Regulation of U3 snRNA expression during myoblast differentiation
Differentiation of proliferating rat L6 myoblasts to syncytial multinucleated myotubes results in a significant downshift in the rate of U3 snRNA gene transcription, paralleling the decrease in rRNA synthesis previously documented. Coordinate production of U3 snRNA and rRNA during the differentiatio...
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| Veröffentlicht in: | Experimental cell research 1992-09, Vol.202 (1), p.183-189 |
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| creator | Glibetic, Marija Larson, Dawn E. Sienna, Nancy Bachellerie, Jean-Pierre Sells, Bruce H. |
| description | Differentiation of proliferating rat L6 myoblasts to syncytial multinucleated myotubes results in a significant downshift in the rate of U3 snRNA gene transcription, paralleling the decrease in rRNA synthesis previously documented. Coordinate production of U3 snRNA and rRNA during the differentiation process adds further support for a role of U3 snRNA in ribosome biogenesis. Despite the dramatic decrease in U3 snRNA transcription during differentiation, a corresponding drop in the cellular level of U3 snRNA does not occur. In myotubes, the amount of U3 snRNA is regulated at the post-transcriptional level in which there is a significant accumulation of U3 snRNA in the cytoplasm of myotubes. This intracellular redistribution of U3 snRNA may significantly affect the entire process of rRNA maturation or result from the decrease in ribosome production accompanying terminal differentiation of myoblasts. |
| doi_str_mv | 10.1016/0014-4827(92)90418-8 |
| format | Article |
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Coordinate production of U3 snRNA and rRNA during the differentiation process adds further support for a role of U3 snRNA in ribosome biogenesis. Despite the dramatic decrease in U3 snRNA transcription during differentiation, a corresponding drop in the cellular level of U3 snRNA does not occur. In myotubes, the amount of U3 snRNA is regulated at the post-transcriptional level in which there is a significant accumulation of U3 snRNA in the cytoplasm of myotubes. 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This intracellular redistribution of U3 snRNA may significantly affect the entire process of rRNA maturation or result from the decrease in ribosome production accompanying terminal differentiation of myoblasts.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell Biology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Line</subject><subject>Cell Nucleus - physiology</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. 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Coordinate production of U3 snRNA and rRNA during the differentiation process adds further support for a role of U3 snRNA in ribosome biogenesis. Despite the dramatic decrease in U3 snRNA transcription during differentiation, a corresponding drop in the cellular level of U3 snRNA does not occur. In myotubes, the amount of U3 snRNA is regulated at the post-transcriptional level in which there is a significant accumulation of U3 snRNA in the cytoplasm of myotubes. This intracellular redistribution of U3 snRNA may significantly affect the entire process of rRNA maturation or result from the decrease in ribosome production accompanying terminal differentiation of myoblasts.</abstract><cop>SAN DIEGO</cop><pub>Elsevier Inc</pub><pmid>1380919</pmid><doi>10.1016/0014-4827(92)90418-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blotting, Northern Cell Biology Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell Line Cell Nucleus - physiology Cell physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Kinetics Life Sciences & Biomedicine Molecular and cellular biology Muscles - cytology Muscles - physiology Oncology Plasmids Rats RNA - genetics RNA - isolation & purification RNA Precursors - biosynthesis RNA Precursors - isolation & purification RNA, Small Nuclear - biosynthesis RNA, Small Nuclear - genetics RNA, Small Nuclear - isolation & purification Science & Technology Time Factors Transcription, Genetic |
| title | Regulation of U3 snRNA expression during myoblast differentiation |
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