Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

Primitive malignant progenitors defined as nonobese diabetic/severe combined immunodeficient (NOD/SCID) leukemia-initiating cells or NOD/SL-IC from patients with acute myeloid leukemia (AML) can be detected and quantitated in sublethally irradiated NOD/SCID mice. However, there is variability in the...

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Veröffentlicht in:	Leukemia 2003-04, Vol.17 (4), p.760-763
Hauptverfasser:	Feuring-Buske, M, Gerhard, B, Cashman, J, Humphries, R K, Eaves, C J, Hogge, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Animals beta 2-Microglobulin - deficiency beta 2-Microglobulin - genetics Biological and medical sciences Bone marrow Bone Marrow - pathology Cancer Research Cells (biology) Colony-stimulating factor Critical Care Medicine Diabetes mellitus Dilution Flow Cytometry Graft Survival Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - physiology Growth factors Hematologic and hematopoietic diseases Hematology Humans Immunodeficiency In Situ Hybridization, Fluorescence Intensive Interleukin 3 Interleukin-3 - genetics Interleukin-3 - physiology Internal Medicine Intravenous administration Leukemia Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes (granulocytic) Macrophages Medical innovations Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, Knockout Mice, SCID Mice, Transgenic Neoplasm Transplantation Oncology original-manuscript Progenitor cells Radiation Chimera Recombinant Fusion Proteins - physiology Stem Cell Factor - genetics Stem Cell Factor - physiology Stem cells Transgenic mice Transplantation Transplantation, Heterologous
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