C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study
Objective: We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have assessed the relationship between markers of inflammation or nutrition and mortality. Design: Two-year p...
Gespeichert in:
| Veröffentlicht in: | Journal of renal nutrition 2003-04, Vol.13 (2), p.137-143 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 143 |
|---|---|
| container_issue | 2 |
| container_start_page | 137 |
| container_title | Journal of renal nutrition |
| container_volume | 13 |
| creator | Chauveau, Philippe Level, Claude Lasseur, Catherine Bonarek, Hervé Peuchant, Evelyne Montaudon, Danièle Vendrely, Benoît Combe, Christian |
| description | Objective: We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have assessed the relationship between markers of inflammation or nutrition and mortality. Design: Two-year prospective study, in 61 patients dialyzed in our unit (29 M/32 F, age 63 ± 15 years, on dialysis for 76 ± 94 months, 12 hrs/wk, on high-flux (HF) membrane for 25 patients and low-flux (LF) for 36 patients, without reuse). Kt/V was 1.53 ± 0.30. Setting: Hospital-based dialysis unit. Main Outcome Measure: CRP, PCT, ferritin, albumin, and prealbumin, were measured in 04/99 (T0) and every 6 months thereafter. Interleukin-6 (IL6) and fibrinogen were measured at the start of study. The outcome and the causes of death of patients were noted in 58 patients, 3 patients were lost of follow-up. Results: The mortality (24 deaths) was 42% at 2 years in this hospital based unit. The main causes of mortality were cardiovascular diseases (71%) and infection (17%). Patients were classified according to their CRP (CRP+ if CRP ≥ 5 mg/L; n = 40), and PCT values (PCT + if PCT ≥ 0.5 ng/mL; n = 25). IL6 level was ≥ 10 pg/mL for 95% of the patients. Mortality was higher in the CRP+ group (Kaplan-Meier test P |
| doi_str_mv | 10.1053/jren.2003.50017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73161815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1051227603000050</els_id><sourcerecordid>73161815</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-bd7eecec4ea8a28c36ccfc5bfa19756fc94f81194360bd8dc60e4a81af4168043</originalsourceid><addsrcrecordid>eNp1kLtPwzAQhy0EolCY2ZAntrR2nIfDVlW8pEosMFuOfREuedV2KuW_xyGVmJh8sj__7u5D6I6SFSUpW-8ttKuYELZKCaH5GbqiKYsjnhJ2HmqS0iiO82yBrp3bB4KmPL5ECxpnOeWMX6HDNrIglTdHwL3tPJgWy1ZPtZK1Mr5rpxuHG2m_wTrcVbjprJe18SMOT1_QdNrIenTG4V56A613j3iD42gEaacg18PcwPlBjzfoopK1g9vTuUSfz08f29do9_7ytt3sIpWQwkelzgEUqAQklzFXLFOqUmlZSVrkaVapIqk4pUXCMlJqrlVGIJGcyiqhGScJW6KHOTdMcBjAedEYp6CuZQvd4ETOaEZ50LVE6xlUYVRnoRK9NWHdUVAiJstisiwmy-LXcvhxf4oeygb0H3_SGoBiBiAseDRghVNBjAJtbHAhdGf-Df8Br0SOtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73161815</pqid></control><display><type>article</type><title>C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chauveau, Philippe ; Level, Claude ; Lasseur, Catherine ; Bonarek, Hervé ; Peuchant, Evelyne ; Montaudon, Danièle ; Vendrely, Benoît ; Combe, Christian</creator><creatorcontrib>Chauveau, Philippe ; Level, Claude ; Lasseur, Catherine ; Bonarek, Hervé ; Peuchant, Evelyne ; Montaudon, Danièle ; Vendrely, Benoît ; Combe, Christian</creatorcontrib><description>Objective: We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have assessed the relationship between markers of inflammation or nutrition and mortality. Design: Two-year prospective study, in 61 patients dialyzed in our unit (29 M/32 F, age 63 ± 15 years, on dialysis for 76 ± 94 months, 12 hrs/wk, on high-flux (HF) membrane for 25 patients and low-flux (LF) for 36 patients, without reuse). Kt/V was 1.53 ± 0.30. Setting: Hospital-based dialysis unit. Main Outcome Measure: CRP, PCT, ferritin, albumin, and prealbumin, were measured in 04/99 (T0) and every 6 months thereafter. Interleukin-6 (IL6) and fibrinogen were measured at the start of study. The outcome and the causes of death of patients were noted in 58 patients, 3 patients were lost of follow-up. Results: The mortality (24 deaths) was 42% at 2 years in this hospital based unit. The main causes of mortality were cardiovascular diseases (71%) and infection (17%). Patients were classified according to their CRP (CRP+ if CRP ≥ 5 mg/L; n = 40), and PCT values (PCT + if PCT ≥ 0.5 ng/mL; n = 25). IL6 level was ≥ 10 pg/mL for 95% of the patients. Mortality was higher in the CRP+ group (Kaplan-Meier test P <.01) but not in the PCT or IL6 positive patients. All patients of the CRP+ group at T0 remained CRP+. Only 56% of patients of PCT+ remained positive at 6 months. When patients were grouped according to CRP quartile the difference on survival remained significant (P =.03), patients who were classified in the third and fourth quartile (upper than 9.9 mg/L), exhibited a higher rate of mortality than the lower quartile. The concomitant presence of a high level of PCT and CRP was associated with a worsened nutritional status at T0 but PCT level had no influence on 2-year mortality. Conclusion: In this 2-year prospective study in a hospital-based cohort of high-risk hemodialysis patients, elevated CRP, but not raised PCT, was associated with increased mortality. Inflammation remained present throughout a 2-year follow-up in patients with an initial CRP higher than 5 mg/L. An upper value of CRP above 9.9 mg/L is independly predictive of mortality, mainly from cardiovascular causes. The association of high PCT and CRP was no more predictive of mortality than high CRP. © 2003 by the National Kidney Foundation, Inc.</description><identifier>ISSN: 1051-2276</identifier><identifier>EISSN: 1532-8503</identifier><identifier>DOI: 10.1053/jren.2003.50017</identifier><identifier>PMID: 12671838</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Biomarkers - blood ; C-Reactive Protein - analysis ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Cardiovascular Diseases - mortality ; Female ; Humans ; Infection - mortality ; Male ; Middle Aged ; Nutritional Status ; Prospective Studies ; Protein Precursors - blood ; Renal Dialysis - mortality</subject><ispartof>Journal of renal nutrition, 2003-04, Vol.13 (2), p.137-143</ispartof><rights>2003 National Kidney Foundation, Inc</rights><rights>Copyright 2003 by the National Kidney Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-bd7eecec4ea8a28c36ccfc5bfa19756fc94f81194360bd8dc60e4a81af4168043</citedby><cites>FETCH-LOGICAL-c409t-bd7eecec4ea8a28c36ccfc5bfa19756fc94f81194360bd8dc60e4a81af4168043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1051227603000050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12671838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chauveau, Philippe</creatorcontrib><creatorcontrib>Level, Claude</creatorcontrib><creatorcontrib>Lasseur, Catherine</creatorcontrib><creatorcontrib>Bonarek, Hervé</creatorcontrib><creatorcontrib>Peuchant, Evelyne</creatorcontrib><creatorcontrib>Montaudon, Danièle</creatorcontrib><creatorcontrib>Vendrely, Benoît</creatorcontrib><creatorcontrib>Combe, Christian</creatorcontrib><title>C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study</title><title>Journal of renal nutrition</title><addtitle>J Ren Nutr</addtitle><description>Objective: We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have assessed the relationship between markers of inflammation or nutrition and mortality. Design: Two-year prospective study, in 61 patients dialyzed in our unit (29 M/32 F, age 63 ± 15 years, on dialysis for 76 ± 94 months, 12 hrs/wk, on high-flux (HF) membrane for 25 patients and low-flux (LF) for 36 patients, without reuse). Kt/V was 1.53 ± 0.30. Setting: Hospital-based dialysis unit. Main Outcome Measure: CRP, PCT, ferritin, albumin, and prealbumin, were measured in 04/99 (T0) and every 6 months thereafter. Interleukin-6 (IL6) and fibrinogen were measured at the start of study. The outcome and the causes of death of patients were noted in 58 patients, 3 patients were lost of follow-up. Results: The mortality (24 deaths) was 42% at 2 years in this hospital based unit. The main causes of mortality were cardiovascular diseases (71%) and infection (17%). Patients were classified according to their CRP (CRP+ if CRP ≥ 5 mg/L; n = 40), and PCT values (PCT + if PCT ≥ 0.5 ng/mL; n = 25). IL6 level was ≥ 10 pg/mL for 95% of the patients. Mortality was higher in the CRP+ group (Kaplan-Meier test P <.01) but not in the PCT or IL6 positive patients. All patients of the CRP+ group at T0 remained CRP+. Only 56% of patients of PCT+ remained positive at 6 months. When patients were grouped according to CRP quartile the difference on survival remained significant (P =.03), patients who were classified in the third and fourth quartile (upper than 9.9 mg/L), exhibited a higher rate of mortality than the lower quartile. The concomitant presence of a high level of PCT and CRP was associated with a worsened nutritional status at T0 but PCT level had no influence on 2-year mortality. Conclusion: In this 2-year prospective study in a hospital-based cohort of high-risk hemodialysis patients, elevated CRP, but not raised PCT, was associated with increased mortality. Inflammation remained present throughout a 2-year follow-up in patients with an initial CRP higher than 5 mg/L. An upper value of CRP above 9.9 mg/L is independly predictive of mortality, mainly from cardiovascular causes. The association of high PCT and CRP was no more predictive of mortality than high CRP. © 2003 by the National Kidney Foundation, Inc.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Female</subject><subject>Humans</subject><subject>Infection - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>Prospective Studies</subject><subject>Protein Precursors - blood</subject><subject>Renal Dialysis - mortality</subject><issn>1051-2276</issn><issn>1532-8503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtPwzAQhy0EolCY2ZAntrR2nIfDVlW8pEosMFuOfREuedV2KuW_xyGVmJh8sj__7u5D6I6SFSUpW-8ttKuYELZKCaH5GbqiKYsjnhJ2HmqS0iiO82yBrp3bB4KmPL5ECxpnOeWMX6HDNrIglTdHwL3tPJgWy1ZPtZK1Mr5rpxuHG2m_wTrcVbjprJe18SMOT1_QdNrIenTG4V56A613j3iD42gEaacg18PcwPlBjzfoopK1g9vTuUSfz08f29do9_7ytt3sIpWQwkelzgEUqAQklzFXLFOqUmlZSVrkaVapIqk4pUXCMlJqrlVGIJGcyiqhGScJW6KHOTdMcBjAedEYp6CuZQvd4ETOaEZ50LVE6xlUYVRnoRK9NWHdUVAiJstisiwmy-LXcvhxf4oeygb0H3_SGoBiBiAseDRghVNBjAJtbHAhdGf-Df8Br0SOtg</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Chauveau, Philippe</creator><creator>Level, Claude</creator><creator>Lasseur, Catherine</creator><creator>Bonarek, Hervé</creator><creator>Peuchant, Evelyne</creator><creator>Montaudon, Danièle</creator><creator>Vendrely, Benoît</creator><creator>Combe, Christian</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study</title><author>Chauveau, Philippe ; Level, Claude ; Lasseur, Catherine ; Bonarek, Hervé ; Peuchant, Evelyne ; Montaudon, Danièle ; Vendrely, Benoît ; Combe, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-bd7eecec4ea8a28c36ccfc5bfa19756fc94f81194360bd8dc60e4a81af4168043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Female</topic><topic>Humans</topic><topic>Infection - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>Prospective Studies</topic><topic>Protein Precursors - blood</topic><topic>Renal Dialysis - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chauveau, Philippe</creatorcontrib><creatorcontrib>Level, Claude</creatorcontrib><creatorcontrib>Lasseur, Catherine</creatorcontrib><creatorcontrib>Bonarek, Hervé</creatorcontrib><creatorcontrib>Peuchant, Evelyne</creatorcontrib><creatorcontrib>Montaudon, Danièle</creatorcontrib><creatorcontrib>Vendrely, Benoît</creatorcontrib><creatorcontrib>Combe, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of renal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chauveau, Philippe</au><au>Level, Claude</au><au>Lasseur, Catherine</au><au>Bonarek, Hervé</au><au>Peuchant, Evelyne</au><au>Montaudon, Danièle</au><au>Vendrely, Benoît</au><au>Combe, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study</atitle><jtitle>Journal of renal nutrition</jtitle><addtitle>J Ren Nutr</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>13</volume><issue>2</issue><spage>137</spage><epage>143</epage><pages>137-143</pages><issn>1051-2276</issn><eissn>1532-8503</eissn><abstract>Objective: We have previously shown in a transversal study that PCT combined to CRP is associated to an altered nutritional status in hemodialysis patients. In a 2-year prospective study, we have assessed the relationship between markers of inflammation or nutrition and mortality. Design: Two-year prospective study, in 61 patients dialyzed in our unit (29 M/32 F, age 63 ± 15 years, on dialysis for 76 ± 94 months, 12 hrs/wk, on high-flux (HF) membrane for 25 patients and low-flux (LF) for 36 patients, without reuse). Kt/V was 1.53 ± 0.30. Setting: Hospital-based dialysis unit. Main Outcome Measure: CRP, PCT, ferritin, albumin, and prealbumin, were measured in 04/99 (T0) and every 6 months thereafter. Interleukin-6 (IL6) and fibrinogen were measured at the start of study. The outcome and the causes of death of patients were noted in 58 patients, 3 patients were lost of follow-up. Results: The mortality (24 deaths) was 42% at 2 years in this hospital based unit. The main causes of mortality were cardiovascular diseases (71%) and infection (17%). Patients were classified according to their CRP (CRP+ if CRP ≥ 5 mg/L; n = 40), and PCT values (PCT + if PCT ≥ 0.5 ng/mL; n = 25). IL6 level was ≥ 10 pg/mL for 95% of the patients. Mortality was higher in the CRP+ group (Kaplan-Meier test P <.01) but not in the PCT or IL6 positive patients. All patients of the CRP+ group at T0 remained CRP+. Only 56% of patients of PCT+ remained positive at 6 months. When patients were grouped according to CRP quartile the difference on survival remained significant (P =.03), patients who were classified in the third and fourth quartile (upper than 9.9 mg/L), exhibited a higher rate of mortality than the lower quartile. The concomitant presence of a high level of PCT and CRP was associated with a worsened nutritional status at T0 but PCT level had no influence on 2-year mortality. Conclusion: In this 2-year prospective study in a hospital-based cohort of high-risk hemodialysis patients, elevated CRP, but not raised PCT, was associated with increased mortality. Inflammation remained present throughout a 2-year follow-up in patients with an initial CRP higher than 5 mg/L. An upper value of CRP above 9.9 mg/L is independly predictive of mortality, mainly from cardiovascular causes. The association of high PCT and CRP was no more predictive of mortality than high CRP. © 2003 by the National Kidney Foundation, Inc.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12671838</pmid><doi>10.1053/jren.2003.50017</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1051-2276 |
| ispartof | Journal of renal nutrition, 2003-04, Vol.13 (2), p.137-143 |
| issn | 1051-2276 1532-8503 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73161815 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Biomarkers - blood C-Reactive Protein - analysis Calcitonin - blood Calcitonin Gene-Related Peptide Cardiovascular Diseases - mortality Female Humans Infection - mortality Male Middle Aged Nutritional Status Prospective Studies Protein Precursors - blood Renal Dialysis - mortality |
| title | C-reactive protein and procalcitonin as markers of mortality in hemodialysis patients: A 2-year prospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A06%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=C-reactive%20protein%20and%20procalcitonin%20as%20markers%20of%20mortality%20in%20hemodialysis%20patients:%20A%202-year%20prospective%20study&rft.jtitle=Journal%20of%20renal%20nutrition&rft.au=Chauveau,%20Philippe&rft.date=2003-04-01&rft.volume=13&rft.issue=2&rft.spage=137&rft.epage=143&rft.pages=137-143&rft.issn=1051-2276&rft.eissn=1532-8503&rft_id=info:doi/10.1053/jren.2003.50017&rft_dat=%3Cproquest_cross%3E73161815%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73161815&rft_id=info:pmid/12671838&rft_els_id=S1051227603000050&rfr_iscdi=true |