Acute Effects of Hyperoxia on Dyspnea in Hypoxemia Patients With Chronic Airway Obstruction at Rest
Supplemental oxygen is used in hypoxemic patients with chronic airways obstruction (CAO) because it reduces pulmonary artery pressure and prolongs life. The purpose of this study was to assess at rest the effects of 30% oxygen inhalation on dyspnea, breathing pattern, neuromuscular inspiratory drive...
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| Veröffentlicht in: | Chest 2003-04, Vol.123 (4), p.1038-1046 |
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| creator | Alvisi, Valentina Mirkovic, Tomislav Nesme, Pascal Guérin, Claude Milic-Emili, Joseph |
| description | Supplemental oxygen is used in hypoxemic patients with chronic airways obstruction (CAO) because it reduces pulmonary artery pressure and prolongs life. The purpose of this study was to assess at rest the effects of 30% oxygen inhalation on dyspnea, breathing pattern, neuromuscular inspiratory drive based on measurement of mouth occlusion pressure (P0.1), and dynamic hyperinflation (DH), as reflected by changes in inspiratory capacity (IC).
Ten patients with stable CAO receiving long-term oxygen were studied at rest, before and after 5, 15, and 25 min of oxygen administration. Severity of dyspnea was rated using the visual analog scale (VAS). Breathing pattern parameters, P0.1, IC, and tidal expiratory flow limitation (EFL), were measured sequentially.
Eight patients exhibited EFL under baseline condition. During 30% oxygen breathing, the VAS score significantly decreased, associated with a concurrent increase of IC (11%). There was also a significant reduction of minute ventilation and tidal volume (11% and 12%, respectively), which was due to a significant decrease of mean inspiratory flow. Although not significantly, P0.1 decreased by 13%. Finally, two patients reverted from EFL to no EFL.
Patients with CAO receiving long-term oxygen may benefit from hyperoxic breathing at rest, since it decreases the ventilation and the degree of DH, with concurrent improvement of dyspnea sensation. |
| doi_str_mv | 10.1378/chest.123.4.1038 |
| format | Article |
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Ten patients with stable CAO receiving long-term oxygen were studied at rest, before and after 5, 15, and 25 min of oxygen administration. Severity of dyspnea was rated using the visual analog scale (VAS). Breathing pattern parameters, P0.1, IC, and tidal expiratory flow limitation (EFL), were measured sequentially.
Eight patients exhibited EFL under baseline condition. During 30% oxygen breathing, the VAS score significantly decreased, associated with a concurrent increase of IC (11%). There was also a significant reduction of minute ventilation and tidal volume (11% and 12%, respectively), which was due to a significant decrease of mean inspiratory flow. Although not significantly, P0.1 decreased by 13%. Finally, two patients reverted from EFL to no EFL.
Patients with CAO receiving long-term oxygen may benefit from hyperoxic breathing at rest, since it decreases the ventilation and the degree of DH, with concurrent improvement of dyspnea sensation.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.123.4.1038</identifier><identifier>PMID: 12684291</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Airway management ; Biological and medical sciences ; breathing pattern ; COPD ; Diseases of the respiratory system ; dynamic hyperinflation ; Dyspnea ; Dyspnea - etiology ; Dyspnea - physiopathology ; Dyspnea - therapy ; Gas flow ; Humans ; Hypoxia - etiology ; Hypoxia - physiopathology ; Hypoxia - therapy ; Inspiratory Capacity ; Male ; Medical sciences ; Middle Aged ; mouth occlusion pressure ; oxygen ; Oxygen Inhalation Therapy ; Patients ; Pulmonary arteries ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Respiratory Function Tests ; Spirometry ; Treatment Outcome</subject><ispartof>Chest, 2003-04, Vol.123 (4), p.1038-1046</ispartof><rights>2003 The American College of Chest Physicians</rights><rights>2003 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Apr 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-f5f1c182d5754afc2d26c269bf0ed96f2d37edc50448eb0c669eccc08b4650753</citedby><cites>FETCH-LOGICAL-c444t-f5f1c182d5754afc2d26c269bf0ed96f2d37edc50448eb0c669eccc08b4650753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14687486$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12684291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvisi, Valentina</creatorcontrib><creatorcontrib>Mirkovic, Tomislav</creatorcontrib><creatorcontrib>Nesme, Pascal</creatorcontrib><creatorcontrib>Guérin, Claude</creatorcontrib><creatorcontrib>Milic-Emili, Joseph</creatorcontrib><title>Acute Effects of Hyperoxia on Dyspnea in Hypoxemia Patients With Chronic Airway Obstruction at Rest</title><title>Chest</title><addtitle>Chest</addtitle><description>Supplemental oxygen is used in hypoxemic patients with chronic airways obstruction (CAO) because it reduces pulmonary artery pressure and prolongs life. The purpose of this study was to assess at rest the effects of 30% oxygen inhalation on dyspnea, breathing pattern, neuromuscular inspiratory drive based on measurement of mouth occlusion pressure (P0.1), and dynamic hyperinflation (DH), as reflected by changes in inspiratory capacity (IC).
Ten patients with stable CAO receiving long-term oxygen were studied at rest, before and after 5, 15, and 25 min of oxygen administration. Severity of dyspnea was rated using the visual analog scale (VAS). Breathing pattern parameters, P0.1, IC, and tidal expiratory flow limitation (EFL), were measured sequentially.
Eight patients exhibited EFL under baseline condition. During 30% oxygen breathing, the VAS score significantly decreased, associated with a concurrent increase of IC (11%). There was also a significant reduction of minute ventilation and tidal volume (11% and 12%, respectively), which was due to a significant decrease of mean inspiratory flow. Although not significantly, P0.1 decreased by 13%. Finally, two patients reverted from EFL to no EFL.
Patients with CAO receiving long-term oxygen may benefit from hyperoxic breathing at rest, since it decreases the ventilation and the degree of DH, with concurrent improvement of dyspnea sensation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Airway management</subject><subject>Biological and medical sciences</subject><subject>breathing pattern</subject><subject>COPD</subject><subject>Diseases of the respiratory system</subject><subject>dynamic hyperinflation</subject><subject>Dyspnea</subject><subject>Dyspnea - etiology</subject><subject>Dyspnea - physiopathology</subject><subject>Dyspnea - therapy</subject><subject>Gas flow</subject><subject>Humans</subject><subject>Hypoxia - etiology</subject><subject>Hypoxia - physiopathology</subject><subject>Hypoxia - therapy</subject><subject>Inspiratory Capacity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mouth occlusion pressure</subject><subject>oxygen</subject><subject>Oxygen Inhalation Therapy</subject><subject>Patients</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Radiotherapy. 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The purpose of this study was to assess at rest the effects of 30% oxygen inhalation on dyspnea, breathing pattern, neuromuscular inspiratory drive based on measurement of mouth occlusion pressure (P0.1), and dynamic hyperinflation (DH), as reflected by changes in inspiratory capacity (IC).
Ten patients with stable CAO receiving long-term oxygen were studied at rest, before and after 5, 15, and 25 min of oxygen administration. Severity of dyspnea was rated using the visual analog scale (VAS). Breathing pattern parameters, P0.1, IC, and tidal expiratory flow limitation (EFL), were measured sequentially.
Eight patients exhibited EFL under baseline condition. During 30% oxygen breathing, the VAS score significantly decreased, associated with a concurrent increase of IC (11%). There was also a significant reduction of minute ventilation and tidal volume (11% and 12%, respectively), which was due to a significant decrease of mean inspiratory flow. Although not significantly, P0.1 decreased by 13%. Finally, two patients reverted from EFL to no EFL.
Patients with CAO receiving long-term oxygen may benefit from hyperoxic breathing at rest, since it decreases the ventilation and the degree of DH, with concurrent improvement of dyspnea sensation.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>12684291</pmid><doi>10.1378/chest.123.4.1038</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Airway management Biological and medical sciences breathing pattern COPD Diseases of the respiratory system dynamic hyperinflation Dyspnea Dyspnea - etiology Dyspnea - physiopathology Dyspnea - therapy Gas flow Humans Hypoxia - etiology Hypoxia - physiopathology Hypoxia - therapy Inspiratory Capacity Male Medical sciences Middle Aged mouth occlusion pressure oxygen Oxygen Inhalation Therapy Patients Pulmonary arteries Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Respiratory Function Tests Spirometry Treatment Outcome |
| title | Acute Effects of Hyperoxia on Dyspnea in Hypoxemia Patients With Chronic Airway Obstruction at Rest |
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