Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance

ATP-sensitive potassium (K(ATP)) channels are required for maintenance of homeostasis during the metabolically demanding adaptive response to stress. However, in disease, the effect of cellular remodeling on K(ATP) channel behavior and associated tolerance to metabolic insult is unknown. Here, trans...

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Veröffentlicht in:	The EMBO journal 2003-04, Vol.22 (8), p.1732-1742
Hauptverfasser:	Hodgson, Denice M, Zingman, Leonid V, Kane, Garvan C, Perez-Terzic, Carmen, Bienengraeber, Martin, Ozcan, Cevher, Gumina, Richard J, Pucar, Darko, O'Coclain, Fergus, Mann, Douglas L, Alekseev, Alexey E, Terzic, Andre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Calcium - metabolism Cardiac Output, Low - metabolism Cardiotonic Agents - pharmacology Creatine Kinase - metabolism Dinitrophenols - pharmacology Female Ion Channel Gating Isoproterenol - pharmacology Male Mice Mitochondria - metabolism Myocardium - ultrastructure Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Patch-Clamp Techniques Potassium Channels - metabolism Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism Transgenes Uncoupling Agents - pharmacology Ventricular Remodeling - physiology
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