Expression of multidrug resistance protein 4 and 5 in the porcine coronary and pulmonary arteries

Guanosine 3′,5′-cyclic monophosphate (cGMP) has an important role in regulating vascular smooth muscle tone. We examined whether mRNA for multidrug resistance protein (MRP) 4 and MRP5, which were recently identified as ATP-dependent export pumps for cyclic nucleotides, is expressed in the porcine co...

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Veröffentlicht in:	European journal of pharmacology 2003-04, Vol.466 (1), p.223-224
Hauptverfasser:	Mitani, Akiko, Nakahara, Tsutomu, Sakamoto, Kenji, Ishii, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport cGMP Coronary Vessels - metabolism Cyclic GMP - metabolism Drug Resistance, Multiple Gene Expression Medical sciences Multidrug resistance protein Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - genetics Muscle, Smooth, Vascular - metabolism Pulmonary Artery - metabolism RNA, Messenger - biosynthesis Swine Vascular vessel
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Zusammenfassung:	Guanosine 3′,5′-cyclic monophosphate (cGMP) has an important role in regulating vascular smooth muscle tone. We examined whether mRNA for multidrug resistance protein (MRP) 4 and MRP5, which were recently identified as ATP-dependent export pumps for cyclic nucleotides, is expressed in the porcine coronary and pulmonary arteries. The results showed that both arteries express mRNA for MRP4 and MRP5, and thus these proteins may be novel targets for the prevention and/or treatment of various cardiovascular diseases.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(03)01552-8