Effects of Cycling and Rigor Crossbridges on the Conformation of Cardiac Troponin C

The results of work by several investigators indicate that crossbridge attachment serves as a positive feedback mechanism that transiently increases the Ca affinity of troponin C (TnC) during each normal heartbeat. To monitor structural changes in the cardiac isoform of TnC (cTnC) associated with Ca...

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Veröffentlicht in:	Circulation research 1992-10, Vol.71 (4), p.984-991
Hauptverfasser:	Hannon, James D, Martyn, Donald A, Gordon, Albert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Fluorescent Dyes Fundamental and applied biological sciences. Psychology Heart Heart Rate In Vitro Techniques Male Muscle Contraction Muscles - metabolism Muscles - physiology Myocardial Contraction Myocardium - metabolism Naphthalenesulfonates Rats Rats, Inbred Strains Sarcomeres - metabolism Sarcomeres - physiology Troponin - metabolism Troponin - physiology Troponin C Vertebrates: cardiovascular system
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