Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat
To determine the influence of neurons of the ventral hippocampus on dopamine (DA) turnover in other limbic areas, spontaneous and amphetamine-induced locomotion as well as DA and its metabolites were assayed in nucleus accumbens, medial prefrontal cortex and anteromedial striatum, 14 and 28 days aft...
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| Veröffentlicht in: | Brain research 1992-07, Vol.585 (1), p.1-6 |
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| creator | Lipska, Barbara K. Jaskiw, George E. Chrapusta, Stanislaw Karoum, Farouk Weinberger, Daniel R. |
| description | To determine the influence of neurons of the ventral hippocampus on dopamine (DA) turnover in other limbic areas, spontaneous and amphetamine-induced locomotion as well as DA and its metabolites were assayed in nucleus accumbens, medial prefrontal cortex and anteromedial striatum, 14 and 28 days after bilateral ibotenic acid (IA) or sham lesions of the ventral hippocampus in the rat. Spontaneous locomotion was increased 28 days postoperatively, while
d-amphetamine induced locomotion was augmented both 14 and 28 days postoperatively in IA lesioned animals. DA levels in the nucleus accumbens were decreased on the 14th, but increased on the 28th day after the lesion. Dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and the DOPAC/DA ratio in the medial prefrontal cortex (MPFC) were reduced 28 days postoperatively. Moreover, there was a significant negative correlation between the DOPAC/DA ratio in the MPFC and DA levels in the nucleus accumbens at this time point. These data indicate that a lesion of the ventral hippocampus can produce differential changes in cortical and limbic DA activity. Implications for an animal model of schizophrenia are considered. |
| doi_str_mv | 10.1016/0006-8993(92)91184-G |
| format | Article |
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d-amphetamine induced locomotion was augmented both 14 and 28 days postoperatively in IA lesioned animals. DA levels in the nucleus accumbens were decreased on the 14th, but increased on the 28th day after the lesion. Dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and the DOPAC/DA ratio in the medial prefrontal cortex (MPFC) were reduced 28 days postoperatively. Moreover, there was a significant negative correlation between the DOPAC/DA ratio in the MPFC and DA levels in the nucleus accumbens at this time point. These data indicate that a lesion of the ventral hippocampus can produce differential changes in cortical and limbic DA activity. Implications for an animal model of schizophrenia are considered.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(92)91184-G</identifier><identifier>PMID: 1511295</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amphetamine ; Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Dopamine ; Dopamine - metabolism ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - physiology ; Ibotenic Acid ; Locomotion ; Male ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Prefrontal cortex ; Rats ; Rats, Inbred Strains ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1992-07, Vol.585 (1), p.1-6</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-13fc9c8423aa7b5826b8253f214d342ead5f6f16283925142c534afe2c476ff63</citedby><cites>FETCH-LOGICAL-c483t-13fc9c8423aa7b5826b8253f214d342ead5f6f16283925142c534afe2c476ff63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(92)91184-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5442949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1511295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipska, Barbara K.</creatorcontrib><creatorcontrib>Jaskiw, George E.</creatorcontrib><creatorcontrib>Chrapusta, Stanislaw</creatorcontrib><creatorcontrib>Karoum, Farouk</creatorcontrib><creatorcontrib>Weinberger, Daniel R.</creatorcontrib><title>Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>To determine the influence of neurons of the ventral hippocampus on dopamine (DA) turnover in other limbic areas, spontaneous and amphetamine-induced locomotion as well as DA and its metabolites were assayed in nucleus accumbens, medial prefrontal cortex and anteromedial striatum, 14 and 28 days after bilateral ibotenic acid (IA) or sham lesions of the ventral hippocampus in the rat. Spontaneous locomotion was increased 28 days postoperatively, while
d-amphetamine induced locomotion was augmented both 14 and 28 days postoperatively in IA lesioned animals. DA levels in the nucleus accumbens were decreased on the 14th, but increased on the 28th day after the lesion. Dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and the DOPAC/DA ratio in the medial prefrontal cortex (MPFC) were reduced 28 days postoperatively. Moreover, there was a significant negative correlation between the DOPAC/DA ratio in the MPFC and DA levels in the nucleus accumbens at this time point. These data indicate that a lesion of the ventral hippocampus can produce differential changes in cortical and limbic DA activity. Implications for an animal model of schizophrenia are considered.</description><subject>Amphetamine</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - physiology</subject><subject>Ibotenic Acid</subject><subject>Locomotion</subject><subject>Male</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Prefrontal cortex</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFSEQhYnRjNfRN9CEhTG6aO0Cum-zMTGT8TrJJG50TWi6yGBoaIGeOA_juw73x3GnK1J1vjoFHEJeQvseWug_tG3bN4OU_K1k7yTAIJrdI7KBYcuanon2Mdk8IE_Js5x_1JJz2Z6RM-gAmOw25PfVGAsGZ6g2bqIes4uBRkvLDdJbDCVpT2_cskSj52XNdHLWYqqC097fUV0rU2o7Lnp2AakOE3W1MWPRY_SuYKYuHOzCajxWC23MOo8Y8gFeEtoUQ6l7TEwFf_3Bky7PyROrfcYXp_OcfP98-e3iS3P9dXd18em6MWLgpQFujTSDYFzr7dgNrB8H1nHLQExcMNRTZ3sLPRu4ZB0IZjoutEVmxLa3tufn5M3Rd0nx54q5qNllg97rgHHNasuhB7bt_gtCzwGgFRUUR9CkmHN9olqSm3W6U9CqfXxqn43aZ6MkU4f41K6OvTr5r-OM09-hY15Vf33SdTba26SDcfkB64RgUsiKfTxiWD_t1mFS2TgMBieXalxqiu7f97gHTQG46Q</recordid><startdate>19920710</startdate><enddate>19920710</enddate><creator>Lipska, Barbara K.</creator><creator>Jaskiw, George E.</creator><creator>Chrapusta, Stanislaw</creator><creator>Karoum, Farouk</creator><creator>Weinberger, Daniel R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920710</creationdate><title>Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat</title><author>Lipska, Barbara K. ; Jaskiw, George E. ; Chrapusta, Stanislaw ; Karoum, Farouk ; Weinberger, Daniel R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-13fc9c8423aa7b5826b8253f214d342ead5f6f16283925142c534afe2c476ff63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amphetamine</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - physiology</topic><topic>Ibotenic Acid</topic><topic>Locomotion</topic><topic>Male</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Prefrontal cortex</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipska, Barbara K.</creatorcontrib><creatorcontrib>Jaskiw, George E.</creatorcontrib><creatorcontrib>Chrapusta, Stanislaw</creatorcontrib><creatorcontrib>Karoum, Farouk</creatorcontrib><creatorcontrib>Weinberger, Daniel R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipska, Barbara K.</au><au>Jaskiw, George E.</au><au>Chrapusta, Stanislaw</au><au>Karoum, Farouk</au><au>Weinberger, Daniel R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1992-07-10</date><risdate>1992</risdate><volume>585</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>To determine the influence of neurons of the ventral hippocampus on dopamine (DA) turnover in other limbic areas, spontaneous and amphetamine-induced locomotion as well as DA and its metabolites were assayed in nucleus accumbens, medial prefrontal cortex and anteromedial striatum, 14 and 28 days after bilateral ibotenic acid (IA) or sham lesions of the ventral hippocampus in the rat. Spontaneous locomotion was increased 28 days postoperatively, while
d-amphetamine induced locomotion was augmented both 14 and 28 days postoperatively in IA lesioned animals. DA levels in the nucleus accumbens were decreased on the 14th, but increased on the 28th day after the lesion. Dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and the DOPAC/DA ratio in the medial prefrontal cortex (MPFC) were reduced 28 days postoperatively. Moreover, there was a significant negative correlation between the DOPAC/DA ratio in the MPFC and DA levels in the nucleus accumbens at this time point. These data indicate that a lesion of the ventral hippocampus can produce differential changes in cortical and limbic DA activity. Implications for an animal model of schizophrenia are considered.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1511295</pmid><doi>10.1016/0006-8993(92)91184-G</doi><tpages>6</tpages></addata></record> |
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| subjects | Amphetamine Animals Behavior, Animal - physiology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dopamine Dopamine - metabolism Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - physiology Ibotenic Acid Locomotion Male Nucleus accumbens Nucleus Accumbens - metabolism Prefrontal cortex Rats Rats, Inbred Strains Time Factors Vertebrates: nervous system and sense organs |
| title | Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat |
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