY_gXqGFKKxqpDdCPEG0Ww-p2RmjMq4LPFcdqPpr_DllAKcLYAkDQMttxQu3THMckoF7Jwz2cuTId_P_Z0Zq5SDvGWYuVXMEqKXM-yS9n8uJUhflNcUNGq9ecvqiFUbhu-Uzv6Cx0Uu90</recordid><startdate>20030415</startdate><enddate>20030415</enddate><creator>Fultz, Shawn L.</creator><creator>Justice, Amy C.</creator><creator>Butt, Adeel A.</creator><creator>Rabeneck, Linda</creator><creator>Weissman, Sharon</creator><creator>Rodriguez-Barradas, Maria</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030415</creationdate><title>Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection</title><author>Fultz, Shawn L. ; Justice, Amy C. ; Butt, Adeel A. ; Rabeneck, Linda ; Weissman, Sharon ; Rodriguez-Barradas, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-2a357ffb2273c9538ad04fa1aaf3cb030047dfc45f9ed84fac115c2629481a123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohols</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Antivirals</topic><topic>Biological and medical sciences</topic><topic>Biopsies</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Female</topic><topic>Hepacivirus</topic><topic>Hepacivirus - drug effects</topic><topic>Hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - drug therapy</topic><topic>HIV</topic><topic>HIV - drug effects</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV/AIDS</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Illicit drugs</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Liver</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral hepatitis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fultz, Shawn L.</creatorcontrib><creatorcontrib>Justice, Amy C.</creatorcontrib><creatorcontrib>Butt, Adeel A.</creatorcontrib><creatorcontrib>Rabeneck, Linda</creatorcontrib><creatorcontrib>Weissman, Sharon</creatorcontrib><creatorcontrib>Rodriguez-Barradas, Maria</creatorcontrib><creatorcontrib>VACS-3 Project Team</creatorcontrib><creatorcontrib>the VACS‐3 Project Team</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fultz, Shawn L.</au><au>Justice, Amy C.</au><au>Butt, Adeel A.</au><au>Rabeneck, Linda</au><au>Weissman, Sharon</au><au>Rodriguez-Barradas, Maria</au><aucorp>VACS-3 Project Team</aucorp><aucorp>the VACS‐3 Project Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2003-04-15</date><risdate>2003</risdate><volume>36</volume><issue>8</issue><spage>1039</spage><epage>1046</epage><pages>1039-1046</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>We examined testing, referral, and treatment of patients with hepatitis C among HIV-infected patients in the Veterans Aging 3-Site Cohort Study by using patient- and provider-completed surveys and laboratory, pharmacy, and administrative records from the Department of Veterans Affairs electronic medical record. Of 881 human immunodeficiency virus-positive patients, 43% were coinfected with hepatitis C virus. Of these, 88 (30%) reported current alcohol consumption. Only one-third were counseled to reduce or stop alcohol consumption. Coinfected patients with indications for hepatitis C treatment had a high rate of contraindications, including both medical and psychiatric comorbidities. Of the 65 patients with indications for hepatitis C therapy and free of contraindications for treatment, only 18% underwent liver biopsy and 3% received IFN. Although treatment indications are common in this population, contraindications are also common. Health care providers are often unaware of alcohol consumption that may accelerate the course of hepatitis C, increase the risk of hepatocellular carcinoma, and reduce treatment efficacy.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12684917</pmid><doi>10.1086/374049</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 2003-04, Vol.36 (8), p.1039-1046 |
| issn | 1058-4838 1537-6591 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Alcohol Drinking - adverse effects Alcohols Antiviral Agents - therapeutic use Antivirals Biological and medical sciences Biopsies Carcinoma, Hepatocellular - etiology Female Hepacivirus Hepacivirus - drug effects Hepatitis C Hepatitis C - complications Hepatitis C - drug therapy HIV HIV - drug effects HIV Infections - complications HIV Infections - drug therapy HIV/AIDS Human viral diseases Humans Illicit drugs Infections Infectious diseases Liver Male Medical sciences Middle Aged Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis Viruses |
| title | Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection |
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