Enantiomeric separation of β-blockers by HPLC using ( R)-1-naphthylglycine and 3,5-dinitrobenzoic acid as chiral stationary phase

Direct liquid chromatographic separations of the enantiomers of metoprolol and bisoprolol have been developed, using ( R)-1-naphthylglycine and 3,5-dinitrobenzoic acid as chiral stationary phase (CSP). The separations were achieved in a normal phase system employing a mobile phase containing n-hexan...

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